Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Pravin L. Kotian"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1940-1954 (2024)
Herein, we report a pair of regioselective N1- and N2-alkylations of a versatile indazole, methyl 5-bromo-1H-indazole-3-carboxylate (6) and the use of density functional theory (DFT) to evaluate their mechanisms. Over thirty N1- and N2-alkylated prod
Externí odkaz:
https://doaj.org/article/47de7d2fc3b043318b89dac856cc1901
Autor:
Pravin L. Kotian, Minwan Wu, Ajit Ghosh, Kevin J. Polach, Yahya El-Kattan, V. Satish Kumar, Tsu-Hsing Lin, Xiaogang Cheng, Shanta Bantia, Krishnan Raman, Pooran Chand, Yarlagadda S. Babu
Publikováno v:
Nucleosides, nucleotidesnucleic acids.
As a part of our ongoing discovery efforts exploring azasugar as agents for treating various unmet medical needs, we prepared analogs of azasugar as potential anti-hepatitis C virus (HCV) agents. Herein we describe the synthesis of novel 2'β-C-Me 9-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d665e858083ddafce01c2fe5c3366f
https://pubmed.ncbi.nlm.nih.gov/36354089
https://pubmed.ncbi.nlm.nih.gov/36354089
Autor:
Satish Vadlakonda, Jason Williams, Chintareddy Venkat R, Saritha Muppa, Kevin J Polach, Minwan Wu, Pravin L. Kotian, Zhang Weihe, Debra Kellogg-Yelder, Ramanda Chambers-Wilson, Xilin Chen, Lu Peng-Cheng, Raman Krishnan, Cynthia Parker, Yarlagadda S. Babu, Luis Juarez
Publikováno v:
Journal of Medicinal Chemistry. 64:12453-12468
Hereditary angioedema (HAE) is a rare and potentially life-threatening disease that affects an estimated 1 in 50 000 individuals worldwide. Until recently, prophylactic HAE treatment options were limited to injectables, a burdensome administration ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f84a0eb062ec2ea1f9855a4a4f9008c
https://doi.org/10.1021/acs.jmedchem.1c00511
https://doi.org/10.1021/acs.jmedchem.1c00511
Autor:
Yarlagadda S. Babu, Cynthia Parker, Raman Krishnan, Pravin L. Kotian, Saritha Muppa, Qingde Liu, Fugang Zhu, Xilin Chen, Xiaogang Cheng
Publikováno v:
Blood. 136:32-32
INTRODUCTION: Complement factor D is a serine protease that specifically catalyzes the cleavage of factor B [bound to C3(H2O) or C3b], its only natural substrate, to Ba and Bb. Factor D has the lowest concentration in plasma among all the complement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a78978978a65621c49ba55c3c0728481
https://doi.org/10.1182/blood-2020-133921
https://doi.org/10.1182/blood-2020-133921
Autor:
William P. Sheridan, Brian R. Taubenheim, Pravin L. Kotian, Dena M. Minning, Y.S. Babu, Donald F. Smee, Justin G. Julander, John D. Morrey, Shanta Bantia
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:6607-6614
No effective antiviral therapies are currently available to treat disease after infection with yellow fever virus (YFV). A Syrian golden hamster model of yellow fever (YF) was used to characterize the effect of treatment with BCX4430, a novel adenosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::961ad009f00efd19a41112fd036950b6
https://doi.org/10.1128/aac.03368-14
https://doi.org/10.1128/aac.03368-14
Autor:
Brett P. Eaton, Shanta Bantia, Shelley P. Honnold, Gianluca Pegoraro, Rekha G. Panchal, Nicole L. Garza, Travis K. Warren, Sina Bavari, Brian R. Taubenheim, William P. Sheridan, Jay Wells, Lian Dong, Pravin L. Kotian, Kelly S. Stuthman, Xilin Chen, Sean A. Van Tongeren, Y.S. Babu, Dena M. Minning, Cary Retterer, Lisa S. Welch
Publikováno v:
Nature
A broad-spectrum antiviral small molecule is reported to act as an inhibitor of viral polymerase activity and is shown to be effective in protecting non-human primates from lethal filovirus infection when administered after exposure. Supplementary in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22ee30eec1bfc646ed2a5e4d14995a9
http://europepmc.org/articles/PMC7095208
http://europepmc.org/articles/PMC7095208
Autor:
Raman Krishnan, Surendra K. Saini, Pooran Chand, Y. Sudhakar Babu, Scott R. Rowland, Shane Arnold, Yahya El-Kattan, Shanta Bantia, Pravin L. Kotian, Ramanda Upshaw
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:3934-3958
Factor VIIa (FVIIa), a serine protease enzyme, coupled with tissue factor (TF) plays an important role in a number of thrombosis-related disorders. Inhibition of TF x FVIIa occurs early in the coagulation cascade and might provide some safety advanta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e386f63754ff57584d80e442bafb2a54
https://doi.org/10.1016/j.bmc.2009.04.013
https://doi.org/10.1016/j.bmc.2009.04.013
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 63:689-697
Factor VIIa (FVIIa) is a trypsin-like serine protease in the coagulation cascade. Its complex with tissue factor (TF) triggers the extrinsic pathway of the coagulation cascade, generating a blood clot. Research programs at several centers now recogni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3c5f1beaba369f989663c7f29f2cf1
https://doi.org/10.1107/s0907444907014187
https://doi.org/10.1107/s0907444907014187
Autor:
Minwan Wu, Yarlagadda S. Babu, Shanta Bantia, Ajit Ghosh, Yahya El-Kattan, V. Satish Kumar, Tsu-Hsing Lin, Pooran Chand, Pravin L. Kotian, Xiaogang Cheng
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 25:121-140
The introduction of versatile functional groups, allyl and ester, at the C-1 position of the acyclic chain in acyclic adenine nucleosides was achieved for the first time directly by alkylation of adenine and N6-protected adenine. Thus, the C-1′-sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1f979c882b44ca7b98843590fe4b87
https://doi.org/10.1080/15257770500446816
https://doi.org/10.1080/15257770500446816
Autor:
Hans Prydz, Pravin L. Kotian, C. Shane Arnold, Shanta Bantia, Cynthia Parker, Ramanda Upshaw, Pooran Chand, Y. Sudhakar Babu
Publikováno v:
Thrombosis Research. 117:343-349
Tissue factor (TF) is a transmembrane glycoprotein that binds its zymogen cofactor, Factor VIIa (FVIIa) on the cell surface. Together (TF/FVIIa) they activate Factor X (FX) and Factor IX (FIX) and start the extrinsic pathway of blood coagulation. As
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68eb6cbb4650586797e205d06a5e0dbc
https://doi.org/10.1016/j.thromres.2005.03.015
https://doi.org/10.1016/j.thromres.2005.03.015