Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Prem Khanal"'
Autor:
Natalie M. Deschenes, Camilyn Cheng, Prem Khanal, Brianna M. Quinville, Alex E. Ryckman, Melissa Mitchell, Alexey V. Pshezhetsky, Jagdeep S. Walia
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
AB-Variant GM2 gangliosidosis (ABGM2) is a rare and lethal genetic disorder caused by mutations in the GM2A gene that lead to fatal accumulation of GM2 gangliosides (GM2) in neurons of the central nervous system (CNS). GM2A encodes a transport protei
Externí odkaz:
https://doaj.org/article/5df49225961e460484ba2d40058f1c55
Autor:
Natalie M. Deschenes, Camilyn Cheng, Alex E. Ryckman, Brianna M. Quinville, Prem Khanal, Melissa Mitchell, Zhilin Chen, Waheed Sangrar, Steven J. Gray, Jagdeep S. Walia
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9217 (2023)
GM2 gangliosidosis is a group of genetic disorders that result in the accumulation of GM2 ganglioside (GM2) in brain cells, leading to progressive central nervous system (CNS) atrophy and premature death in patients. AB-variant GM2 gangliosidosis (AB
Externí odkaz:
https://doaj.org/article/1911627c039c442b94dded2fff3ded7d
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Hippo signalling pathway is an emerging signalling pathway that plays important roles in organ size control, tumorigenesis, metastasis, stress response, apoptosis, stem cell differentiation and renewal during development and tissue homeostas
Externí odkaz:
https://doaj.org/article/937f5fb63a0a43d4a7328c608d924507
Autor:
Yulei Zhao, Kathrin Tyrishkin, Calvin Sjaarda, Prem Khanal, Jeff Stafford, Michael Rauh, Xudong Liu, Tomas Babak, Xiaolong Yang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/0926e2b2fa3a44f58bbee6298b030d9b
The Hippo pathway is a signaling cascade that plays important roles in organ size control, tumorigenesis, metastasis, stress response, stem cell differentiation, and renewal during development and tissue homeostasis and mechanotransduction. Recently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66aacbe8089c037680672fc67300c8a1
https://doi.org/10.1158/1541-7786.c.6540258.v1
https://doi.org/10.1158/1541-7786.c.6540258.v1
Supplementary Figure 1. Expression of LATS1 after anti-tubulin treatments. Supplementary Figure 2. Phosphorylation of LATS2 after anti-tubulin treatments in various cell lines. Supplementary Figure 3. Phosphorylation of LATS1 by Cdk1/Cyclin B in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054317c47570a223656e6bcdcad2ec8d
https://doi.org/10.1158/1541-7786.22512495.v1
https://doi.org/10.1158/1541-7786.22512495.v1
Supplementary Table 1. Cellular proteins with enhanced interaction with LATS2 after TX and NOC treatments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ef33c36af8e0cf9fee005bc062a6d6
https://doi.org/10.1158/1541-7786.22512492
https://doi.org/10.1158/1541-7786.22512492
Autor:
Xiaolong Yang, Michael J. Rauh, Charles H. Graham, Lori M. Minassian, Prem Khanal, Brooke Snetsinger, Yawei Hao, Min Ling, Taha Azad, Helena J. Janse van Rensburg
The Hippo pathway component WW domain-containing transcription regulator 1 (TAZ) is a transcriptional coactivator and an oncogene in breast and lung cancer. Transcriptional targets of TAZ that modulate immune cell function in the tumor microenvironme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::958413dca1c1a7d5f13b09249c443578
https://doi.org/10.1158/0008-5472.c.6510825.v1
https://doi.org/10.1158/0008-5472.c.6510825.v1
Autor:
Xiaolong Yang, Michael J. Rauh, Charles H. Graham, Lori M. Minassian, Prem Khanal, Brooke Snetsinger, Yawei Hao, Min Ling, Taha Azad, Helena J. Janse van Rensburg
This file contains supplementary figures summarizing control experiments that support conclusions from the main text. Figure S1: Candidates from our NanoString screen are not upregulated due to EMT or doxycycline treatment. Figure S2: CYR61 mRNA expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88385611fb5bf11279d3262f798d91c
https://doi.org/10.1158/0008-5472.22421070
https://doi.org/10.1158/0008-5472.22421070
PDF file - 547KB, Response of MCF10A cells expressing wild-type and mutant YAP to Cisplatin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5821409e733175292f0f0f7a02c6d5e5
https://doi.org/10.1158/0008-5472.22402218.v1
https://doi.org/10.1158/0008-5472.22402218.v1