Zobrazeno 1 - 10
of 366
pro vyhledávání: '"Pre-clinical models"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background The tumor microenvironment is profoundly heterogeneous particularly when comparing sites of metastases. Establishing the extent of this heterogeneity may provide guidance on how best to design lipid-based drug delivery systems to
Externí odkaz:
https://doaj.org/article/9192e449a6724fde9d21e119bf73a0bd
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Lung cancer remains one of the leading causes of cancer-related mortality worldwide, necessitating innovative research methodologies to improve treatment outcomes and develop novel strategies. The advent of three-dimensional (3D) cell cultures has ma
Externí odkaz:
https://doaj.org/article/0b0570f53e0341d4acb4cd856255aff8
Publikováno v:
JOR Spine, Vol 7, Iss 3, Pp n/a-n/a (2024)
Abstract Chronic low back pain caused by intervertebral disc (IVD) degeneration, also termed chronic discogenic low back pain (CD‐LBP), is one of the most prevalent musculoskeletal diseases. Degenerative processes in the IVD, such as inflammation a
Externí odkaz:
https://doaj.org/article/9cc793035e3b4f1aba792c94c16ccbda
Autor:
Gust Vandecandelaere, Rishab Ramapriyan, Matthew Gaffey, Leland Geoffrey Richardson, Samuel Jeffrey Steuart, Masih Tazhibi, Adrian Kalaw, Eric P. Grewal, Jing Sun, William T. Curry, Bryan D. Choi
Publikováno v:
Cells, Vol 13, Iss 17, p 1480 (2024)
Immunotherapy represents a transformative shift in cancer treatment. Among myriad immune-based approaches, chimeric antigen receptor (CAR) T-cell therapy has shown promising results in treating hematological malignancies. Despite aggressive treatment
Externí odkaz:
https://doaj.org/article/868cd5c799464249a0cfb3e80f9d4e04
Publikováno v:
Exploration of Medicine, Vol 4, Iss 4, Pp 461-470 (2023)
Broncho-alveolar lavage (BAL) represents a safe tool for the differential diagnosis of various pulmonary fibrotic diseases. Idiopathic pulmonary fibrosis (IPF) belongs to a heterogeneous group of diseases, interstitial lung disease (ILD), presenting
Externí odkaz:
https://doaj.org/article/24b9226356864e23b8f53af17312ebb6
Autor:
Elisa Cauli, Michela Anna Polidoro, Simona Marzorati, Claudio Bernardi, Marco Rasponi, Ana Lleo
Publikováno v:
Journal of Biological Engineering, Vol 17, Iss 1, Pp 1-25 (2023)
Abstract The approval of anticancer therapeutic strategies is still slowed down by the lack of models able to faithfully reproduce in vivo cancer physiology. On one hand, the conventional in vitro models fail to recapitulate the organ and tissue stru
Externí odkaz:
https://doaj.org/article/206574081ba44015b2a57f6ffcd399f8
Autor:
Jesse Shen, Nathalie Samson, Jérôme Lamontagne‐Proulx, Denis Soulet, Yves Tremblay, Marc Bazin, Charlène Nadeau, Sarah Bouchard, Jean‐Paul Praud, Stefan Parent
Publikováno v:
JOR Spine, Vol 7, Iss 1, Pp n/a-n/a (2024)
Abstract Background The evolution and treatment of lung alterations related to congenital spine and chest wall deformities (CWD) are poorly understood. Most animal models of CWD created postnatally were not evaluated for respiratory function. The goa
Externí odkaz:
https://doaj.org/article/d877418719b94d94aef1d1e242032c5d
Autor:
Xiaolan Lin, Tian Guan, Yien Xu, Yun Li, Yanchun Lin, Shaobin Chen, Yuping Chen, Xiaolong Wei, Dongsheng Li, Yukun Cui, Yan Lin, Pingnan Sun, Jianmin Guo, Congzhu Li, Jiang Gu, Wei Yang, Haoyu Zeng, Changchun Ma
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionChimeric antigen receptor natural killer (CAR-NK) cells have been found to be successful in treating hematologic malignancies and present potential for usage in solid tumors.MethodsIn this study, we created CD276-targeted CAR-expressing N
Externí odkaz:
https://doaj.org/article/ff8feaad2b98496c8e741cf63e21a294
Autor:
Elisa Heinzelmann, Francesco Piraino, Mariana Costa, Aline Roch, Maxim Norkin, Virginie Garnier, Krisztian Homicsko, Nathalie Brandenberg
Publikováno v:
Current Research in Toxicology, Vol 7, Iss , Pp 100197- (2024)
Recent advancements in stem cell technology have led to the development of organoids – three-dimensional (3D) cell cultures that closely mimic the structural and functional characteristics of human organs. These organoids represent a significant im
Externí odkaz:
https://doaj.org/article/74a490d8ff2245d7a1d6089e57594494
Autor:
Katherine B. Crump, Ahmad Alminnawi, Paola Bermudez‐Lekerika, Roger Compte, Francesco Gualdi, Terence McSweeney, Estefano Muñoz‐Moya, Andrea Nüesch, Liesbet Geris, Stefan Dudli, Jaro Karppinen, Jérôme Noailly, Christine Le Maitre, Benjamin Gantenbein
Publikováno v:
JOR Spine, Vol 6, Iss 4, Pp n/a-n/a (2023)
Abstract The cartilaginous endplates (CEP) are key components of the intervertebral disc (IVD) necessary for sustaining the nutrition of the disc while distributing mechanical loads and preventing the disc from bulging into the adjacent vertebral bod
Externí odkaz:
https://doaj.org/article/5b4478ce19fc4886978a62ecc9211dac