Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Praveen M. Varghese"'
Autor:
Yu-Hoi Kang, Praveen M. Varghese, Ahmad Al Aiyan, Kirsten Pondman, Uday Kishore, Robert B. Sim
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The classical pathway of the complement system is activated by the binding of C1q in the C1 complex to the target activator, including immune complexes. Factor H is regarded as the key downregulatory protein of the complement alternative pathway. How
Externí odkaz:
https://doaj.org/article/eaef8149bb46499e8a5a01fdce376f2a
Autor:
Nazar Beirag, Chandan Kumar, Taruna Madan, Mohamed H. Shamji, Roberta Bulla, Daniel Mitchell, Valarmathy Murugaiah, Martin Mayora Neto, Nigel Temperton, Susan Idicula-Thomas, Praveen M. Varghese, Uday Kishore
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Lung surfactant protein D (SP-D) and Dendritic cell-specific intercellular adhesion molecules-3 grabbing non-integrin (DC-SIGN) are pathogen recognising C-type lectin receptors. SP-D has a crucial immune function in detecting and clearing pulmonary p
Externí odkaz:
https://doaj.org/article/49771887372d47b4adea507ef18a207c
Complement Activation-Independent Attenuation of SARS-CoV-2 Infection by C1q and C4b-Binding Protein
Autor:
Nazar Beirag, Praveen M. Varghese, Martin Mayora Neto, Ahmad Al Aiyan, Haseeb A. Khan, Moneeb Qablan, Mohamed H. Shamji, Robert B. Sim, Nigel Temperton, Uday Kishore
Publikováno v:
Viruses, Vol 15, Iss 6, p 1269 (2023)
The complement system is a key component of the innate immune response to viruses and proinflammatory events. Exaggerated complement activation has been attributed to the induction of a cytokine storm in severe SARS-CoV-2 infection. However, there is
Externí odkaz:
https://doaj.org/article/98cc6f76dc6e4bdd8e9b27ee26553a0c
Autor:
Praveen M. Varghese, Shuvechha Mukherjee, Futwan A. Al-Mohanna, Souad M. Saleh, Fahad N. Almajhdi, Nazar Beirag, Saad H. Alkahtani, Reena Rajkumari, Beatrice Nal Rogier, Robert B. Sim, Susan Idicula-Thomas, Taruna Madan, Valarmathy Murugaiah, Uday Kishore
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The complement system is designed to recognise and eliminate invading pathogens via activation of classical, alternative and lectin pathways. Human properdin stabilises the alternative pathway C3 convertase, resulting in an amplification loop that le
Externí odkaz:
https://doaj.org/article/b389acf03e7945558cd931b8c8ff9fed
Autor:
Praveen M. Varghese, Valarmathy Murugaiah, Nazar Beirag, Nigel Temperton, Haseeb A. Khan, Salman H. Alrokayan, Mohammed N. Al-Ahdal, Beatrice Nal, Futwan A. Al-Mohanna, Robert B. Sim, Uday Kishore
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
C4b Binding Protein (C4BP) is a major fluid phase inhibitor of the classical and lectin pathways of the complement system. Complement inhibition is achieved by binding to and restricting the role of activated complement component C4b. C4BP functions
Externí odkaz:
https://doaj.org/article/6244d0b5bb80483e8c4651b6363063f7
Autor:
Alessandro Mangogna, Praveen M. Varghese, Chiara Agostinis, Salman H. Alrokayan, Haseeb A. Khan, Cordula M. Stover, Beatrice Belmonte, Anna Martorana, Giuseppe Ricci, Roberta Bulla, Uday Kishore
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
The complement system is readily triggered by the presence of damage-associated molecular patterns on the surface of tumor cells. The complement alternative pathway provides rapid amplification of the molecular stress signal, leading to complement ca
Externí odkaz:
https://doaj.org/article/e91fc30770264b8abd55fc85ea98cc91
Autor:
Valarmathy Murugaiah, Chiara Agostinis, Praveen M. Varghese, Beatrice Belmonte, Salvatore Vieni, Fanan A. Alaql, Salman H. Alrokayan, Haseeb A. Khan, Anuvinder Kaur, Terry Roberts, Taruna Madan, Roberta Bulla, Uday Kishore
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Human surfactant protein D (SP-D) belongs to the family of collectins that is composed of a characteristic amino-terminal collagenous region and a carboxy-terminal C-type lectin domain. Being present at the mucosal surfaces, SP-D acts as a potent inn
Externí odkaz:
https://doaj.org/article/e7a4cf46ac304622aec46bf9f5ca5cac
Autor:
Valarmathy Murugaiah, Praveen M. Varghese, Soad M. Saleh, Anthony G. Tsolaki, Salman H. Alrokayan, Haseeb A. Khan, Kate S. Collison, Robert B. Sim, Béatrice Nal, Futwan A. Al-Mohanna, Uday Kishore
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The complement system is an ancient innate immune defense mechanism that can recognize molecular patterns on the invading pathogens. Factor H, as an inhibitor of the alternative pathway, down-regulates complement activation on the host cell surface.
Externí odkaz:
https://doaj.org/article/0a82a81391d645008c3a4433be53c3e5
Autor:
Valarmathy Murugaiah, Praveen M. Varghese, Nazar Beirag, Syreeta De Cordova, Robert B. Sim, Uday Kishore
Publikováno v:
Viruses, Vol 13, Iss 5, p 824 (2021)
The complement system represents a crucial part of innate immunity. It contains a diverse range of soluble activators, membrane-bound receptors, and regulators. Its principal function is to eliminate pathogens via activation of three distinct pathway
Externí odkaz:
https://doaj.org/article/5e232fd0b548449ab0810e7652ad0552
Autor:
Mohammed N. Al-Ahdal, Valarmathy Murugaiah, Praveen M. Varghese, Suhair M. Abozaid, Iram Saba, Ahmed Ali Al-Qahtani, Ansar A. Pathan, Lubna Kouser, Béatrice Nal, Uday Kishore
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Surfactant protein D (SP-D) is expressed in the mucosal secretion of the lung and contributes to the innate host defense against a variety of pathogens, including influenza A virus (IAV). SP-D can inhibit hemagglutination and infectivity of IAV, in a
Externí odkaz:
https://doaj.org/article/4ea77c720e15403cbdecca94b9969d20