Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Preeti Manandhar"'
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 1, Pp n/a-n/a (2022)
Abstract Tapentadol is a centrally acting analgesic with a dual mechanism of action. It acts as an agonist at the µ receptor and inhibitor of noradrenaline reuptake. Clinical trials suggest similar analgesic efficacy of tapentadol, oxycodone, and mo
Externí odkaz:
https://doaj.org/article/35b8696666504e849b71807823a7b964
Publikováno v:
PeerJ, Vol 9, p e11175 (2021)
Background Pregabalin and gabapentin improve neuropathic pain symptoms but there are emerging concerns regarding their misuse. This is more pronounced among patients with substance use disorder, particularly involving opioids. Co-ingestion of gabapen
Externí odkaz:
https://doaj.org/article/c6ab265b5a974d7da99138456cfdc25c
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 1, Pp n/a-n/a (2022)
Tapentadol is a centrally acting analgesic with a dual mechanism of action. It acts as an agonist at the µ receptor and inhibitor of noradrenaline reuptake. Clinical trials suggest similar analgesic efficacy of tapentadol, oxycodone, and morphine in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4181ecdd61e73614ce77109c8711787d
https://pubmed.ncbi.nlm.nih.gov/35084120
https://pubmed.ncbi.nlm.nih.gov/35084120
Publikováno v:
Methods in Molecular Biology ISBN: 9781071608838
Quantitative measurement of receptor signaling by different ligands is important for understanding the mechanism of drug action and screening of drugs. Here, we describe a simple and cost-effective method of measuring adenylyl cyclase inhibition, one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41bd67ed8b941264abff5aad7ccdcbd5
https://doi.org/10.1007/978-1-0716-0884-5_11
https://doi.org/10.1007/978-1-0716-0884-5_11
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2201
Quantitative measurement of receptor signaling by different ligands is important for understanding the mechanism of drug action and screening of drugs. Here, we describe a simple and cost-effective method of measuring adenylyl cyclase inhibition, one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0a9dab635dbfbafed666abd485955af0
https://pubmed.ncbi.nlm.nih.gov/32975794
https://pubmed.ncbi.nlm.nih.gov/32975794
Autor:
Michelle L. Halls, Julie Sanchez, Claudia Alamein, Meritxell Canals, Alexander Gillis, Frank Schmiedel, J. Robert Lane, Tristan A. Reekie, Preeti Manandhar, Michael Kassiou, Mark Connor, Andrea Kliewer, MacDonald J. Christie, Arisbel B. Gondin, Timothy A. Katte, Marina Santiago, Cornelius Krasel, Herman D. Lim, Stefan Schulz, Natasha L. Grimsey, Barrie Kellam, Sebastian Fritzwanker
Publikováno v:
Science signaling. 13(625)
Biased agonism at G protein–coupled receptors describes the phenomenon whereby some drugs can activate some downstream signaling activities to the relative exclusion of others. Descriptions of biased agonism focusing on the differential engagement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9a0b0ae30a514d390609b92d3b0fab
https://pubmed.ncbi.nlm.nih.gov/32234959
https://pubmed.ncbi.nlm.nih.gov/32234959