Výsledky vyhledávání - "Preet S. Chadha"

Akademický článek

Diet-induced obesity impairs endothelium-derived hyperpolarization via altered potassium channel signaling mechanisms.

Autor: Rebecca E Haddock, T Hilton Grayson, Margaret J Morris, Lauren Howitt, Preet S Chadha, Shaun L Sandow

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e16423 (2011)

BACKGROUND: The vascular endothelium plays a critical role in the control of blood flow. Altered endothelium-mediated vasodilator and vasoconstrictor mechanisms underlie key aspects of cardiovascular disease, including those in obesity. Whilst the me

Externí odkaz: https://doaj.org/article/a9d638c1b4b046f484809cf1f8d73354

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Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation

Publikováno v: Stanley, C P, Maghzal, G J, Ayer, A, Talib, J, Giltrap, A M, Shengule, S, Wolhuter, K, Wang, Y, Chadha, P, Suarna, C, Prysyazhna, O, Scotcher, J, Dunn, L L, Prado, F M, Nguyen, N, Odiba, J O, Baell, J B, Stasch, J P, Yamamoto, Y, Di Mascio, P, Eaton, P, Payne, R J & Stocker, R 2019, ' Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation ', Nature, vol. 566, no. 7745, pp. 548-552 . https://doi.org/10.1038/s41586-019-0947-3
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Singlet molecular oxygen ( 1 O 2 ) has well-established roles in photosynthetic plants, bacteria and fungi 1–3 , but not in mammals. Chemically generated 1 O 2 oxidizes the amino acid tryptophan to precursors of a key metabolite called N-formylkynu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e9b33be3bb7ffa4340248ba2f051f8
https://pubmed.ncbi.nlm.nih.gov/30809049

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Effective contractile response to voltage-gated Na+ channels revealed by a channel activator

Autor: Alison J. Davis, Iain A. Greenwood, Preet S. Chadha, W.-S. Vanessa Ho

Publikováno v: American Journal of Physiology-Cell Physiology. 304:C739-C747

This study investigated the molecular identity and impact of enhancing voltage-gated Na+ (NaV) channels in the control of vascular tone. In rat isolated mesenteric and femoral arteries mounted for isometric tension recording, the vascular actions of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a8916ad6aec3cdd250b475b000587f
https://doi.org/10.1152/ajpcell.00164.2012

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Potent vasorelaxant activity of the TMEM16A inhibitor T16Ainh-A01

Autor: Iain A. Greenwood, Preet S. Chadha, Anthony P. Albert, Harry A. T. Pritchard, Georgios Vasilikostas, Alison J. Davis, Zhen Yao, Normand Leblanc, Alan S. Verkman, Jian Shi

Publikováno v: British Journal of Pharmacology. 168:773-784

Background and purpose T16A(inh) -A01 is a recently identified inhibitor of the calcium-activated chloride channel TMEM16A. The aim of this study was to test the efficacy of T16A(inh) -A01 for inhibition of calcium-activated chloride channels in vasc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d59985ccdbd1a04a0d0744d3120b70ca
https://doi.org/10.1111/j.1476-5381.2012.02199.x

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Increased caveolae density and caveolin-1 expression accompany impaired NO-mediated vasorelaxation in diet-induced obesity

Autor: Paul P. Bertrand, Margaret J. Morris, Timothy V. Murphy, Sevvandi Senadheera, Preet S. Chadha, T. Hilton Grayson, Shaun L. Sandow, Hui Chen

Publikováno v: Histochemistry and Cell Biology. 139:309-321

Diet-induced obesity induces changes in mechanisms that are essential for the regulation of normal artery function, and in particular the function of the vascular endothelium. Using a rodent model that reflects the characteristics of human dietary ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9ee45200a073dfaf83cc28adc9ad30
https://doi.org/10.1007/s00418-012-1032-2

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Pharmacological dissection of Kv7.1 channels in systemic and pulmonary arteries

Autor: Thomas A. Jepps, Friederike Zunke, Alison J. Davis, Joannes Theodorus Maria Linders, Michael Schwake, Rob Towart, Iain A. Greenwood, Preet S. Chadha

Publikováno v: British Journal of Pharmacology. 166:1377-1387

BACKGROUND AND PURPOSE The aim of this study was to characterize the functional impact of KCNQ1-encoded voltage-dependent potassium channels (Kv7.1) in the vasculature. EXPERIMENTAL APPROACH Mesenteric arteries, intrapulmonary arteries and thoracic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1961653deb281ad9b558146c96372dc6
https://doi.org/10.1111/j.1476-5381.2012.01863.x

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Reduced KCNQ4-Encoded Voltage-Dependent Potassium Channel Activity Underlies Impaired β-Adrenoceptor–Mediated Relaxation of Renal Arteries in Hypertension

Autor: William C. Cole, James D. Moffatt, Friederike Zunke, Iain A. Greenwood, Søren Peter Olesen, Preet S. Chadha, Alison J. Davis, Thomas A. Jepps, Hai-Lei Zhu

Publikováno v: Hypertension. 59:877-884

KCNQ4-encoded voltage-dependent potassium (Kv7.4) channels are important regulators of vascular tone that are severely compromised in models of hypertension. However, there is no information as to the role of these channels in responses to endogenous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0019c43a2833ed85bcd726ed0c9f251e
https://doi.org/10.1161/hypertensionaha.111.187427

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Endothelium-Dependent Vasodilation in Human Mesenteric Artery Is Primarily Mediated by Myoendothelial Gap Junctions Intermediate Conductance Calcium-Activated K+ Channel and Nitric Oxide

Autor: Preet S. Chadha, Shaun L. Sandow, Timothy V. Murphy, Rebecca L. Bertrand, Lauren Howitt, T. Hilton Grayson, Lu Liu, Sevvandi Senadheera, Matt Rikard-Bell

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 336:701-708

Myoendothelial microdomain signaling via localized calcium-activated potassium channel (K(Ca)) and gap junction connexins (Cx) is critical for endothelium-dependent vasodilation in rat mesenteric artery. The present study determines the relative cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc23f565d1fa2a601e93fcbcfe416301
https://doi.org/10.1124/jpet.110.165795

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WHAT'S WHERE AND WHY AT A VASCULAR MYOENDOTHELIAL MICRODOMAIN SIGNALLING COMPLEX

Autor: Shaun L. Sandow, Caryl E. Hill, Donald G. Welsh, Paul M Kerr, Rebecca E. Haddock, Preet S. Chadha, Frances Plane

Publikováno v: Clinical and Experimental Pharmacology and Physiology. 36:67-76

SUMMARY 1 Modulation of vascular cell calcium is critical for the control of vascular tone, blood flow and pressure. 2 Specialized microdomain signalling sites associated with calcium modulation are present in vascular smooth muscle cells, where spat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61713952cf3fd40ef9e2e644b394be5d
https://doi.org/10.1111/j.1440-1681.2008.05076.x

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Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related peptide-induced cerebral reactivity

Autor: Jennifer B. Stott, Georgina Carr, Hei-Lei Zhu, Thomas A. Jepps, William C. Cole, Iain A. Greenwood, Preet S. Chadha

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology. 34(4)

Objective— Middle cerebral artery (MCA) diameter is regulated by inherent myogenic activity and the effect of potent vasodilators such as calcitonin gene-related peptide (CGRP). Previous studies showed that MCAs express KCNQ1, 4, and 5 potassium ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afb043a7d72e2c919139f952e725574
https://pubmed.ncbi.nlm.nih.gov/24558103

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