Epigenetic Silencing of RIPK3 in Hepatocytes Prevents MLKL-mediated Necroptosis From Contributing to Liver Pathologies

Autor: Simon P. Preston, Michael D. Stutz, Cody C. Allison, Ueli Nachbur, Quentin Gouil, Bang Manh Tran, Valerie Duvivier, Philip Arandjelovic, James P. Cooney, Liana Mackiewicz, Yanxiang Meng, Jan Schaefer, Stefanie M. Bader, Hongke Peng, Zina Valaydon, Pravin Rajasekaran, Charlie Jennison, Sash Lopaticki, Ann Farrell, Marno Ryan, Jess Howell, Catherine Croagh, Denuja Karunakaran, Carole Schuster-Klein, James M. Murphy, Theodora Fifis, Christopher Christophi, Elizabeth Vincan, Marnie E. Blewitt, Alexander Thompson, Justin A. Boddey, Marcel Doerflinger, Marc Pellegrini

Publikováno v: Gastroenterology. 163(6)

Necroptosis is a highly inflammatory mode of cell death that has been implicated in causing hepatic injury including steatohepatitis/ nonalcoholic steatohepatitis (NASH); however, the evidence supporting these claims has been controversial. A compreh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a48aac57c10be5bd2a7390df7ce977
https://pubmed.ncbi.nlm.nih.gov/36155192

Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection

Autor: Justin A Boddey, Marc Pellegrini, Annie S. P. Yang, Pravin Rajasekaran, Sash Lopaticki, Lisa J Ioannidis, Liana Mackiewicz, Gregor Ebert, Cody C. Allison, Ryan W.J. Steel, Matthew T. O'Neill, Marcel Doerflinger, Philip Arandjelovic, Sara M. Erickson, John Silke

Publikováno v: Cell Reports. 30:4343-4354.e4

Plasmodium sporozoites infect the liver and develop into exoerythrocytic merozoites that initiate blood-stage disease. The hepatocyte molecular pathways that permit or abrogate parasite replication and merozoite formation have not been thoroughly exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda5331a5a6030a7262a643bc73143e4
https://doi.org/10.1016/j.celrep.2020.03.032

Novel technique to determine the pK

Autor: James A, Angus, Pravin, Rajasekaran, Christine E, Wright

Publikováno v: European journal of pharmacology. 800

Analytical pharmacology draws heavily on the concept of equilibrium of agonist and silent antagonist concentrations competing at a specific receptor site. This condition breaks down in nerve transmission when transmitter release is inhibited by preju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::628172a09277f481184757b585f3397a
https://pubmed.ncbi.nlm.nih.gov/28219708

Plasmepsin V, a Secret Weapon Against Malaria

Autor: Kym N Lowes, Lea Barfod, Danushka S. Marapana, Brad E. Sleebs, Michelle Gazdik, Alan F. Cowman, Anthony N. Hodder, Pravin Rajasekaran, Sash Lopaticki, Brian J. Smith, Lars Hviid, Matthew T. O'Neill, Justin A Boddey, Svenja Günther, Philip J. Shaw, Lachlan Whitehead

Publikováno v: PLoS Biology, Vol 12, Iss 7, p e1001897 (2014)
PLoS Biology
Sleebs, B E, Lopaticki, S, Marapana, D S, O'Neill, M T, Rajasekaran, P, Gazdik, M, Günther, S, Whitehead, L W, Lowes, K N, Barfod, L, Hviid, L, Shaw, P J, Hodder, A N, Smith, B J, Cowman, A F & Boddey, J A 2014, ' Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites ', P L o S Biology, vol. 12, no. 7, pp. e1001897 . https://doi.org/10.1371/journal.pbio.1001897

A small molecule inhibitor of the malarial protease Plasmepsin V impairs protein export and cellular remodeling, reducing parasite survival in human erythrocytes.
The malaria parasite Plasmodium falciparum exports several hundred proteins into t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4646b08351d39719e939023940da062
https://doi.org/10.1371/journal.pbio.1001897