Výsledky vyhledávání - "Preet G.S. Makker"

Electrophysiological investigation of motor axonal excitability in a mouse model of nerve constriction injury

Autor: Preet G.S. Makker, James Howells, Justin G. Lees, Brooke A Keating, Gila Moalem-Taylor, David Burke

Publikováno v: Journal of the Peripheral Nervous System. 26:99-112

Peripheral nerve injuries caused by focal constriction are characterised by local nerve ischaemia, axonal degeneration, demyelination, and neuroinflammation. The aim of this study was to understand temporal changes in the excitability properties of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e67a6c6957acb0ea055c75eeabbdac6
https://doi.org/10.1111/jns.12430

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Acute changes in nerve excitability following oxaliplatin treatment in mice

Autor: Jasneet Parmar, James Howells, Daniel White, David Goldstein, Susanna B. Park, Justin G. Lees, Preet G.S. Makker, Gila Moalem-Taylor

Publikováno v: Journal of Neurophysiology. 124:232-244

Oxaliplatin chemotherapy produces acute changes in peripheral nerve excitability in humans by modulating voltage-gated Na+ channel activity. However, there are few animal studies of oxaliplatin-induced neuropathy that demonstrate similar changes in e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d69c7b8ad1442d3db325792933bf91
https://doi.org/10.1152/jn.00260.2020

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Regulatory T Cells and Their Derived Cytokine, Interleukin-35, Reduce Pain in Experimental Autoimmune Encephalomyelitis

Autor: Pascal Carrive, Samuel S. Duffy, Oleg Butovsky, Gila Moalem-Taylor, Preet G.S. Makker, Ryan S. Tonkin, Brooke A Keating, Justin G. Lees, Chamini J. Perera

Publikováno v: The Journal of Neuroscience. 39:2326-2346

Sensory problems such as neuropathic pain are common and debilitating symptoms in multiple sclerosis (MS), an autoimmune inflammatory disorder of the CNS. Regulatory T (Treg) cells are critical for maintaining immune homeostasis, but their role in MS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2c609efa868fdb43dadb1d036f2ebd
https://doi.org/10.1523/jneurosci.1815-18.2019

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Cutaneous Neuroimmune Interactions in Peripheral Neuropathic Pain States

Autor: Daniel B. Lowy, Preet G.S. Makker, Gila Moalem-Taylor

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)

Bidirectional interplay between the peripheral immune and nervous systems plays a crucial role in maintaining homeostasis and responding to noxious stimuli. This crosstalk is facilitated by a variety of cytokines, inflammatory mediators and neuropept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c0f0513e3e01f1b0b56be4ed0beda8
http://europepmc.org/articles/PMC8071857

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A unified model of the excitability of mouse sensory and motor axons

Autor: James Howells, Justin G. Lees, Matthew C. Kiernan, Gila Moalem-Taylor, José Manuel Matamala, Susanna B. Park, David Burke, Preet G.S. Makker

Publikováno v: Journal of the Peripheral Nervous System. 23:159-173

Non-invasive nerve excitability techniques have provided valuable insight into the understanding of neurological disorders. The widespread use of mice in translational research on peripheral nerve disorders and by pharmaceutical companies during drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7863bfcede2f771c82a1abc7a0c674e5
https://doi.org/10.1111/jns.12278

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Immune-mediated processes implicated in chemotherapy-induced peripheral neuropathy

Autor: Justin G. Lees, Susanna B. Park, David Goldstein, Ryan S. Tonkin, Gila Moalem-Taylor, Munawwar Abdulla, Preet G.S. Makker

Publikováno v: European Journal of Cancer. 73:22-29

Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain are challenging complications of cancer treatment. Many of the major classes of chemotherapeutics can cause neurotoxicity and significantly modulate the immune system.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d36ccdba6abbedf7aa8763d9ebb6d9c
https://doi.org/10.1016/j.ejca.2016.12.006

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Oxaliplatin induces muscle loss and muscle-specific molecular changes in Mice

Autor: Preet G.S. Makker, David Goldstein, Justin G. Lees, Gila Moalem-Taylor, Patsie Polly, Claire E. Feather, John B.J. Kwok

Publikováno v: Musclenerve. 57(4)

Introduction: Muscle wasting is a frequent, debilitating complication of cancer. The impact of colorectal cancer chemotherapeutic oxaliplatin on the development of muscle loss and associated molecular changes is of clinical importance. Methods: C57BL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60a64a07f2d0dfee67683927e7e3b80
https://pubmed.ncbi.nlm.nih.gov/28881481

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Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice

Autor: Chamini J. Perera, Preet G.S. Makker, Anthony S. Don, Thomas Fath, Justin G. Lees, Samuel S. Duffy, Brooke A Keating, Ryan S. Tonkin, Simon J. O'Carroll, Louise F.B. Nicholson, Collin Tran, Gila Moalem-Taylor, Callum Bowles, Lu Liu, Catherine A. Gorrie, Colin R. Green

Publikováno v: Experimental neurology. 300

© 2017 Elsevier Inc. Connexin43 (Cx43) hemichannels in spinal cord astrocytes are implicated in the maintenance of neuropathic pain following peripheral nerve injury. Peptide5 is a Cx43 mimetic peptide that blocks hemichannels. In this study, we inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d980cc3ca48d1cad0cc03256a48203f
https://pubmed.ncbi.nlm.nih.gov/29055716

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Characterisation of Immune and Neuroinflammatory Changes Associated with Chemotherapy-Induced Peripheral Neuropathy

Autor: Oleg Butovsky, Gila Moalem-Taylor, Susanna B. Park, Ryan S. Tonkin, David Goldstein, Justin G. Lees, Samuel S. Duffy, Preet G.S. Makker, Chamini J. Perera

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0170814 (2017)
PLoS ONE

Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain is a debilitating adverse effect of cancer treatment. Current understanding of the mechanisms underpinning CIPN is limited and there are no effective treatment strategi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e59b302ea3b6a0800d56888488e455
http://europepmc.org/articles/PMC5268425?pdf=render

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Peripheral and central neuroinflammatory changes and pain behaviours in an animal model of multiple sclerosis

Autor: Justin G. Lees, Chamini J. Perera, Preet G.S. Makker, Pascal Carrive, Gila Moalem-Taylor, Samuel S. Duffy

Publikováno v: Frontiers in Immunology, Vol 7 (2016)
Frontiers in Immunology

Pain is a widespread and debilitating symptom of multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system. Although central neuroinflammation and demyelination have been implicated in MS-related pain, the co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e6449cafd0e7afc1c136d6413c07df
http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00369/full

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