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Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects.

Autor: Michael Callahan, Anthony M Treston, Grace Lin, Marla Smith, Brian Kaufman, Mansoora Khaliq, Lisa Evans DeWald, Kevin Spurgers, Kelly L Warfield, Preeya Lowe, Matthew Duchars, Aruna Sampath, Urban Ramstedt

Publikováno v: PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010636 (2022)

BackgroundUV-4 (N-(9'-methoxynonyl)-1-deoxynojirimycin, also called MON-DNJ) is an iminosugar small-molecule oral drug candidate with in vitro antiviral activity against diverse viruses including dengue, influenza, and filoviruses and demonstrated in

Externí odkaz: https://doaj.org/article/1b9a38644e1447e182ac97752d59a1a1

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Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects

Autor: Michael Callahan, Anthony M. Treston, Grace Lin, Marla Smith, Brian Kaufman, Mansoora Khaliq, Lisa Evans DeWald, Kevin Spurgers, Kelly L. Warfield, Preeya Lowe, Matthew Duchars, Aruna Sampath, Urban Ramstedt

Publikováno v: PLoS neglected tropical diseases. 16(8)

Background UV-4 (N-(9’-methoxynonyl)-1-deoxynojirimycin, also called MON-DNJ) is an iminosugar small-molecule oral drug candidate with in vitro antiviral activity against diverse viruses including dengue, influenza, and filoviruses and demonstrated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0873e9b2bf0101cdb41da839ce6559f0
https://pubmed.ncbi.nlm.nih.gov/35939501

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