Dry Generation of CeO2 Nanoparticles and Deposition onto a Co-Culture of A549 and THP-1 Cells in Air-Liquid Interface—Dosimetry Considerations and Comparison to Submerged Exposure

Autor: Francesca Cappellini, Sebastiano Di Bucchianico, Venkatanaidu Karri, Siiri Latvala, Maria Malmlöf, Maria Kippler, Karine Elihn, Jonas Hedberg, Inger Odnevall Wallinder, Per Gerde, Hanna L. Karlsson

Publikováno v: Nanomaterials, Vol 10, Iss 4, p 618 (2020)

Relevant in vitro assays that can simulate exposure to nanoparticles (NPs) via inhalation are urgently needed. Presently, the most common method employed is to expose lung cells under submerged conditions, but the cellular responses to NPs under such

Externí odkaz: https://doaj.org/article/24ed020eb87c4b6da77d8173f0444817

Adapting the Aerogen Mesh Nebulizer for Dried Aerosol Exposures Using the PreciseInhale Platform

Autor: Per Gerde, Mattias Nowenwik, Carl-Olof Sjöberg, Ewa Selg

Publikováno v: Journal of Aerosol Medicine and Pulmonary Drug Delivery

Background: Many substances used in inhalation research are water soluble and can be administered as nebulized solutions. Typical examples are therapeutic, small-molecular agents, or macromolecules. Another category is a number of water-soluble agent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2199fd5f24594a766ff92be1dbd1ca
http://europepmc.org/articles/PMC7133437

Use of PBPK Modeling to Evaluate the Performance of Dissolv It, a Biorelevant Dissolution Assay for Orally Inhaled Drug Products

Autor: Hassoun, Mireille, Malmlöf, Maria, Scheibelhofer, Otto, Kumar, Abhinav, Bansal, Sukhi, Selg, Ewa, Nowenwik, Mattias, Gerde, Per, Radivojev, Snezana, Paudel, Amrit, Arora, Sumit, Forbes, Ben

Publikováno v: Hassoun, M, Malmlof, M, Scheibelhofer, O, Kumar, A, Bansal, S, Selg, E, Nowenwik, M, Gerde, P, Radivojev, S, Paudel, A, Arora, S & Forbes, B 2019, ' Use of PBPK Modeling to Evaluate the Performance of Dissolv It, a Biorelevant Dissolution Assay for Orally Inhaled Drug Products ', Molecular Pharmaceutics, vol. 16, no. 3, pp. 1245-1254 . https://doi.org/10.1021/acs.molpharmaceut.8b01200

[Image: see text] The dissolution of inhaled drug particles in the lungs is a challenge to model using biorelevant methods in terms of (i) collecting a respirable emitted aerosol fraction and dose, (ii) presenting this to a small volume of medium tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::606692f6f0809f7144f1e540ded64bef
https://kclpure.kcl.ac.uk/ws/files/104744791/Use_of_PBPK_modelling_to_HASSOUN_Publishedonline14January2019_GREEN_AAM.pdf

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