Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Praveen Kokkonda"'
Autor:
Liam Hudson, Jeremy W. Mason, Matthias V. Westphal, Matthieu J. R. Richter, Jonathan R. Thielman, Bruce K. Hua, Christopher J. Gerry, Guoqin Xia, Heather L. Osswald, John M. Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I. C. Tresco, Shuang Liu, Andrew G. Reidenbach, Katherine S. Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M. Gampe, Nichola J. Smith, James E. Bradner, Connor W. Coley, Paul A. Clemons, Bruno Melillo, C. Suk-Yee Hon, Johannes Ottl, Christoph E. Dumelin, Jonas V. Schaefer, Ann Marie E. Faust, Frédéric Berst, Stuart L. Schreiber, Frédéric J. Zécri, Karin Briner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Diversity-oriented synthesis (DOS) is a powerful strategy to prepare molecules with underrepresented features in commercial screening collections, resulting in the elucidation of novel biological mechanisms. In parallel to the development of
Externí odkaz:
https://doaj.org/article/36c9d05209eb47b1b03cc9fce00df87d
Autor:
Liam Hudson, Jeremy W. Mason, Matthias V. Westphal, Matthieu J. R. Richter, Jonathan R. Thielman, Bruce K. Hua, Christopher J. Gerry, Guoqin Xia, Heather L. Osswald, John M. Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I. C. Tresco, Shuang Liu, Andrew G. Reidenbach, Katherine S. Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M. Gampe, Nichola J. Smith, James E. Bradner, Connor W. Coley, Paul A. Clemons, Bruno Melillo, C. Suk-Yee Hon, Johannes Ottl, Christoph E. Dumelin, Jonas V. Schaefer, Ann Marie E. Faust, Frédéric Berst, Stuart L. Schreiber, Frédéric J. Zécri, Karin Briner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/d2f9e92baa034e31a3064fe3179e5c22
Autor:
Vedagopuram Sreekanth, Qingxuan Zhou, Praveen Kokkonda, Heysol C. Bermudez-Cabrera, Donghyun Lim, Benjamin K. Law, Benjamin R. Holmes, Santosh K. Chaudhary, Rajaiah Pergu, Brittany S. Leger, James A. Walker, David K. Gifford, Richard I. Sherwood, Amit Choudhary
Publikováno v:
ACS Central Science, Vol 6, Iss 12, Pp 2228-2237 (2020)
Externí odkaz:
https://doaj.org/article/f59a8cf4db8b44faa234b0cf6a54c506
Autor:
Donghyun Lim, Qingxuan Zhou, Kurt J. Cox, Benjamin K. Law, Miseon Lee, Praveen Kokkonda, Vedagopuram Sreekanth, Rajaiah Pergu, Santosh K. Chaudhary, Soumyashree A. Gangopadhyay, Basudeb Maji, Sophia Lai, Yuka Amako, David B. Thompson, Hari K. K. Subramanian, Michael F. Mesleh, Vlado Dančík, Paul A. Clemons, Bridget K. Wagner, Christina M. Woo, George M. Church, Amit Choudhary
Publikováno v:
Nat Cell Biol
The need to control the activity and fidelity of CRISPR-associated nucleases has resulted in a demand for inhibitory anti-CRISPR molecules. The small-molecule inhibitor discovery platforms available at present are not generalizable to multiple nuclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0fc6b03b4a9c93d1ffd988021f853ba
https://doi.org/10.1038/s41556-022-01005-8
https://doi.org/10.1038/s41556-022-01005-8
Autor:
Praveen Kokkonda, Arghya Deb
Publikováno v:
Handbook of CH-Functionalization. :1-33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::659caf2d4c00f21e18f4afdceba46433
https://doi.org/10.1002/9783527834242.chf0231
https://doi.org/10.1002/9783527834242.chf0231
Autor:
Christopher J. Arp, Martin Reynders, Vedagopuram Sreekanth, Praveen Kokkonda, Michele Pagano, Amit Choudhary, Dirk Trauner
Immunomodulatory drugs (IMiDs), which include thalidomide and its derivatives, have emerged as the standard of care against multiple myeloma. They function as molecular glues that bind to the E3 ligase cereblon (CRBN) and induce protein interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00a6b9505b399fcc3f7f1a3671a39a14
https://doi.org/10.1101/2023.04.09.536172
https://doi.org/10.1101/2023.04.09.536172
Autor:
Liam Hudson, Jeremy W. Mason, Matthias V. Westphal, Matthieu J. R. Richter, Jonathan R. Thielman, Bruce K. Hua, Christopher J. Gerry, Guoqin Xia, Heather L. Osswald, John M. Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I. C. Tresco, Shuang Liu, Andrew G. Reidenbach, Katherine S. Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M. Gampe, Nichola J. Smith, James E. Bradner, Connor W. Coley, Paul A. Clemons, Bruno Melillo, C. Suk-Yee Hon, Johannes Ottl, Christoph E. Dumelin, Jonas V. Schaefer, Ann Marie E. Faust, Frédéric Berst, Stuart L. Schreiber, Frédéric J. Zécri, Karin Briner
Diversity-oriented synthesis (DOS)is a powerful strategy to prepare molecules with underrepresented features in commercial screening collections, resulting in the elucidation of novel biological mechanisms. In parallel to the development of DOS, DNA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea89009e90b9f024b527255fb7155d39
https://doi.org/10.1101/2022.10.16.512431
https://doi.org/10.1101/2022.10.16.512431
Autor:
Jonnell Candice Small, Rohit N. Kulkarni, Basudeb Maji, Miseon Lee, Stephen J. Lippard, Debasish Manna, Jacob M. Goldberg, Sevim Kahraman, Praveen Kokkonda, Ruth M. Elgamal, Amedeo Vetere, Bridget K. Wagner, Amit Choudhary
Publikováno v:
Journal of the American Chemical Society
The loss of insulin-producing β-cells is the central pathological event in type 1 and 2 diabetes, which has led to efforts to identify molecules to promote β-cell proliferation, protection, and imaging. However, the lack of β-cell specificity of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67c20500e2dfa85118cdda3f5fdcccd
https://doi.org/10.1021/jacs.0c00099
https://doi.org/10.1021/jacs.0c00099
Autor:
Max Jan, David R. Liu, Arghya Deb, Vedagopuram Sreekanth, Praveen Kokkonda, Veronika Shoba, Santosh K. Chaudhary, Benjamin L. Ebert, Jaron A. M. Mercer, Praveen K. Tiwari, Amit Choudhary, Sophia Lai, Tuan M. Nguyen
Proteolysis Targeting Chimeras (PROTACs), a class of heterobifunctional molecules that recruit target proteins to E3 ligases, have gained traction for targeted protein degradation. However, pomalidomide, a widely used E3 ligase recruiter in PROTACs,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af392a53b6a8e1f2ea031a468ca70edc
https://doi.org/10.1101/2021.11.18.468552
https://doi.org/10.1101/2021.11.18.468552
Autor:
Praveen Kokkonda, Rodrigo B. Andrade
Publikováno v:
Organic Letters. 21:9594-9597
Herein, we report the first asymmetric total synthesis of aspidospermatan indole alkaloid (+)-epi-condyfoline (1) in 15 steps from commercially available 2-methylindole-3-carboxaldehyde. Key steps include (1) our domino Michael/Mannich annulation met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e00f9fe607029d17869652226c77eacc
https://doi.org/10.1021/acs.orglett.9b03762
https://doi.org/10.1021/acs.orglett.9b03762