Zobrazeno 1 - 10
of 1 707
pro vyhledávání: '"Precursor mRNA"'
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Breast cancer (BC), as a highly prevalent malignant tumor worldwide, is still unclear in its pathogenesis and has poor therapeutic outcomes. Alternative polyadenylation (APA) is a post-transcriptional regulatory mechanism widely found in eukaryotes.
Externí odkaz:
https://doaj.org/article/5bf600eaae864242b0235a156537aedd
Autor:
Gourisankar Ghosh, Kaushik Saha
Publikováno v:
Nucleic Acids Research. 50:8262-8278
We recently reported that serine-arginine-rich (SR) protein-mediated pre-mRNA structural remodeling generates a pre-mRNA 3D structural scaffold that is stably recognized by the early spliceosomal components. However, the intermediate steps between th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9026f0f6bcff93a72325e8de9cd6b800
https://doi.org/10.1093/nar/gkac636
https://doi.org/10.1093/nar/gkac636
Publikováno v:
Genes and Development
3’-end processing of most human mRNAs is carried out by the cleavage and polyadenylation specificity factor (CPSF; CPF in yeast). Endonucleolytic cleavage of the nascent pre-mRNA defines the 3’-end of the mature transcript, which is important for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1238549b4ecefe5f82e054bfb2c14093
https://doi.org/10.1101/gad.349223.121
https://doi.org/10.1101/gad.349223.121
Publikováno v:
International Journal of Biological Macromolecules. 193:387-400
In eukaryotes, maturation of pre-mRNA relies on its precise 3'-end processing. This processing involves co-transcriptional steps regulated by sequence elements and other proteins. Although, it holds tremendous importance, defect in the processing mac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758662e8b57edd4637b25d7e3c64fd5a
https://doi.org/10.1016/j.ijbiomac.2021.10.129
https://doi.org/10.1016/j.ijbiomac.2021.10.129
Akademický článek
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Autor:
Min Su, Jumei Zhou, Shaolin Nie, Yanyan Tang, Yingbin Hu, Junhong Chen, Jie Gu, Rui Tang, Lianqing Zhou, Yujuan Zhou, Jiarui Jiang, Yongyi Chen, Qianjin Liao, Mengtian Tang, Wei Xiong, Zhiqiang Liao
Publikováno v:
Journal of Cellular Physiology. 237:373-388
Circular RNAs (circRNAs) are closed back-splicing products of precursor mRNA in eukaryotes. Compared with linear mRNAs, circRNAs have a special structure and stable expression. A large number of studies have provided different regulatory mechanisms o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0307f94b3ed1c2e4441bcda7a6e701b8
https://doi.org/10.1002/jcp.30608
https://doi.org/10.1002/jcp.30608
Autor:
Nan Wu, Albert Yee, Ling Fang, Jian Ma, Burton B. Yang, Kaixuan Zeng, William W. Du, Juanjuan Lyu
Publikováno v:
Mol Ther
Circular RNAs (circRNAs) represent a large group of non-coding RNAs that are widely detected in mammalian cells. Although most circRNAs are generated in a sense orientation, there is a group of circRNAs that are synthesized in an antisense orientatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d02a5d14304cc6c596bbf833c6aeae3
https://doi.org/10.1016/j.ymthe.2021.08.002
https://doi.org/10.1016/j.ymthe.2021.08.002
Autor:
Vinay Kumar, Zhenwei Zhang, Norbert Rigo, Jean-Baptiste Fourmann, Cindy L. Will, Reinhard Lührmann, Henning Urlaub, Olexandr Dybkov, Holger Stark
Publikováno v:
Nature
During the splicing of introns from precursor messenger RNAs (pre-mRNAs), the U2 small nuclear ribonucleoprotein (snRNP) must undergo stable integration into the spliceosomal A complex—a poorly understood, multistep process that is facilitated by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a4a57e53f03a2f6a2ade532cec6a90
https://doi.org/10.1038/s41586-021-03789-5
https://doi.org/10.1038/s41586-021-03789-5
Publikováno v:
Plant and Cell Physiology
Chloroplast genomes in land plants include approximately 20 intron-containing genes. Most of the introns are similar to the group II introns found in fungi, algae and some bacteria, but no self-splicing has been reported. To analyze splicing reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29958882ebf2f756401401c4b1083cd
http://europepmc.org/articles/PMC8579278
http://europepmc.org/articles/PMC8579278
Autor:
Hao Wang, Dangdang Li, Jinming Shi, Daniel B. Stovall, Yige Qi, Guangchao Sui, Jialiang Li, Ke Shi, Yao Lu, Guangyue Li
Publikováno v:
RNA Biology. 18:318-336
Among the three DMTF1 splicing isoforms, DMTF1α acts as a tumour suppressor through promoting p14ARF expression, while DMTF1β exhibits an oncogenic role likely through antagonizing DMTF1α. However,...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c43ec144bd012aaf27bf7937911bdeb0
https://doi.org/10.1080/15476286.2021.1947644
https://doi.org/10.1080/15476286.2021.1947644