Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Pratyusha Mandal"'
Autor:
Kate E Mastraccio, Celeste Huaman, Si'Ana A Coggins, Caitlyn Clouse, Madeline Rader, Lianying Yan, Pratyusha Mandal, Imran Hussain, Anwar E Ahmed, Trung Ho, Austin Feasley, Bang K Vu, Ina L Smith, Wanda Markotter, Dawn L Weir, Eric D Laing, Christopher C Broder, Brian C Schaefer
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 10, Pp n/a-n/a (2023)
Abstract Infections with rabies virus (RABV) and related lyssaviruses are uniformly fatal once virus accesses the central nervous system (CNS) and causes disease signs. Current immunotherapies are thus focused on the early, pre‐symptomatic stage of
Externí odkaz:
https://doaj.org/article/f2f7561c73df4203a58b8d3978a4070c
Autor:
Edward S Mocarski, Pratyusha Mandal
Publikováno v:
PLoS Biology, Vol 19, Iss 8, p e3001371 (2021)
In this issue of PLOS Biology, Zhang and colleagues unveil a complex midgestational death during embryogenesis of mice harboring caspase-8 cleavage-resistant receptor-interacting protein (RIP) kinase (RIPK)1. Tumor necrosis factor (TNF) receptor (TNF
Externí odkaz:
https://doaj.org/article/d38a86b8f72749e19121331d88c2b774
Autor:
Pratyusha Mandal, John D Lyons, Eileen M Burd, Michael Koval, Edward S Mocarski, Craig M Coopersmith
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0246270 (2021)
During infectious disease, pathogen load drives inflammation and immune response that together contribute to tissue injury often resulting in organ dysfunction. Pulmonary failure in SARS-CoV2-infected hospitalized COVID-19 patients is one such promin
Externí odkaz:
https://doaj.org/article/a29f93cb0fe84b6992d31c454a7c8bf4
Autor:
Eui Ho Kim, Matthew C Woodruff, Lilit Grigoryan, Barbara Maier, Song Hee Lee, Pratyusha Mandal, Mario Cortese, Muktha S Natrajan, Rajesh Ravindran, Huailiang Ma, Miriam Merad, Alexander D Gitlin, Edward S Mocarski, Joshy Jacob, Bali Pulendran
Publikováno v:
eLife, Vol 9 (2020)
The squalene-based oil-in-water emulsion (SE) vaccine adjuvant MF59 has been administered to more than 100 million people in more than 30 countries, in both seasonal and pandemic influenza vaccines. Despite its wide use and efficacy, its mechanisms o
Externí odkaz:
https://doaj.org/article/e62364c0766c48fdad9fa823a8b76041
Autor:
Pratyusha Mandal, Lynsey N. Nagrani, Liliana Hernandez, Anita Louise McCormick, Christopher P. Dillon, Heather S. Koehler, Linda Roback, Emad S. Alnemri, Douglas R. Green, Edward S. Mocarski
Publikováno v:
Viruses, Vol 13, Iss 9, p 1707 (2021)
Programmed cell death pathways eliminate infected cells and regulate infection-associated inflammation during pathogen invasion. Cytomegaloviruses encode several distinct suppressors that block intrinsic apoptosis, extrinsic apoptosis, and necroptosi
Externí odkaz:
https://doaj.org/article/f06cb379cd384a1fb21784dffe00b61d
Publikováno v:
Viruses, Vol 12, Iss 11, p 1221 (2020)
Cytomegaloviruses all encode the viral inhibitor of caspase-8-induced apoptosis (vICA). After binding to this initiator caspase, vICA blocks caspase-8 proteolytic activity and ability to activate caspase-3 and/or caspase-7. In this manner, vICA has l
Externí odkaz:
https://doaj.org/article/e695ceb84bd145d599beea730370c76f
Autor:
Pratyusha Mandal, Bridgette E Krueger, Darby Oldenburg, Katherine A Andry, R Suzanne Beard, Douglas W White, Erik S Barton
Publikováno v:
PLoS Pathogens, Vol 7, Iss 11, p e1002371 (2011)
The gammaherpesviruses, including Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), establish latency in memory B lymphocytes and promote lymphoproliferative disease in immunocompromised individuals. The precise immune mech
Externí odkaz:
https://doaj.org/article/94a2f1429edb4acbbeabbb15897745f7
Autor:
John D. Lyons, Pratyusha Mandal, Shunsuke Otani, Deena B. Chihade, Kristen F. Easley, David A. Swift, Eileen M. Burd, Zhe Liang, Michael Koval, Edward S. Mocarski, Craig M. Coopersmith
Publikováno v:
American journal of respiratory cell and molecular biology.
RIPK3 kinase activity triggers cell death via necroptosis, while scaffold function supports protein binding and cytokine production. To determine if RIPK3 kinase or scaffold domains mediate pathology during Pseudomonas aeruginosa infection, control m
Autor:
Edward S. Mocarski, Heather S Koehler, Emad S. Alnemri, Linda Roback, Pratyusha Mandal, Anita Louise McCormick, Liliana Hernandez, Christopher P. Dillon, Douglas R. Green, Lynsey N Nagrani
Publikováno v:
Viruses, Vol 13, Iss 1707, p 1707 (2021)
Viruses
Volume 13
Issue 9
Viruses
Volume 13
Issue 9
Programmed cell death pathways eliminate infected cells and regulate infection-associated inflammation during pathogen invasion. Cytomegaloviruses encode several distinct suppressors that block intrinsic apoptosis, extrinsic apoptosis, and necroptosi
Autor:
Edward S. Mocarski, Pratyusha Mandal
This volume provides a comprehensive review of programmed cell death pathways and their fundamental role in antiviral host defense. The book deep-dives into the molecular functions and regulation of necroptosis and discusses how viruses induce and ma