Unique Transcription Factor Functions Regulate Epigenetic and Transcriptional Dynamics During Cardiac Reprogramming

Autor: Ivey Kn, Ethan Radzinsky, Pratt Kjb, Gifford Ca, Mohamed Tma, Amelia Schricker, Katherine S. Pollard, Nicole Stone, Reuben Thomas, Kaitlen Samse-Knapp, Srivastava D, Pengzhi Yu

SUMMARYDirect lineage conversion, whereby a somatic cell assumes a new cellular identity, can be driven by ectopic expression of combinations of lineage-enriched transcription factors. To determine the molecular mechanisms by which expression of Gata

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f10fe13a2a51002894dce6615a35fa3

Spatial Coding Dysfunction and Network Instability in the Aging Medial Entorhinal Cortex.

Autor: Herber CS; Department of Neurobiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, 94305, USA., Pratt KJB; Department of Anatomy, University of California San Francisco, 513 Parnassus Avenue, Box 0452, San Francisco, CA, 94143, USA.; These authors contributed equally., Shea JM; Department of Anatomy, University of California San Francisco, 513 Parnassus Avenue, Box 0452, San Francisco, CA, 94143, USA.; These authors contributed equally., Villeda SA; Department of Anatomy, University of California San Francisco, 513 Parnassus Avenue, Box 0452, San Francisco, CA, 94143, USA.; Bakar Aging Research Institute, San Francisco, CA, 94143, USA., Giocomo LM; Department of Neurobiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, 94305, USA.; Lead contact.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 17. Date of Electronic Publication: 2024 Apr 17.

Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function.

Autor: Pratt KJB, Shea JM, Remesal-Gomez L, Bieri G, Smith LK, Couthouis J, Chen CP, Roy IJ, Gontier G, Villeda SA

Publikováno v: Cell reports [Cell Rep] 2023 Feb 28; Vol. 42 (2), pp. 111926. Date of Electronic Publication: 2023 Jan 30.

Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits.

Autor: Yu D; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California at San Francisco, San Francisco, CA 94143, USA.; Weill Institute for Neuroscience, University of California at San Francisco, San Francisco, CA 94143, USA., Li T; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California at San Francisco, San Francisco, CA 94143, USA.; Weill Institute for Neuroscience, University of California at San Francisco, San Francisco, CA 94143, USA., Delpech JC; Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Zhu B; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California at San Francisco, San Francisco, CA 94143, USA.; Weill Institute for Neuroscience, University of California at San Francisco, San Francisco, CA 94143, USA., Kishore P; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California at San Francisco, San Francisco, CA 94143, USA., Koshi T; Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Luo R; Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Pratt KJB; Department of Anatomy, University of California at San Francisco, San Francisco CA 94143, USA.; Developmental and Stem Cell Biology Graduate Program, University of California at San Francisco, San Francisco, CA 94143, USA., Popova G; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California at San Francisco, San Francisco, CA 94143, USA.; Department of Anatomy, University of California at San Francisco, San Francisco CA 94143, USA.; Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94143, USA., Nowakowski TJ; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California at San Francisco, San Francisco, CA 94143, USA.; Weill Institute for Neuroscience, University of California at San Francisco, San Francisco, CA 94143, USA.; Department of Anatomy, University of California at San Francisco, San Francisco CA 94143, USA.; Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94143, USA., Villeda SA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California at San Francisco, San Francisco, CA 94143, USA.; Department of Anatomy, University of California at San Francisco, San Francisco CA 94143, USA.; Developmental and Stem Cell Biology Graduate Program, University of California at San Francisco, San Francisco, CA 94143, USA.; Department of Physical Therapy and Rehabilitation Science, University of California at San Francisco, San Francisco, CA 94143, USA., Piao X; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California at San Francisco, San Francisco, CA 94143, USA.; Weill Institute for Neuroscience, University of California at San Francisco, San Francisco, CA 94143, USA.; Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Neonatology, Department of Pediatrics, University of California at San Francisco, San Francisco, CA 94158, USA.; Newborn Brain Research Institute, University of California at San Francisco, San Francisco, CA 94158, USA.

Publikováno v: Science advances [Sci Adv] 2022 May 06; Vol. 8 (18), pp. eabm2545. Date of Electronic Publication: 2022 May 06.