Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Pravindra Kumar"'
Autor:
Harry Kaur, Simranjeet Singh, Sandra Kathott Prakash, Surabhi Rode, Sapna Lonare, Rakesh Kumar, Pravindra Kumar, Ashwani Kumar Sharma, Praveen C. Ramamurthy, Joginder Singh, Nadeem A. Khan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract In the realm of disease vectors and agricultural pest management, insecticides play a crucial role in preserving global health and ensuring food security. The pervasive use, particularly of organophosphates (OPs), has given rise to a substan
Externí odkaz:
https://doaj.org/article/e84ccd17439a49e993655930df06928a
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 25, Iss 7, Pp 1337-1360 (2020)
With rising antibiotic resistance at alarming rates in S. aureus, a major human pathogen, it is important to identify targets for new antimicrobial therapies. A number of two-component systems (TCS) have been implicated in S. aureus resistance to sev
Externí odkaz:
https://doaj.org/article/bc33fab5f5644208b97df25781805e41
Autor:
Pramod Kumar, Pooja Kesari, Sonali Dhindwal, Ashish K. Choudhary, Madhusudhanarao Katiki, Neetu, Aparna Verma, Kiran Ambatipudi, Shailly Tomar, Ashwani Kumar Sharma, Girish Mishra, Pravindra Kumar
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Auxin levels are tightly regulated within the plant cell, and its storage in the isolated cavity of proteins is a measure adopted by cells to maintain the availability of auxin. We report the first crystal structure of Wrightia tinctoria 11S
Externí odkaz:
https://doaj.org/article/6a003f7855e041b2bdbfdcf9262e3c9d
Autor:
Shivendra Pratap, Aditya Dev, Vijay Kumar, Ravi Yadav, Manju Narwal, Shailly Tomar, Pravindra Kumar
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract 3-deoxy-D-arabino-heptulosonate-7-phosphate-synthase (DAHPS) is the first enzyme of the shikimate pathway and is responsible for the synthesis of aromatic amino acids in microorganisms. This pathway is an attractive target for antimicrobial
Externí odkaz:
https://doaj.org/article/7793ed6955424fb5b7078723a9fe03db
Autor:
Christopher L Colbert, Nathalie Y R Agar, Pravindra Kumar, Mathew N Chakko, Sangita C Sinha, Justin B Powlowski, Lindsay D Eltis, Jeffrey T Bolin
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52550 (2013)
The oxidative degradation of biphenyl and polychlorinated biphenyls (PCBs) is initiated in Pandoraea pnomenusa B-356 by biphenyl dioxygenase (BPDO(B356)). BPDO(B356), a heterohexameric (αβ)(3) Rieske oxygenase (RO), catalyzes the insertion of dioxy
Externí odkaz:
https://doaj.org/article/c966707e72074dce8372aa7d536fd341
Autor:
Dipak N Patil, Manali Datta, Aditya Dev, Sonali Dhindwal, Nirpendra Singh, Pushpanjali Dasauni, Suman Kundu, Ashwani K Sharma, Shailly Tomar, Pravindra Kumar
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63779 (2013)
The glycosyl hydrolase 18 (GH18) family consists of active chitinases as well as chitinase like lectins/proteins (CLPs). The CLPs share significant sequence and structural similarities with active chitinases, however, do not display chitinase activit
Externí odkaz:
https://doaj.org/article/eb93287c8420494484cd7baf28eb37cc
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53397 (2013)
Polyamine biosynthetic pathway is a validated therapeutic target for large number of infectious diseases including cancer, giardiasis and African sleeping sickness, etc. α-Difluoromethylornithine (DFMO), a potent drug used for the treatment of Afric
Externí odkaz:
https://doaj.org/article/e673b4aaedc9428abc43e2f0694d134b
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 2, p e1559 (2012)
BACKGROUND: Entamoeba histolytica is responsible for causing amoebiasis. Polyamine biosynthesis pathway enzymes are potential drug targets in parasitic protozoan diseases. The first and rate-limiting step of this pathway is catalyzed by ornithine dec
Externí odkaz:
https://doaj.org/article/4faba332ff6c48d39f149c003e242f99
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30102 (2012)
Expression of KdpFABC, a K(+) pump that restores osmotic balance, is controlled by binding of the response regulator KdpE to a specific DNA sequence (kdpFABC(BS)) via the winged helix-turn-helix type DNA binding domain (KdpE(DBD)). Exploration of E.
Externí odkaz:
https://doaj.org/article/1ef3627edec140e3ba2bf0a425284784
Autor:
Megha Aggarwal, Satya Tapas, Preeti, Anjul Siwach, Pravindra Kumar, Richard J Kuhn, Shailly Tomar
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51288 (2012)
The nucleocapsid core interaction with endodomains of glycoproteins plays a critical role in the alphavirus life cycle that is essential to virus budding. Recent cryo-electron microscopy (cryo-EM) studies provide structural insights into key interact
Externí odkaz:
https://doaj.org/article/f2d1cb1fc8bb43e29a6690bf86e89227