Zobrazeno 1 - 10
of 390
pro vyhledávání: '"Precision-cut lung slices"'
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-21 (2024)
Abstract Precision Cut Lung Slices (PCLS) have emerged as a sophisticated and physiologically relevant ex vivo model for studying the intricacies of lung diseases, including fibrosis, injury, repair, and host defense mechanisms. This innovative metho
Externí odkaz:
https://doaj.org/article/71f7ddc284e4473cb3c3dcf06f33ca55
Autor:
Magali Boucher, Cyndi Henry, Louis Gélinas, Rosalie Packwood, Andrés Rojas-Ruiz, Liah Fereydoonzad, Percival Graham, Ynuk Bossé
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The level of airway constriction in thin slices of lung tissue is highly variable. Owing to the labor-intensive nature of these experiments, determining the number of airways to be analyzed in order to allocate a reliable value of constricti
Externí odkaz:
https://doaj.org/article/637cd8a18c8343308419698a40b24834
Autor:
Shuxian Li, Yabin Lu, Shanshan Yang, Caiying Wang, Jing Yang, Xin Huang, Guohui Chen, Yongheng Shao, Maolin Li, Haoyuan Yu, Yuguang Fu, Guangliang Liu
Publikováno v:
AMB Express, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Respiratory coronaviruses (RCoVs) significantly threaten human health, necessitating the development of an ex vivo respiratory culture system for investigating RCoVs infection. Here, we successfully generated a porcine precision-cut lung sli
Externí odkaz:
https://doaj.org/article/f1c601001a4849e2804ecf5fa31e5cb9
Autor:
Charline Sommer, Stella Marie Reamon-Buettner, Monika Niehof, Christina Beatrix Hildebrand, Armin Braun, Katherina Sewald, Susann Dehmel, Christina Brandenberger
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Aging is associated with an increased incidence and mortality of Pseudomonas aeruginosa-induced pneumonias. This might be partly due to age-dependent increases in inflammatory mediators, referred to as inflamm-aging and a decline
Externí odkaz:
https://doaj.org/article/533b9c8caabe48f8925d0807efe3488e
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-2 (2024)
Abstract Publications utilizing precision cut lung slices (PCLS) steadily increased from the 1970’s, with a significant increase in 2010, to tripling by 2023. PCLS have been used to study a vast array of pulmonary diseases and exposures to pathogen
Externí odkaz:
https://doaj.org/article/e6b7103fd07444f9bf13d3f50e0c0556
Autor:
Olga A. Nev, Lucian Duvenage, Alistair J. P. Brown, Rachael Dangarembizi, Jennifer Claire Hoving
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Pneumocystis jirovecii is a major fungal pathogen of humans that causes life-threatening lung infections in immunocompromised individuals. Despite its huge global impact upon human health, our understanding of the pathobiology of this deadly
Externí odkaz:
https://doaj.org/article/9301b7f1ebed475895bce4014f51a630
Autor:
Carmen A. Moes, C. Tji Gan, Leonie H. Venema, Roland F. Hoffmann, Barbro N. Melgert, Huib A. M. Kerstjens, Peter Olinga, Mitchel J. R. Ruigrok
Publikováno v:
Transplantology, Vol 4, Iss 4, Pp 185-196 (2023)
Background: Donor lungs are often discarded, with gastric aspiration accounting for ~9% of lungs unsuitable for transplantation. To increase the donor pool, it is important to understand the pathophysiology of aspiration-induced lung damage (AILD) an
Externí odkaz:
https://doaj.org/article/701914ac0e3b4994bb04ea75d7718910
Autor:
Sara Bozzini, Eleonora Bozza, Cecilia Bagnera, Patrizia Morbini, Sara Lettieri, Matteo Della Zoppa, Giulio Melloni, Laura Saracino, Mirko Belliato, Federica Meloni
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8186 (2024)
Recent studies have emphasized the critical role of alteration in cellular plasticity in the development of fibrotic disorders, particularly pulmonary fibrosis, prompting further investigation into molecular mechanisms and therapeutic approaches. In
Externí odkaz:
https://doaj.org/article/af7e3c40c76441e7aa1a4bc37624b62e
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Many adult lung diseases involve dysregulated lung repair. Deciphering the molecular and cellular mechanisms that govern intrinsic lung repair is essential to develop new treatments to repair/regenerate the lungs. Aberrant Wnt signalling is associate
Externí odkaz:
https://doaj.org/article/6606e06488e942ffba876151e4d73e15
Autor:
Katherine E. Stephenson, Joanne Porte, Aoife Kelly, William A. Wallace, Catherine E. Huntington, Catherine L. Overed-Sayer, E. Suzanne Cohen, R. Gisli Jenkins, Alison E. John
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease (ILD) with limited treatment options. Interleukin-33 (IL-33) is proposed to play a role in the development of IPF however the exclusive use of prophyla
Externí odkaz:
https://doaj.org/article/75bb0ba23cf7458cbe360a62e4dff65c