A common 'hot spot' confers hERG blockade activity to alpha-scorpion toxins affecting K+ channels

Autor: Praveen Nambaru, Steve Peigneur, Yousra Abdel-Mottaleb, P.E. Bougis, Jan Tytgat, Honoo Satake, Gerardo Corzo, Marie-France Martin-Eauclaire, Lourival D. Possani, Brigitte Céard

Publikováno v: Biochemical Pharmacology
Biochemical Pharmacology, Elsevier, 2008, 76 (6), pp.805-15. ⟨10.1016/j.bcp.2008.07.008⟩
Biochemical Pharmacology, 2008, 76 (6), pp.805-15. ⟨10.1016/j.bcp.2008.07.008⟩

International audience; While alpha-KTx peptides are generally known for their modulation of the Shaker-type and the Ca(2+)-activated potassium channels, gamma-KTxs are associated with hERG channels modulation. An exception to the rule is BmTx3 which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301a37a21e1612414be190ee7c07f26c
https://hal.archives-ouvertes.fr/hal-00396424