Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Praveen Kusumanchi"'
Autor:
Themis Thoudam, Dipanjan Chanda, Jung Yi Lee, Min-Kyo Jung, Ibotombi Singh Sinam, Byung-Gyu Kim, Bo-Yoon Park, Woong Hee Kwon, Hyo-Jeong Kim, Myeongjin Kim, Chae Won Lim, Hoyul Lee, Yang Hoon Huh, Caroline A. Miller, Romil Saxena, Nicholas J. Skill, Nazmul Huda, Praveen Kusumanchi, Jing Ma, Zhihong Yang, Min-Ji Kim, Ji Young Mun, Robert A. Harris, Jae-Han Jeon, Suthat Liangpunsakul, In-Kyu Lee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Ca2+ overload-induced mitochondrial dysfunction is considered a contributing factor alcohol-associated liver disease pathogenesis. Here the authors report that PDK4 promotes Ca2 + -channelling complex formation at the endoplasmic reticulum-mitochondr
Externí odkaz:
https://doaj.org/article/ca818281f2e2456cb8d5bb15f28a64a9
Autor:
Yan Wang, Matthew Hamang, Alexander Culver, Huaizhou Jiang, Jennifer Yanum, Veronica Garcia, Joonyong Lee, Emily White, Praveen Kusumanchi, Naga Chalasani, Suthat Liangpunsakul, Benjamin C. Yaden, Guoli Dai
Publikováno v:
Hepatology Communications, Vol 6, Iss 10, Pp 2812-2826 (2022)
Abstract The role of activin B, a transforming growth factor β (TGFβ) superfamily cytokine, in liver health and disease is largely unknown. We aimed to investigate whether activin B modulates liver fibrogenesis. Liver and serum activin B, along wit
Externí odkaz:
https://doaj.org/article/1c9c2fe02fc048d98c59f9dc5a348679
Autor:
Zhihong Yang, Sen Han, Ting Zhang, Praveen Kusumanchi, Nazmul Huda, Kelsey Tyler, Kristina Chandler, Nicholas J. Skill, Wanzhu Tu, Mu Shan, Yanchao Jiang, Jessica L. Maiers, Kristina Perez, Jing Ma, Suthat Liangpunsakul
Publikováno v:
Hepatology Communications, Vol 6, Iss 6, Pp 1361-1372 (2022)
Alcohol‐associated liver disease is the leading cause of chronic liver disease. We hypothesized that the expression of specific coding genes is critical for the progression of alcoholic cirrhosis (AC) from compensated to decompensated states. For t
Externí odkaz:
https://doaj.org/article/6b64cc5a5b9e485a875a720857f2dbf0
Autor:
Jing Ma, Adrien Guillot, Zhihong Yang, Bryan Mackowiak, Seonghwan Hwang, Ogyi Park, Brandon J. Peiffer, Ali Reza Ahmadi, Luma Melo, Praveen Kusumanchi, Nazmul Huda, Romil Saxena, Yong He, Yukun Guan, Dechun Feng, Pau Sancho-Bru, Mengwei Zang, Andrew MacGregor Cameron, Ramon Bataller, Frank Tacke, Zhaoli Sun, Suthat Liangpunsakul, Bin Gao
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 14 (2022)
Intrahepatic neutrophil infiltration has been implicated in severe alcoholic hepatitis (SAH) pathogenesis; however, the mechanism underlying neutrophil-induced injury in SAH remains obscure. This translational study aims to describe the patterns of i
Externí odkaz:
https://doaj.org/article/1d54fb8fcbe94219bd2bea490035c8c2
Autor:
Sen Han, Ting Zhang, Praveen Kusumanchi, Nazmul Huda, Yanchao Jiang, Zhihong Yang, Suthat Liangpunsakul
Publikováno v:
Clinical and Molecular Hepatology, Vol 26, Iss 4, Pp 705-714 (2020)
Long non-coding RNAs (lncRNAs), a class of transcribed RNA molecules with the lengths exceeding 200 nucleotides, are not translated into protein. They can modulate protein-coding genes by controlling transcriptional and posttranscriptional processes.
Externí odkaz:
https://doaj.org/article/71212707b675468e92305ad4ddfe61f3
Autor:
Zhihong Yang, Rana V. Smalling, Yi Huang, Yanchao Jiang, Praveen Kusumanchi, Will Bogaert, Li Wang, Don A. Delker, Nicholas J. Skill, Sen Han, Ting Zhang, Jing Ma, Nazmul Huda, Suthat Liangpunsakul
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
Alcohol-associated liver disease (ALD) represents a spectrum of histopathological changes, including alcoholic steatosis, steatohepatitis, and cirrhosis. One of the early responses to excessive alcohol consumption is lipid accumulation in the hepatoc
Externí odkaz:
https://doaj.org/article/d5708828b4b84004958f756a2788b968
Autor:
Tianhao Zhou, Konstantina Kyritsi, Nan Wu, Heather Francis, Zhihong Yang, Lixian Chen, April O'Brien, Lindsey Kennedy, Ludovica Ceci, Vik Meadows, Praveen Kusumanchi, Chaodong Wu, Leonardo Baiocchi, Nicholas J. Skill, Romil Saxena, Amelia Sybenga, Linglin Xie, Suthat Liangpunsakul, Fanyin Meng, Gianfranco Alpini, Shannon Glaser
Publikováno v:
EBioMedicine, Vol 48, Iss , Pp 130-142 (2019)
Background: Cholangiocytes are the target cells of cholangiopathies including primary sclerosing cholangitis (PSC). Vimentin is an intermediate filament protein that has been found in various types of mesenchymal cells. The aim of this study is to ev
Externí odkaz:
https://doaj.org/article/606ab22e62a04d15a60b567e6cc3dc44
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
MicroRNAs are small non-coding RNAs that range in length from 18 to 24 nucleotides. As one of the most extensively studied microRNAs, microRNA-21 (miR-21) is highly expressed in many mammalian cell types. It regulates multiple biological functions su
Externí odkaz:
https://doaj.org/article/756307ce1fc044c9a329f8ddb3d80aa1
Autor:
Kristin Hollister, Praveen Kusumanchi, Ruth Ann Ross, Kristina Chandler, AdePeju Oshodi, Laura Heathers, Sean Teagarden, Li Wang, Alexander L. Dent, Suthat Liangpunsakul
Publikováno v:
Liver Research, Vol 2, Iss 1, Pp 52-59 (2018)
Background: Excessive drinkers (ED) and patients with alcoholic liver disease (ALD) are several times more susceptible to bacterial and viral infections and have a decrease in antibody responses to vaccinations. Follicular helper T (TFH) cells are es
Externí odkaz:
https://doaj.org/article/4c1c3d4badf94876a7624f72505c2918
Publikováno v:
Biomedicines, Vol 8, Iss 3, p 50 (2020)
Once ingested, most of the alcohol is metabolized in the liver by alcohol dehydrogenase to acetaldehyde. Two additional pathways of acetaldehyde generation are by microsomal ethanol oxidizing system (cytochrome P450 2E1) and catalase. Acetaldehyde ca
Externí odkaz:
https://doaj.org/article/85ff4cad13e04d79bb89d4e83f86ad55