CYTOGENETIC STUDIES IN HAEMATOLOGICAL DISORDERS WHICH MAY TERMINATE IN ACUTE LEUKAEMIA

Autor: Preben Philip, Mogens Krogh Jensen

Publikováno v: Acta Medica Scandinavica. 193:353-357

Cytogenetic studies have been performed in 35 patients with potentially leukaemic haematological disorders. Abnormal stem lines were present in six patients, three of whom died from leukaemia or aggressive myelofibrosis within a few months. One patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866d2ed85e23fbf067088cc266c106c1
https://doi.org/10.1111/j.0954-6820.1973.tb10590.x

Mafosfamide (ASTA-Z-7654) in vitro treatment of bone marrow does not eradicate Philadelphia-positive cells in chronic myeloid leukaemia

Autor: P. Ernst, Preben Philip, B. T. Mortensen

Publikováno v: European Journal of Haematology. 41:218-222

Bone marrow from 9 patients with Ph1 + CML was treated in vitro with varying concentrations of Mafosfamide in order to test the hypothesis that selective pharmacological killing of Ph1-positive cells in CML is feasible. A marked difference in sensiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6ae2b9ca8a394892e39fc0698f7610
https://doi.org/10.1111/j.1600-0609.1988.tb01184.x

Therapy-related malignancies: A review

Autor: Jens Pedersen-Bjergaard, Preben Philip

Publikováno v: European Journal of Haematology. 42:39-47

Although many cytostatic drugs have been shown to be both mutagenic and carcinogenic in experimental systems, only the alkylating agents have been demonstrated with certainty to induce malignancy in man. Thus, therapy with almost all alkylating agent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d649abee2d9c05b54c58b37189c801
https://doi.org/10.1111/j.1600-0609.1989.tb01237.x

Tamoxifen for one year versus two years versus 6 months of Tamoxifen and 6 months of megestrol acetate: A randomized comparison in postmenopausal patients with high-risk breast cancer (DBCG 89C)

Autor: Søren Cold, Susanne Møller, Preben Philip, Claus Kamby, Knud Aage Møller, Erik H Jacobsen, Bent Ejlertsen, Disa Jensen, Marianne Ewertz, Jørn Andersen

Publikováno v: Andersen, J, Kamby, C, Ejlertsen, B, Cold, S, Ewertz, M, Jacobsen, E H, Philip, P, Møller, K A, Jensen, D & Møller, S 2008, ' Tamoxifen for one year versus two years versus 6 months of Tamoxifen and 6 months of megestrol acetate: a randomized comparison in postmenopausal patients with high-risk breast cancer (DBCG 89C) ', Acta Oncologica, vol. 47, no. 4, pp. 718-24 . https://doi.org/10.1080/02841860802014882
Andersen, J, Kamby, C, Ejlertsen, B, Cold, S, Ewertz, M, Jacobsen, E H, Philip, P, Møller, K A, Jensen, D & Møller, S 2008, ' Tamoxifen for one year versus two years versus 6 months of Tamoxifen and 6 months of megestrol acetate : a randomized comparison in postmenopausal patients with high-risk breast cancer (DBCG 89C) ', Acta Oncologica, vol. 47, no. 4, pp. 718-724 . https://doi.org/10.1080/02841860802014882

Udgivelsesdato: 2008 From January 1, 1990 to December 31, 1994, DBCG conducted a randomised trial in 1 615 postmenopausal women with operable, high-risk, receptor-positive or -unknown breast cancer. The patients were after surgery randomised to Tamox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b5da53625a10027afe115029a604de
https://doi.org/10.1080/02841860802014882

In B-cell chronic lymphocytic leukaemia chromosome 17 abnormalities and not trisomy 12 are the single most important cytogenetic abnormalities for the prognosis: A cytogenetic and immunophenotypic study of 480 unselected newly diagnosed patients

Autor: Preben Philip, Erik Andersen, Klaus Hou-Jensen, O. Myhre Jensen, Jørgen Ellegaard, Henrik Birgens, K. Thorling, Aage Drivsholm, B. Egelund Christensen, Peter de Nully Brown, P. Kragh Andersen, Torben Plesner, Jørgen K. Larsen, Carsten Geisler, M. M. Hansen, N. Tinggaard Pedersen

Publikováno v: Leukemia Research. 21:1011-1023

Of 560 consecutive, newly diagnosed untreated patients with B CLL submitted for chromosome study, G-banded karyotypes could be obtained in 480 cases (86%). Of these, 345 (72%) had normal karyotypes and 135 (28%) had clonal chromosome abnormalities: t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a6b7c0cbeca7e771da02615a5ee773
https://doi.org/10.1016/s0145-2126(97)00095-7