Zobrazeno 1 - 10
of 1 473
pro vyhledávání: '"Preclinical study"'
Publikováno v:
Bulletin of the National Research Centre, Vol 48, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/0fba22d7a330455a97d717c42db02d19
Autor:
Ya-Nan Gao, Hong-Tao Yang, Zi-Feng Qiu, Feng Qi, Qian-Hong Lu, Jian-Feng Zheng, Zi-Wei Xi, Xin Wang, Li Li, Gui Zhang, De-Yuan Zhang, Yu-Die Lu, Hai-Ping Qi, Hong Qiu, Run-Lin Gao, Yu-Feng Zheng
Publikováno v:
Bioactive Materials, Vol 39, Iss , Pp 135-146 (2024)
Iron is considered as an attractive alternative material for bioresorbable scaffolds (BRS). The sirolimus eluting iron bioresorbable scaffold (IBS), developed by Biotyx Medical (Shenzhen, China), is the only iron-based BRS with an ultrathin-wall desi
Externí odkaz:
https://doaj.org/article/f62a9a8a4bae4e0b86a2d5719dadc884
Publikováno v:
Pharmaceutical Biology, Vol 62, Iss 1, Pp 702-712 (2024)
Context Diabetic nephropathy (DN) is a major complication of diabetes mellitus and is the leading cause of kidney disease in patients undergoing renal replacement therapy. DN is associated with an increased risk of death in patients with diabetes. Co
Externí odkaz:
https://doaj.org/article/7c0e4614b96d4853b8518c5f1c0b55da
Publikováno v:
Laboratory Animal Research, Vol 40, Iss 1, Pp 1-18 (2024)
Abstract Scientific progress heavily relies on rigorous research, adherence to scientific standards, and transparent reporting. Animal models play a crucial role in advancing biomedical research, especially in the field of gene therapy. Animal models
Externí odkaz:
https://doaj.org/article/4cb035ec6ea349f19428709a270672c3
Autor:
Paul Tamburini, Dennis Vestergaard Pedersen, Denise Devore, Josh Cone, Rekha Patel, Todd Hunter, Fang Sun, Gregers Rom Andersen, Jeffrey Hunter
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
The bispecific antibody tarperprumig (ALXN1820) was developed as a treatment option for diseases involving dysregulated complement alternative pathway (AP) activity that could be administered in small volumes, either subcutaneously or intravenously.
Externí odkaz:
https://doaj.org/article/753bc6a4e1c84f36a3a965b0c849a86b
Autor:
Xiaoyan Tian, Kunling Fu, Xuemin Huang, Haiyan Zou, Nianmei Shi, Jiayang Li, Yuxiang Bao, Sisi He, Junyuan Lv
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Ferroptosis represents a distinct form of cell death that is not associated with necrosis, autophagy, apoptosis, or pyroptosis. It is characterised by intracellular iron-dependent lipid peroxidation. The current literature indicates that a number of
Externí odkaz:
https://doaj.org/article/7d89b0c3983d4955a88eb894bb36debb
Autor:
Mari Carmen Gómez-de Frutos, Fernando Laso-García, Iván García-Suárez, Dolores Piniella, Laura Otero-Ortega, Elisa Alonso-López, Javier Pozo-Novoa, Rebeca Gallego-Ruiz, Nerea Díaz-Gamero, Blanca Fuentes, María Alonso de Leciñana, Exuperio Díez-Tejedor, Gerardo Ruiz-Ares, María Gutiérrez-Fernández
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116834- (2024)
Although diabetes mellitus negatively affects post-ischaemic stroke injury and recovery, its impact on intracerebral haemorrhage (ICH) remains uncertain. This study aimed to investigate the effect of experimental diabetes (ED) on ICH-induced injury a
Externí odkaz:
https://doaj.org/article/45d086373bd449ffaefe9fd5fd305989
Autor:
Binghao J. Peng, Andrea Alvarado, Hangameh Cassim, Soprina Guarneri, Steven Wong, Jonathan Willis, Julia SantaMaria, Ashley Martynchuk, Victoria Stratton, Darshil Patel, Chien-Chung Chen, Yan Li, Gwendolyn K. Binder, Rebecca Dryer-Minnerly, Jinmin Lee, Samik Basu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101267- (2024)
Over 4% of the global population is estimated to live with autoimmune disease, necessitating immunosuppressive treatment that is often chronic, not curative, and carries associated risks. B cells have emerged as key players in disease pathogenesis, a
Externí odkaz:
https://doaj.org/article/7360e7cc852147cfa8c7798aa6721709
Autor:
V. V. Zarubaev, A. V. Garshinina, Ya. L. Esaulkova, M. G. Mihalskij, V. S. Smirnov, T. A. Kudryavtseva, S. V. Petlenko, V. A. Zaplutanov
Publikováno v:
Антибиотики и Химиотерапия, Vol 68, Iss 9-10, Pp 46-57 (2024)
Introduction. Due to the ability of the influenza virus to mutate, it is necessary to constantly search for new drugs with preventive and direct antiviral effects.The aim of the study is to investigate the protective antiviral properties of the drug
Externí odkaz:
https://doaj.org/article/60db99eb251f4c8b8799e1291ec718c2
Publikováno v:
Irish Veterinary Journal, Vol 76, Iss 1, Pp 1-13 (2023)
Abstract Background The overall confidence in the results of systematic reviews including animal models can be heterogeneous. We assessed the methodological quality of systematic reviews including animal models in dentistry as well as the overall con
Externí odkaz:
https://doaj.org/article/fc7ee7df8abb4edab24ad6d281c6709c