Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Preiss–Handler pathway"'
Autor:
Nils W. F. Meijer, Johan Gerrits, Susan Zwakenberg, Fried J. T. Zwartkruis, Nanda M. Verhoeven-Duif, Judith J. M. Jans
Publikováno v:
Metabolites, Vol 13, Iss 12, p 1196 (2023)
NAD synthetase 1 (encoded by the gene NADSYN1) is a cytosolic enzyme that catalyzes the final step in the biosynthesis of nicotinamide adenine dinucleotide (NAD+) from tryptophan and nicotinic acid. NADSYN1 deficiency has recently been added to the s
Externí odkaz:
https://doaj.org/article/9e00fe961e6c47efa16164d992d87e11
Autor:
Xinhui Liu, Denggui Luo, Shiying Huang, Siqi Liu, Bing Zhang, Fochang Wang, Jiandong Lu, Jianping Chen, Shunmin Li
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Chronic kidney disease (CKD) is a global public health problem with high morbidity and mortality. Decreased nicotinamide adenine dinucleotide (NAD+) levels were found to be associated with aging, cancer, and neurodegenerative and metabolic disorders.
Externí odkaz:
https://doaj.org/article/f01c0119db7843d0b590dd9ca402a78f
Autor:
Jorge Franco, Francesco Piacente, Melanie Walter, Simone Fratta, Moustafa Ghanem, Andrea Benzi, Irene Caffa, Alexander V. Kurkin, Andrea Altieri, Patrick Herr, Macarena Martínez-Bailén, Inmaculada Robina, Santina Bruzzone, Alessio Nencioni, Alberto Del Rio
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 855 (2022)
NAPRT, the rate-limiting enzyme of the Preiss–Handler NAD biosynthetic pathway, has emerged as a key biomarker for the clinical success of NAMPT inhibitors in cancer treatment. Previous studies found that high protein levels of NAPRT conferred resi
Externí odkaz:
https://doaj.org/article/3955bfbf6c32440698b24b3e27358897
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Frontiers in Plant Science, Vol 10 (2020)
Externí odkaz:
https://doaj.org/article/49705b5233f541f3a0cd5dfe9a051e31
Publikováno v:
Frontiers in Plant Science, Vol 10 (2019)
The Preiss-Handler pathway, which salvages nicotinate (NA) for NAD synthesis, is a conserved biochemical pathway in land plants. We previously demonstrated that various NA conjugations (mainly methylation and glycosylation) shared the NA detoxificati
Externí odkaz:
https://doaj.org/article/735b747b599b413398d66df60bed9592
Autor:
Ada Serena Marletta, Alberto Massarotti, Giuseppe Orsomando, Giulio Magni, Menico Rizzi, Silvia Garavaglia
Publikováno v:
FEBS Open Bio, Vol 5, Iss 1, Pp 419-428 (2015)
Nicotinic acid phosphoribosyltransferase (EC 2.4.2.11) (NaPRTase) is the rate‐limiting enzyme in the three‐step Preiss–Handler pathway for the biosynthesis of NAD. The enzyme catalyzes the conversion of nicotinic acid (Na) and 5‐phosphoribosy
Externí odkaz:
https://doaj.org/article/22745da4fbb14ee191d1014ab8277f75
Autor:
Franco, Jorge, Piacente, Francesco, Walter, Melanie, Fratta, Simone, Ghanem, Moustafa, Benzi, Andrea, Martínez Bailén, Macarena, Robina Ramírez, Inmaculada, Del Río, Alberto
NAPRT, the rate-limiting enzyme of the Preiss–Handler NAD biosynthetic pathway, has emerged as a key biomarker for the clinical success of NAMPT inhibitors in cancer treatment. Previous studies found that high protein levels of NAPRT conferred resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3272::7a531b1aa2ccc8a6e5c4d3751090879e
Autor:
Denggui Luo, Siqi Liu, Xinhui Liu, Fochang Wang, Shunmin Li, Jiandong Lu, Bing Zhang, Shiying Huang, Jianping Chen
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology
Frontiers in Physiology
Chronic kidney disease (CKD) is a global public health problem with high morbidity and mortality. Decreased nicotinamide adenine dinucleotide (NAD+) levels were found to be associated with aging, cancer, and neurodegenerative and metabolic disorders.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afbfabe65fbef4f8bd7c31660152e832
https://www.frontiersin.org/articles/10.3389/fphys.2021.723690/full
https://www.frontiersin.org/articles/10.3389/fphys.2021.723690/full
Publikováno v:
Nutrients, Vol 13, Iss 1665, p 1665 (2021)
Nutrients
Nutrients
Nicotinamide adenine dinucleotide (NAD) is an essential redox cofactor, but it also acts as a substrate for NAD-consuming enzymes, regulating cellular events such as DNA repair and gene expression. Since such processes are fundamental to support canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3574f29cca9cd81380bd32086b35b924
https://www.mdpi.com/2072-6643/13/5/1665
https://www.mdpi.com/2072-6643/13/5/1665