Výsledky vyhledávání - "Pravina M. Patel"

Fractionation of electrograms is caused by colocalized conduction block and connexin disorganization in the absence of fibrosis as AF becomes persistent in the goat model

Autor: Pravina M. Patel, Nicholas S. Peters, Clifford J. Garratt, Rasheda A. Chowdhury, Mark C.S. Hall, Senthil Kirubakaran

Publikováno v: Heart Rhythm

Background Electrogram fractionation and atrial fibrosis are both thought to be pathophysiological hallmarks of evolving persistence of atrial fibrillation (AF), but recent studies in humans have shown that they do not colocalize. The interrelationsh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf0601ad5b0e1e2c78fd2f2a890834a
http://europepmc.org/articles/PMC4315883

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Enhancement of Gap Junction Function During Acute Myocardial Infarction Modifies Healing and Reduces Late Ventricular Arrhythmia Susceptibility

Autor: Fu Siong, Ng, Jeremy M, Kalindjian, Simon A, Cooper, Rasheda A, Chowdhury, Pravina M, Patel, Emmanuel, Dupont, Alexander R, Lyon, Nicholas S, Peters

Publikováno v: Jacc. Clinical Electrophysiology

Objectives The purpose of this study was to investigate the effects of enhancing gap junction (GJ) coupling during acute myocardial infarction (MI) on the healed infarct scar morphology and late post-MI arrhythmia susceptibility. Background Increased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e6c501edb9da927ae412a282f14a05d
https://pubmed.ncbi.nlm.nih.gov/27807593

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Characteristics of Spontaneous Activity in the Bladder Trigone

Autor: Pravina M. Patel, Changhao Wu, Guiping Sui, Alexander Roosen, Rasheda A. Chowdhury, Christopher H. Fry

Publikováno v: European Urology. 56:346-354

Background During bladder filling, the trigone contracts help keep the ureteral orifices open and the bladder neck shut. The trigone generates spontaneous activity as well as responding to neuromuscular transmitters, but the relationship between thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104df9de9c13737ea5eba574fe8a0783
https://doi.org/10.1016/j.eururo.2008.06.048

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Remodeling of Gap Junctional Channel Function in Epicardial Border Zone of Healing Canine Infarcts

Autor: Wajid Hussain, Jian-An Yao, Nicholas S. Peters, Penelope A. Boyden, Pravina M. Patel, Andrew L. Wit

Publikováno v: Circulation Research. 92:437-443

The epicardial border zone (EBZ) of canine infarcts has increased anisotropy because of transverse conduction slowing. It remains unknown whether changes in gap junctional conductance (G j ) accompany the increased anisotropy. Ventricular cell pairs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499d50fba425a4f923648977b1048154
https://doi.org/10.1161/01.res.0000059301.81035.06

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Architectural correlates of myocardial conduction: changes to the topography of cellular coupling, intracellular conductance, and action potential propagation with hypertrophy in Guinea-pig ventricular myocardium

Autor: Pravina M. Patel, Christopher H. Fry, Nicholas S. Peters, Rita I. Jabr, Rosaire Gray, Paramdeep S. Dhillon, Emmanuel Dupont

Publikováno v: Circulation. Arrhythmia and electrophysiology. 7(6)

Background— We tested the hypothesis that alterations to action potential conduction velocity (CV) and conduction anisotropy in left ventricular hypertrophy are associated with topographical changes to gap-junction coupling and intracellular conduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41af1e3932da75ad0878c73a9e8f1b6a
https://pubmed.ncbi.nlm.nih.gov/25313260

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Relationship Between Connexin Expression and Gap-Junction Resistivity in Human Atrial Myocardium

Autor: Pravina M. Patel, Alex R. Shipolini, Rosaire Gray, Joshua Vecht, Nicholas S. Peters, Aziz Ul-Hassan Momin, Paramdeep S. Dhillon, Christopher H. Fry, Rita I. Jabr, Rasheda A. Chowdhury

Background— The relative roles of the gap-junctional proteins connexin40 (Cx40) and connexin43 (Cx43) in determining human atrial myocardial resistivity is unknown. In addressing the hypothesis that changing relative expression of Cx40 and Cx43 und

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620750587f915e03eb77bdeb820536c2
https://surrey.eprints-hosting.org/806787/

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Altering Ventricular Activation Remodels Gap Junction Distribution in Canine Heart

Autor: Nicholas S. Peters, Catherine T. Sheehan, Alexei Shvilkin, Prapa Kanagaratnam, Pravina M. Patel, Peter Danilo, Wen Xiong, Alexei N. Plotnikov, Michael R. Rosen

Publikováno v: Journal of Cardiovascular Electrophysiology. 12:570-577

Gap Junctional Remodeling in Paced Ventricle.Introduction: Prolonged arrhythmic or paced ventricular activation causes persistent changes in myocardial conduction and repolarization that may result from altered electrotonic current flow, for which ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81de714d4658212c13c30004b8fa10b
https://doi.org/10.1046/j.1540-8167.2001.00570.x

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Suburothelial myofibroblasts in the human overactive bladder and the effect of botulinum neurotoxin type A treatment

Autor: Sebastian Brandner, Alexander Roosen, Apostolos Apostolidis, Shahid Khan, Thomas M. Kessler, Sohier Elneil, Prokar Dasgupta, Vinay Kalsi, Pravina M. Patel, Rasheda A. Chowdhury, Christopher H. Fry, Soumendra N. Datta, Clare J. Fowler, Jalesh N. Panicker

Publikováno v: European Urology; Vol 55

Background An increasing body of evidence suggests a possible role of suburothelial myofibroblasts (MFs) in bladder mechanosensation and in the pathophysiology of detrusor overactivity (DO). Objective To determine whether markers of MFs, including ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f9741b73b7337ad7e2c66361493619

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Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro

Autor: Kenneth T. MacLeod, Pravina M. Patel, Hilmar Spohr, Charles Coutelle, Nina D. Ullrich, Yu-Ling Ma, Nicholas S. Peters, Yvonne Kienast, Michael Themis, Oleg Tolmachov

Publikováno v: BMC Cardiovascular Disorders
BMC Cardiovascular Disorders, Vol 6, Iss 1, p 25 (2006)

Background Organ transplantation is presently often the only available option to repair a damaged heart. As heart donors are scarce, engineering of cardiac grafts from autologous skeletal myoblasts is a promising novel therapeutic strategy. The funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8a8e4472632ac6c879ea15137be5e0
https://doi.org/10.1186/1471-2261-6-25

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