Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Pravin K Wagley"'
Autor:
Angelina June, Weronika Matysik, Maria Marlicz, Emily Zucker, Pravin K Wagley, Chia-Yi Kuan, Jennifer Burnsed
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0295860 (2024)
ObjectiveTo examine acute seizure activity and neuronal damage in a neonatal mouse model of inflammation-sensitized hypoxic-ischemic (IS-HI) brain injury utilizing continuous electroencephalography (cEEG) and neurohistology.MethodsNeonatal mice were
Externí odkaz:
https://doaj.org/article/1baaf379e04e4e5090c6b6b6f1ebef02
Autor:
Jeremy A. Thompson, Raquel M. Miralles, Eric R. Wengert, Pravin K. Wagley, Wenxi Yu, Ian C. Wenker, Manoj K. Patel
Publikováno v:
Epilepsia Open, Vol 7, Iss 2, Pp 280-292 (2022)
Abstract Objective SCN8A epileptic encephalopathy is caused predominantly by de novo gain‐of‐function mutations in the voltage‐gated sodium channel Nav1.6. The disorder is characterized by early onset of seizures and developmental delay. Most p
Externí odkaz:
https://doaj.org/article/d2052a1ccd2c4120a7aa09064b084006
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2022)
Sudden unexpected death in epilepsy (SUDEP) accounts for the deaths of 8–17% of patients with epilepsy. Although the mechanisms of SUDEP are unknown, one proposed mechanism is abnormal control of the heart by the autonomic nervous system (ANS). Our
Externí odkaz:
https://doaj.org/article/22f3b9dcbd084c6986ced33c5065ce89
Autor:
Eric R. Wengert, Ian C. Wenker, Elizabeth L. Wagner, Pravin K. Wagley, Ronald P. Gaykema, Jung-Bum Shin, Manoj K. Patel
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death amongst patients whose seizures are not adequately controlled by current therapies. Patients with SCN8A encephalopathy have an elevated risk for SUDEP. While transgenic mouse m
Externí odkaz:
https://doaj.org/article/c4a1dcfd7e464abf8d51bcd2c1132236
Autor:
Denise K. Grosenbaugh, Suchitra Joshi, Mark P. Fitzgerald, Kevin S. Lee, Pravin K. Wagley, Alexander F. Koeppel, Stephen D. Turner, Michael J. McConnell, Howard P. Goodkin
Publikováno v:
Neurobiology of Disease, Vol 140, Iss , Pp 104836- (2020)
Children with malformations of cortical development (MCD) are at risk for epilepsy, developmental delays, behavioral disorders, and intellectual disabilities. For a subset of these children, antiseizure medications or epilepsy surgery may result in s
Externí odkaz:
https://doaj.org/article/8894f587e3bb4dd4925e35408cf23754
Autor:
Pravin K. Wagley, Manoj K. Patel, Jeremy A. Thompson, Wenxi Yu, Ian C. Wenker, Raquel M Miralles, Eric R. Wengert
Publikováno v:
Epilepsia Open. 7:280-292
Objective SCN8A epileptic encephalopathy is caused predominantly by de novo gain-of-function mutations in the voltage-gated-sodium channel Nav 1.6. The disorder is characterized by early onset of seizures and developmental delay. Most patients with S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac97a412538a1a2538b0b25c5dc9980
https://doi.org/10.1002/epi4.12564
https://doi.org/10.1002/epi4.12564
Autor:
Eric R. Wengert, Manoj K. Patel, Jeremy A. Thompson, Payal S. Panchal, Pravin K. Wagley, Raquel M. Miralles, Abrar Majidi Idrissi, Ian C. Wenker, Ronald P. Gaykema, Kyle C. A. Wedgwood, Samantha M. Strohm
Publikováno v:
The Journal of Neuroscience. 41:9257-9273
SCN8Aepileptic encephalopathy is a devastating epilepsy syndrome caused by mutantSCN8A, which encodes the voltage-gated sodium channel NaV1.6. To date, it is unclear if and how inhibitory interneurons, which express NaV1.6, influence disease patholog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ee380df2e06201f55f86827fd518ab2
https://doi.org/10.1523/jneurosci.0718-21.2021
https://doi.org/10.1523/jneurosci.0718-21.2021
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09ab5a94bdb6fa104535d72ccec325bf
https://doi.org/10.1096/fasebj.2022.36.s1.r2354
https://doi.org/10.1096/fasebj.2022.36.s1.r2354
Autor:
Eric R. Wengert, Manoj K. Patel, Anne Christiansen, Ian C. Wenker, Pravin K. Wagley, Nuha Reza, Gene Liau, Samantha M. Strohm, Ronald P. Gaykema
Publikováno v:
Brain research. 1775
Dravet Syndrome (DS) is a severe developmental and epileptic encephalopathy typically caused by loss-of-function de novo mutations in the SCN1A gene which encodes the voltage-gated sodium channel isoform NaV1.1. Decreased NaV1.1 expression results in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aca1cba7ecdfbda8882cb59f40f127e
https://pubmed.ncbi.nlm.nih.gov/34843701
https://pubmed.ncbi.nlm.nih.gov/34843701
Autor:
Miriam H. Meisler, Manoj K. Patel, Eric R. Wengert, Pravin K Wagley, Julie M. Jones, Bryan S. Barker, Kritika Bhatia, Marissa R Maniaci, Howard P. Goodkin, Jack M. Parent, Jacy L. Wagnon, Alexa Faulkner, Rosie K. A. Bunton-Stasyshyn
Publikováno v:
Brain. 142:362-375
De novo mutations of the sodium channel gene SCN8A result in an epileptic encephalopathy with refractory seizures, developmental delay, and elevated risk of sudden death. p.Arg1872Trp is a recurrent de novo SCN8A mutation reported in 14 unrelated ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a022cb41d121528c1528897c90cd55a
https://doi.org/10.1093/brain/awy324
https://doi.org/10.1093/brain/awy324