Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients

Autor: Cécile Alanio, Francesco Nicoli, Philippe Sultanik, Tobias Flecken, Brieuc Perot, Darragh Duffy, Elisabetta Bianchi, Annick Lim, Emmanuel Clave, Marit M van Buuren, Aurélie Schnuriger, Kerstin Johnsson, Jeremy Boussier, Antoine Garbarg-Chenon, Laurence Bousquet, Estelle Mottez, Ton N Schumacher, Antoine Toubert, Victor Appay, Farhad Heshmati, Robert Thimme, Stanislas Pol, Vincent Mallet, Matthew L Albert

Publikováno v: eLife, Vol 4 (2015)

Chronic infection perturbs immune homeostasis. While prior studies have reported dysregulation of effector and memory cells, little is known about the effects on naïve T cell populations. We performed a cross-sectional study of chronic hepatitis C (

Externí odkaz: https://doaj.org/article/d89d3f83b9d7475b9d4f81ba46b5ec3d

Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients

Autor: Tobias Flecken, Jeremy Boussier, Farhad Heshmati, Vincent Mallet, Marit M. van Buuren, Francesco Nicoli, Matthew L. Albert, Aurélie Schnuriger, Ton N. Schumacher, Philippe Sultanik, Laurence Bousquet, Elisabetta Bianchi, Robert Thimme, Annick Lim, A. Garbarg-Chenon, Darragh Duffy, Antoine Toubert, Kerstin Johnsson, Emmanuel Clave, Stanislas Pol, Estelle Mottez, Cécile Alanio, Brieuc Perot, Victor Appay

Publikováno v: eLife
eLife, eLife Sciences Publication, 2015, 4, pp.e07916. ⟨10.7554/eLife.07916⟩
eLife, 2015, 4, pp.e07916. ⟨10.7554/eLife.07916⟩
eLife, eLife Sciences Publication, 2015, 4, pp.e07916. 〈10.7554/eLife.07916〉
eLife, Vol 4 (2015)

Chronic infection perturbs immune homeostasis. While prior studies have reported dysregulation of effector and memory cells, little is known about the effects on naïve T cell populations. We performed a cross-sectional study of chronic hepatitis C (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06b2865cf6d3237f33d84a47e5edb6c
https://hal.sorbonne-universite.fr/hal-01306801/document

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Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients.

Autor: Alanio C; Unités de Recherche Internationales Mixtes Pasteur, Institut Pasteur, Paris, France.; Centre d'Immunologie Humaine, Institut Pasteur, Paris, France.; Immunobiology of Dendritic Cells, Institut Pasteur, Paris, France., Nicoli F; Sorbonne Universités, UPMC Univ Paris 06, DNU FAST, CR7, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.; Emory, , United States., Sultanik P; Unités de Recherche Internationales Mixtes Pasteur, Institut Pasteur, Paris, France.; Immunobiology of Dendritic Cells, Institut Pasteur, Paris, France., Flecken T; The University Medical Center Freiburg, Department of Internal Medicine II, Albert-Ludwigs-Universität, Freiberg, Germany., Perot B; Unités de Recherche Internationales Mixtes Pasteur, Institut Pasteur, Paris, France.; Immunobiology of Dendritic Cells, Institut Pasteur, Paris, France., Duffy D; Unités de Recherche Internationales Mixtes Pasteur, Institut Pasteur, Paris, France.; Centre d'Immunologie Humaine, Institut Pasteur, Paris, France.; Immunobiology of Dendritic Cells, Institut Pasteur, Paris, France., Bianchi E; Immunoregulation Unit, Institut Pasteur, Paris, France., Lim A; Plateforme d'Immunoscope, Institut Pasteur, Paris, France., Clave E; Hôpital Saint-Louis, Assistance publique - hôpitaux de Paris, Paris, France., van Buuren MM; Department of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Schnuriger A; Laboratoire de virologie, Hôpital Armand-Trousseau, Assistance publique - hôpitaux de Paris, Paris, France., Johnsson K; Mathematics, Faculty of Engineering, Lunds University, Lund, Sweden., Boussier J; Unités de Recherche Internationales Mixtes Pasteur, Institut Pasteur, Paris, France.; Centre d'Immunologie Humaine, Institut Pasteur, Paris, France.; Immunobiology of Dendritic Cells, Institut Pasteur, Paris, France., Garbarg-Chenon A; Laboratoire de virologie, Hôpital Armand-Trousseau, Assistance publique - hôpitaux de Paris, Paris, France., Bousquet L; APHP, Université Paris Descartes, Paris, France., Mottez E; Centre d'Immunologie Humaine, Institut Pasteur, Paris, France., Schumacher TN; Department of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Toubert A; Hôpital Saint-Louis, Assistance publique - hôpitaux de Paris, Paris, France., Appay V; Sorbonne Universités, UPMC Univ Paris 06, DNU FAST, CR7, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.; Emory, , United States., Heshmati F; EFS, Hôpital Cochin, Paris, France., Thimme R; The University Medical Center Freiburg, Department of Internal Medicine II, Albert-Ludwigs-Universität, Freiberg, Germany., Pol S; APHP, Université Paris Descartes, Paris, France., Mallet V; APHP, Université Paris Descartes, Paris, France., Albert ML; Unités de Recherche Internationales Mixtes Pasteur, Institut Pasteur, Paris, France.; Centre d'Immunologie Humaine, Institut Pasteur, Paris, France.; Immunobiology of Dendritic Cells, Institut Pasteur, Paris, France.

Publikováno v: ELife [Elife] 2015 Nov 14; Vol. 4. Date of Electronic Publication: 2015 Nov 14.