Zobrazeno 1 - 10
of 337
pro vyhledávání: '"Praveen, Anand"'
Autor:
Gordon Sloan, Philippe Donatien, Rosario Privitera, Pallai Shillo, Sharon Caunt, Dinesh Selvarajah, Praveen Anand, Solomon Tesfaye
Publikováno v:
Frontiers in Pain Research, Vol 5 (2024)
BackgroundIdentifying distinct mechanisms and biomarkers for painful diabetic peripheral neuropathy (DPN) is required for advancing the treatment of this major global unmet clinical need. We previously provided evidence in calf skin biopsies that dis
Externí odkaz:
https://doaj.org/article/cdd9e02ff619458699301c72fbbce9e1
Autor:
A. J. Venkatakrishnan, Praveen Anand, Patrick J. Lenehan, Pritha Ghosh, Rohit Suratekar, Eli Silvert, Colin Pawlowski, Abhishek Siroha, Dibyendu Roy Chowdhury, John C. O’Horo, Joseph D. Yao, Bobbi S. Pritt, Andrew P. Norgan, Ryan T. Hurt, Andrew D. Badley, John Halamka, Venky Soundararajan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The emergence of highly transmissible SARS-CoV-2 variants and vaccine breakthrough infections globally mandated the characterization of the immuno-evasive features of SARS-CoV-2. Here, we systematically analyzed 2.13 million SARS-CoV-2 genom
Externí odkaz:
https://doaj.org/article/fba33ff5aa224b2f947ad65933a846dd
Autor:
Praveen Anand, Patrick J. Lenehan, Michiel Niesen, Unice Yoo, Dhruti Patwardhan, Marcelo Montorzi, A. J. Venkatakrishnan, Venky Soundararajan
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-8 (2022)
Abstract Acute cardiac injury has been observed in a subset of COVID-19 patients, but the molecular basis for this clinical phenotype is unknown. It has been hypothesized that molecular mimicry may play a role in triggering an autoimmune inflammatory
Externí odkaz:
https://doaj.org/article/418d444ed33943be9dcd88ee418c74b9
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16340 (2023)
Terpenes in Cannabis sativa exert analgesic effects, but the mechanisms are uncertain. We examined the effects of 10 terpenes on capsaicin responses in an established model of neuronal hypersensitivity. Adult rat DRG neurons cultured with neurotrophi
Externí odkaz:
https://doaj.org/article/b7be239a800d402fa65393937fc7e8b3
Autor:
Rohit Suratekar, Pritha Ghosh, Michiel J M Niesen, Gregory Donadio, Praveen Anand, Venky Soundararajan, A J Venkatakrishnan
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 2, Pp 1-10 (2022)
Abstract The highly contagious Delta variant of SARS‐CoV‐2 has become a prevalent strain globally and poses a public health challenge around the world. While there has been extensive focus on understanding the amino acid mutations in the Delta va
Externí odkaz:
https://doaj.org/article/2cc1e88e04c54521bcb418b729fd04e2
Autor:
Praveen Anand, Rosario Privitera, Philippe Donatien, Hassan Fadavi, Solomon Tesfaye, Vassiliki Bravis, V. Peter Misra
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
IntroductionCurrent oral treatments for pain in diabetic peripheral neuropathy (DPN) do not affect the progression of DPN i.e., “disease modification.” We assessed whether Capsaicin 8% patch treatment can provide pain relief and also restore nerv
Externí odkaz:
https://doaj.org/article/de942a7d156443aa88b9dc6998ec0439
Autor:
Pallai Shillo, Yiangos Yiangou, Philippe Donatien, Marni Greig, Dinesh Selvarajah, Iain D. Wilkinson, Praveen Anand, Solomon Tesfaye
Publikováno v:
Frontiers in Pain Research, Vol 2 (2021)
Painful diabetic peripheral neuropathy can be intractable with a major impact, yet the underlying pain mechanisms remain uncertain. A range of neuronal and vascular biomarkers was investigated in painful diabetic peripheral neuropathy (painful-DPN) a
Externí odkaz:
https://doaj.org/article/9cd47bec165d41d88d07d8724f042f33
Autor:
A. J. Venkatakrishnan, Praveen Anand, Patrick J. Lenehan, Rohit Suratekar, Bharathwaj Raghunathan, Michiel J. M. Niesen, Venky Soundararajan
Publikováno v:
Vaccines, Vol 10, Iss 9, p 1509 (2022)
The emergence of a heavily mutated SARS-CoV-2 variant (Omicron; Pango lineage B.1.1.529 and BA sublineages) and its rapid spread to over 75 countries raised a global public health alarm. Characterizing the mutational profile of Omicron is necessary t
Externí odkaz:
https://doaj.org/article/01f279759ae34afabfeab79abb059894
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Introduction: Neuropathic pain associated with Non-freezing Cold Injury (NFCI) is a major burden to military service personnel. A key feature of NFCI is reduction of the intra-epidermal nerve fibre density in skin biopsies, in keeping with painful ne
Externí odkaz:
https://doaj.org/article/347cef428b3141a0856faa62ffca191f
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1008925 (2021)
Deep neural networks have demonstrated improved performance at predicting the sequence specificities of DNA- and RNA-binding proteins compared to previous methods that rely on k-mers and position weight matrices. To gain insights into why a DNN makes
Externí odkaz:
https://doaj.org/article/bf744ece26b94f47afe4a8430eaa5919