Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Preeti Bharaj"'
Autor:
Yazmin B. Martinez-Martinez, Matthew B. Huante, Sadhana Chauhan, Kubra F. Naqvi, Preeti Bharaj, Janice J. Endsley
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-15 (2023)
Abstract Therapeutic vaccines have promise as adjunctive treatment for tuberculosis (TB) or as preventives against TB relapse. An important development challenge is the limited understanding of T helper (Th) cell roles during these stages of disease.
Externí odkaz:
https://doaj.org/article/ff8ab6f613584aa48601eb8daf6a6c81
Autor:
Philipp A. Ilinykh, Sivakumar Periasamy, Kai Huang, Natalia A. Kuzmina, Palaniappan Ramanathan, Michelle N. Meyer, Chad E. Mire, Ivan V. Kuzmin, Preeti Bharaj, Jessica R. Endsley, Maria Chikina, Stuart C. Sealfon, Steven G. Widen, Mark A. Endsley, Alexander Bukreyev
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-16 (2022)
Abstract Respiratory tract vaccination has an advantage of needle-free delivery and induction of mucosal immune response in the portal of SARS-CoV-2 entry. We utilized human parainfluenza virus type 3 vector to generate constructs expressing the full
Externí odkaz:
https://doaj.org/article/f7f896e4aff94be8a7c13063d10aa8bd
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-13 (2021)
Abstract Melioidosis, caused by Burkholderia pseudomallei (Bpm), lacks a vaccine. We identify the immune correlates of protection induced by B. mallei ΔtonB Δhcp1 (CLH001) and Bpm ΔtonB Δhcp1 (PBK001) vaccines against inhalational melioidosis. Mu
Externí odkaz:
https://doaj.org/article/1ed07a95843f4f11b748cd921ed20a08
Autor:
Sarah van Tol, Birte Kalveram, Philipp A Ilinykh, Adam Ronk, Kai Huang, Leopoldo Aguilera-Aguirre, Preeti Bharaj, Adam Hage, Colm Atkins, Maria I Giraldo, Maki Wakamiya, Maria Gonzalez-Orozco, Abbey N Warren, Alexander Bukreyev, Alexander N Freiberg, Ricardo Rajsbaum
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010532 (2022)
Ebola virus (EBOV) VP35 is a polyfunctional protein involved in viral genome packaging, viral polymerase function, and host immune antagonism. The mechanisms regulating VP35's engagement in different functions are not well-understood. We previously s
Externí odkaz:
https://doaj.org/article/7f5b774b9b474e8c892f3effa42555aa
Autor:
Adam Hage, Preeti Bharaj, Sarah van Tol, Maria I. Giraldo, Maria Gonzalez-Orozco, Karl M. Valerdi, Abbey N. Warren, Leopoldo Aguilera-Aguirre, Xuping Xie, Steven G. Widen, Hong M. Moulton, Benhur Lee, Jeffrey R. Johnson, Nevan J. Krogan, Adolfo García-Sastre, Pei-Yong Shi, Alexander N. Freiberg, Ricardo Rajsbaum
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110434- (2022)
Summary: Type I interferons (IFN-I) are essential to establish antiviral innate immunity. Unanchored (or free) polyubiquitin (poly-Ub) has been shown to regulate IFN-I responses. However, few unanchored poly-Ub interactors are known. To identify fact
Externí odkaz:
https://doaj.org/article/1021a0c2a2e14ca9810fefd46e1864bc
Autor:
Nittaya Khakhum, Preeti Bharaj, Julia N Myers, Daniel Tapia, David H Walker, Janice J Endsley, Alfredo G Torres
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 7, p e0007578 (2019)
BackgroundGlanders caused by Burkholderia mallei is a re-emerging zoonotic disease affecting solipeds and humans. Furthermore, B. mallei is genetically related to B. pseudomallei, which is the causative agent of melioidosis. Both facultative intracel
Externí odkaz:
https://doaj.org/article/fc16e6fd886b4f1283e091e697ab27ef
Autor:
Nittaya Khakhum, Preeti Bharaj, Julia N. Myers, Daniel Tapia, Paul B. Kilgore, Brittany N. Ross, David H. Walker, Janice J. Endsley, Alfredo G. Torres
Publikováno v:
mSphere, Vol 4, Iss 1 (2019)
ABSTRACT Burkholderia pseudomallei is a Gram-negative facultative intracellular bacterium and the causative agent of melioidosis, a severe infectious disease found throughout the tropics. This organism is closely related to Burkholderia mallei, the e
Externí odkaz:
https://doaj.org/article/ffbabe08d10f44ba8ffc6eb1a9e89b73
Autor:
Preeti Bharaj, Chunting Ye, Sean Petersen, Qianghu Wang, Baoli Hu, N. Manjunath, Premlata Shankar, Guohua Yi
Publikováno v:
Heliyon, Vol 4, Iss 2 (2018)
We have previously reported that overexpression of Programmed Death -1 Homolog (PD-1H) in human monocytes leads to activation and spontaneous secretion of multiple pro inflammatory cytokines. Here we evaluate changes in monocytes gene expression afte
Externí odkaz:
https://doaj.org/article/03f335cea7e54d869a3f87f684b8ba07
Autor:
Daniel Stadlbauer, Hua Wei Chen, Peifang Sun, Ernesto Santa Ana, Russell P. Tracy, Stuart C. Sealfon, Sagie Mofsowitz, Dawn L. Weir, Megan A. Schilling, Venugopalan D. Nair, Florian Krammer, Jan Marayag, William D. Graham, Yongchao Ge, Rhonda A. Lizewski, Daniel Ewing, Edgar Nunez, Mary Catherine George, Alexander Bukreyev, Andrew G. Letizia, Preeti Bharaj, Natalia Kuzmina, Nada Marjanovic, Chad K. Porter, Franca R. Jones, Sindhu Vangeti, Alessandra Soares-Schanoski, Clare M. Miller, Irene Ramos, Michael Termini, Carl Goforth, Corey A. Balinsky, Danielle M. Parent, Stephen E. Lizewski, Victor A. Sugiharto
Publikováno v:
The Lancet. Respiratory Medicine
Background Whether young adults who are infected with SARS-CoV-2 are at risk of subsequent infection is uncertain. We investigated the risk of subsequent SARS-CoV-2 infection among young adults seropositive for a previous infection. Methods This anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea99e8cf60dbfd1928512a580651679a
https://doi.org/10.1016/s2213-2600(21)00158-2
https://doi.org/10.1016/s2213-2600(21)00158-2
Autor:
Preeti Bharaj, Yao E Wang, Brian E Dawes, Tatyana E Yun, Arnold Park, Benjamin Yen, Christopher F Basler, Alexander N Freiberg, Benhur Lee, Ricardo Rajsbaum
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005880 (2016)
For efficient replication, viruses have developed mechanisms to evade innate immune responses, including the antiviral type-I interferon (IFN-I) system. Nipah virus (NiV), a highly pathogenic member of the Paramyxoviridae family (genus Henipavirus),
Externí odkaz:
https://doaj.org/article/ba0da777b7ea4d80b4ea6b3307a3d2e3