Zobrazeno 1 - 10
of 3 359
pro vyhledávání: '"Preclinical research"'
Publikováno v:
Addiction. Jun2022, Vol. 117 Issue 6, p1820-1822. 3p.
Publikováno v:
ESC Heart Failure, Vol 11, Iss 3, Pp 1283-1289 (2024)
Abstract Heart failure is a devastating syndrome affecting an increasingly high number of patients worldwide. Its aetiology and pathogenesis are complex with the involvement of factors ranging from the genetic material through valvular dysfunctions t
Externí odkaz:
https://doaj.org/article/e0af5814423a4274a366a42adfd40ecb
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Silent information regulator 1 (SIRT1) is a NAD+-dependent class III deacetylase that plays important roles in the pathogenesis of numerous diseases, positioning it as a prime candidate for therapeutic intervention. Among its modulators, SRT
Externí odkaz:
https://doaj.org/article/fbe62b859aaa4faa9a9137cf127c20cc
Autor:
Hanwei Yue, Lin Bai
Publikováno v:
Animal Models and Experimental Medicine, Vol 7, Iss 1, Pp 3-11 (2024)
Abstract In recent years, humanized immune system (HIS) mice have been gradually used as models for preclinical research in pharmacotherapies and cell therapies with major breakthroughs in tumor and other fields, better mimicking the human immune sys
Externí odkaz:
https://doaj.org/article/10057c4c05974220b25d87db6ac0b08c
Autor:
Manoj M. Lalu, Dawn Richards, Madison Foster, Brittany French, Angela M. Crawley, Kirsten M. Fiest, Kathryn Hendrick, Kimberly F. Macala, Asher A. Mendelson, Pat Messner, Stuart G. Nicholls, Justin Presseau, Cheryle A. Séguin, Patrick Sullivan, Bernard Thébaud, Dean A. Fergusson
Publikováno v:
Research Involvement and Engagement, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Background Patient engagement in research is the meaningful and collaborative interaction between patients and researchers throughout the research process. Patient engagement can help to ensure patient-oriented values and perspectives are in
Externí odkaz:
https://doaj.org/article/d1346b77fe94404e9245270fe80b7977
Autor:
Alexandra Bannach-Brown, Torsten Rackoll, Nurcennet Kaynak, Natascha Drude, René Aquarius, Sofija Vojvodić, Mariana Abreu, Julia M. L. Menon, Kimberley E. Wever
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Systematic reviews are an essential tool in identifying knowledge gaps and synthesizing evidence from in vivo animal research to improve human health. The review process follows an explicit and systematic methodology to minimize bias, but is
Externí odkaz:
https://doaj.org/article/f3a29a5051a84b2b924dbd2ba561f5f6
Autor:
Thomas Hartung
Publikováno v:
Frontiers in Drug Discovery, Vol 4 (2024)
Animals like mice and rats have long been used in medical research to help understand disease and test potential new treatments before human trials. However, while animal studies have contributed to important advances, too much reliance on animal mod
Externí odkaz:
https://doaj.org/article/d6c68c28933a414db9c90ffa3f8e778d
Autor:
Adrienne B. Narrowe, Johanna M. S. Lemons, Karley K. Mahalak, Jenni Firrman, Pieter Van den Abbeele, Aurélien Baudot, Stef Deyaert, Yanfang Li, Liangli (Lucy) Yu, LinShu Liu
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
The genus Senna contains globally distributed plant species of which the leaves, roots, and seeds have multiple traditional medicinal and nutritional uses. Notable chemical compounds derived from Senna spp. include sennosides and emodin which have be
Externí odkaz:
https://doaj.org/article/5fc658b665e942ed9c17f9054793756f
Autor:
Monica J. Justice
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/a9d4c341fead4b1d864ce7bb170a52ac
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 5 (2024)
Background Delayed cerebral ischemia represents a significant contributor to death and disability following aneurysmal subarachnoid hemorrhage. Although preclinical models have shown promising results, clinical trials have consistently failed to repl
Externí odkaz:
https://doaj.org/article/c09f27e5976f4928bb2ca59f33400248