Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Prekupec, Svjetlana"'
Autor:
Prekupec, Svjetlana, Makuc, Damjan, Plavec, Janez, Šuman, Lidija, Kralj, Marijeta, Pavelić, Krešimir, Balzarini, Jan, De Clercq, Erik, Mintas, Mladen, Raić-Malić, Silvana
The synthetic route for introduction of a fluoroalkyl (7-12, 14), fluoroalkenyl (16 and 17), fluorophenylalkyl (18, 20, 21 and 23) and fluorophenylalkenyl (19, 22) side chain at C-6 of the pyrimidine involved the lithiation of the pyrimidine derivati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::1647f85616aa3581fd8dc69c798d82ad
https://www.bib.irb.hr/326202
https://www.bib.irb.hr/326202
Autor:
Prekupec, Svjetlana, Makuc, Damjan, Krištafor, Vedran, Cetina, Mario, Lesjak, Danijela, Plavec, Janez, Kralj, Marijeta, Pavelić, Krešimir, Balzarini, Jan, De Clercq, Erik, Mintas, Mladen, Raić-Malić, Silvana
Pyrimidine derivatives and their nucleosides have great biological significance because they exhibit a wide range of antiviral and anticancer activities. The pronounced biological activities exhibited by this class of compounds led us to synthesize t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::8e96555badd3aab51f313b46f5339bf1
https://www.bib.irb.hr/292038
https://www.bib.irb.hr/292038
Autor:
Prekupec, Svjetlana, Makuc, Damjan, Krištafor, Vedran, Cetina, Mario, Lesjak, Danijela, Plavec, Janez, Mintas, Mladen, Raić-Malić, Silvana
Pyrimidine derivatives and their nucleosides have great biological significance because they exhibit a wide range of antiviral and anticancer activities. Some uracil and pyrimidinone derivatives substituted at C-5 or C-6 position have emerged in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::58d61545fdfcb507c2dceae69b809b0f
https://www.bib.irb.hr/258278
https://www.bib.irb.hr/258278
Autor:
Prekupec, Svjetlana, Filipović, Ivana, Makuc, Damjan, Plavec, Janez, Kraljević, Sandra, Kralj, Marijeta, Pavelić, Krešimir, Balzarini, Jan, De Clercq, Erik, Raić-Malić, Silvana, Mintas, Mladen
New types of C-6 alkylated pyrimidine derivatives were prepared via lithiation of 2, 4-dimethoxy-5, 6-dimethyl pyrimidine and 2, 4-dimethoxy-6-methyl pyrimidine and subsequent nucleophilic addition or substitution reactions of the organolithium inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::ca2aa31446b94b40ef6141f39f566243
https://www.bib.irb.hr/192748
https://www.bib.irb.hr/192748
Autor:
Prekupec, Svjetlana, Plavec, Janez, Cetina, Mario, Kraljević, Sandra, Kralj, Marijeta, Pavelić, Krešimir, Balzarini, Jan, De Clercq, Erik, Raić-Malić, Silvana, Mintas, Mladen
New types of C-6 alkylated pyrimidine derivatives 3-7 were prepared via lithiation of 2, 4-dimethoxy-5, 6-dimethyl pyrimidine and subsequent nucleophilic addition or substitution reactions of the organolithium intermediate with acetaldehyde, fluoroac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::75f24c5cb5ae087e7c31e4dc41970b9a
https://www.bib.irb.hr/153872
https://www.bib.irb.hr/153872
Autor:
Gazivoda, Tatjana, Prekupec, Svjetlana, Nagl, Ante, Cetina, Mario, Balzarini, Jan, De Clercq, Erik, Mintas, Mladen, Raić-Malić, Silvana
The pyrimidine derivatives of 2, 3-O, O-dibenzyl-4, 5-didehydro-5, 6-dideoxy-L-ascorbic acid (A) and 2, 3-O, O-dibenzyl-6-deoxy-L-ascorbic acid (B) were synthesized by Vorbrüggen condensation of uracil and its 5-substituted derivatives with 5, 6-O,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::788da22e188a73e4d404b7e4e1dc437d
https://www.bib.irb.hr/86315
https://www.bib.irb.hr/86315
Synthesis And Biological Evaluation Of Fluorinated And Iodinated Purine Acyclic Nucleoside Analogues
Autor:
Prekupec, Svjetlana, Gazivoda, Tatjana, Raić-Malić, Silvana, Balzarini, Jan, De Clercq, Erik, Mintas, Mladen
Gene therapy (suicide gene therapy) is a method which uses herpes simplex virus thymidine kinase (HSV-1 TK) and prodrug (ganciclovir-GCV) combination for the treatment of cancer. That approach has been succesfully applied for the treatment of bone ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5596bb06663279784e77a6b589e5dfc9
https://www.bib.irb.hr/86302
https://www.bib.irb.hr/86302
Autor:
Gazivoda, Tatjana, Prekupec, Svjetlana, Balzarini, Jan, De Clercq, Erik, Mintas, Mladen and Raic-Malic, Silvana
Pyrimidine derivatives of 2,3-O,O-dibenzyl-4,5-didehydro-5,6-dideoxy-L-ascorbic acid (A) and 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid (B) were synthesized by condensation of uracil and its 5-substituted derivatives with 5,6-O,O-diacetyl-2,3-O,O-diben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::136f1b269336856c0b76ed0ce521ccd7
https://www.bib.irb.hr/86046
https://www.bib.irb.hr/86046
Autor:
Prekupec, Svjetlana, Gazivoda, Tatjana, Svedružić, Draženka, Raić-Malić, Silvana, Balzarini, Jan, De Clercq, Erik, Mintas, Mladen
Genska terapija (suicidna terapija genima) je metoda koja rabi kombinaciju enzima (timidin kinaza virusa herpes simplex tipa 1 - HSV1-TK) i prolijeka (ganciklovir - GCV) za liječenje raka. Ta se metoda uspješno koristi za liječenje zloćudnih otek
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b508125270ac80a02cf4c9a41d3a2e20
https://www.bib.irb.hr/85940
https://www.bib.irb.hr/85940
Autor:
Prekupec, Svjetlana
Virusne su infekcije problem svjetskih razmjera koji još nije riješen. One danas obuhvaćaju oko 60 posto svih oboljenja u razvijenim zemljama i zemljama u razvoju. Predstavnici porodice virusa herpesa uzrok su oboljenja kod 60-95 posto svjetske po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::1a31856c66090c6d9dce2e1395d690ce
https://www.bib.irb.hr/43825
https://www.bib.irb.hr/43825