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Structural Simplification of Bedaquiline: the Discovery of 3-(4-(N,N-dimethylaminomethyl)phenyl)quinoline Derived Antitubercular Lead Compounds

Autor: He, CH, Preiss, LP, Wang, BW, Fu, LF, Wen, HW, Zhang, XZ, Cui, HC, Meier, TK, Yin, DY

Bedaquiline (BDQ) is a novel and highly potent last-line antituberculosis drug that was approved by the US FDA in 2013. Owing to its stereo-structural complexity, chemical synthesis and compound optimization are rather difficult and expensive. This s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::a0696154ad40554bee337adc206b93bc
http://hdl.handle.net/10044/1/41516

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