IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function

Autor: Ridgley, LA, Anderson, AE, Maney, NJ, Naamane, N, Skelton, AJ, Lawson, CA, Emery, P, Isaacs, JD, Carmody, RJ, Pratt, AG

Objective: We have previously shown that increased circulating interleukin-6 (IL-6) results in enhanced CD4+ T cell signaling via signal transduction and activator of transcription-3 (STAT3) in early rheumatoid arthritis (RA). We tested the hypothesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::36e62da67f3c409e5e586482e6b88193

The clinical utility of a rule for predicting rheumatoid arthritis in patients with early undifferentiated arthritis: Comment on the article by van der Helm-van Mil et al.

Autor: Pratt AG, Isaacs JD, Wilson G

Publikováno v: Arthritis & Rheumatism; Mar2009, Vol. 60 Issue 3, p905-905, 1p

Scientific Business Abstracts.

Autor: Cooles F; Newcastle University, Newcastle Upon Tyne, UK., Vidal-Pedrola G; Newcastle University, Newcastle Upon Tyne, UK., Naamane N; Newcastle University, Newcastle Upon Tyne, UK., Pratt A; Newcastle University, Newcastle Upon Tyne, UK., Barron-Millar B; Newcastle University, Newcastle Upon Tyne, UK., Anderson A; Newcastle University, Newcastle Upon Tyne, UK., Hilkens C; Newcastle University, Newcastle Upon Tyne, UK., Casement J; Newcastle University, Newcastle Upon Tyne, UK., Bondet V; Pasteur Institue, Paris, France., Duffy D; Pasteur Institue, Paris, France., Zhang F; Harvard University, Boston, MA, USA., Shukla R; Newcastle University, Newcastle Upon Tyne, UK., Isaacs J; Newcastle University, Newcastle Upon Tyne, UK., Little M; The Fairfax Lab, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Payne M; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Coupe N; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Fairfax B; The Fairfax Lab, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Taylor CA; The Fairfax Lab, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Mackay S; The Fairfax Lab, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Milotay G; The Fairfax Lab, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Bos S; Newcastle University Translational and Clinical Research Institute, Newcastle Upon Tyne, UK.; Institute of Transplantation, Newcastle upon Tyne Hospitals NHS Trust, Newcastle Upon Tyne, UK., Hunter B; Flow Cytometry Core and Innovation, Methodology and Application Research Theme, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, UK., Mcdonald D; Flow Cytometry Core and Innovation, Methodology and Application Research Theme, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, UK., Merces G; Image Analysis Unit, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK., Sheldon G; Medical School, Newcastle University, Newcastle Upon Tyne, UK., Pradère P; Department of Respiratory Diseases, Hôpital Marie Lannelongue, Groupe Hospitalier Paris Saint Joseph and Paris Saclay University, Paris, France., Majo J; Department of Cellular Pathology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK., Pulle J; Department of Cellular Pathology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK., Vanstapel A; Department of Pathology, University Hospitals Leuven, Leuven, Belgium., Vanaudenaerde BM; Department of CHROMETA, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium., Vos R; Department of CHROMETA, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium.; Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium., Filby AJ; Flow Cytometry Core and Innovation, Methodology and Application Research Theme, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, UK., Fisher AJ; Newcastle University Translational and Clinical Research Institute, Newcastle Upon Tyne, UK.; Institute of Transplantation, Newcastle upon Tyne Hospitals NHS Trust, Newcastle Upon Tyne, UK., Collier J; Newcastle University, Newcastle upon Tyne, UK.; Montreal Neurological Institute, McGill University, Montreal, Canada., Lambton J; Newcastle University, Newcastle upon Tyne, UK., Suomi F; University of Helsinki, Helsinki, Finland., Prigent M; Université Paris-Saclay, CEA, CNRS, Gif-sur-Yvette, France.; INSERM U1280, Gif-sur-Yvette, France., Guissart C; University of Montpellier and University Hospital, Montpellier, France., Erskine D; Newcastle University, Newcastle upon Tyne, UK., Rozanska A; Newcastle University, Newcastle upon Tyne, UK., Mccorvie T; Newcastle University, Newcastle upon Tyne, UK., Trimouille A; Groupe Hospitalier Pellegrin, CHU Bordeaux, Bordeaux, France., Imam A; Leeds Teaching Hospitals NHS Trust, Leeds, UK., Hobson E; Leeds Teaching Hospitals NHS Trust, Leeds, UK., Mccullagh H; Leeds Teaching Hospitals NHS Trust, Leeds, UK., Frengen E; Oslo University Hospital and University of Oslo, Oslo, Norway., Misceo D; Oslo University Hospital and University of Oslo, Oslo, Norway., Bjerre A; Oslo University Hospital and University of Oslo, Oslo, Norway., Smeland M; University Hospital of North Norway, Tromsø, Norway., Klingenberg C; University Hospital of North Norway, Tromsø, Norway., Alkuraya F; King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia., Mcfarland R; Newcastle University, Newcastle upon Tyne, UK.; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Alston C; Newcastle University, Newcastle upon Tyne, UK.; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Yue W; Newcastle University, Newcastle upon Tyne, UK., Legouis R; Université Paris-Saclay, CEA, CNRS, Gif-sur-Yvette, France.; INSERM U1280, Gif-sur-Yvette, France., Koenig M; University of Montpellier and University Hospital, Montpellier, France., Lako M; Newcastle University, Newcastle upon Tyne, UK., Mcwilliams T; University of Helsinki, Helsinki, Finland., Oláhová M; Newcastle University, Newcastle upon Tyne, UK.; Northumbria University, Newcastle upon Tyne, UK., Taylor R; Newcastle University, Newcastle upon Tyne, UK.; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Newman W; University of Manchester, Manchester, UK., Harkness R; University of Manchester, Manchester, UK., McDermott J; University of Manchester, Manchester, UK., Metcalfe K; Manchester Centre for Genomic Medicine, Manchester, UK., Khan N; Manchester Centre for Genomic Medicine, Manchester, UK., Macken W; UCL Queen Square Institute of Neurology, London, UK., Pitceathly R; UCL Queen Square Institute of Neurology, London, UK., Record C; UCL Queen Square Institute of Neurology, London, UK., Maroofian R; UCL Queen Square Institute of Neurology, London, UK., Sabir A; West Midlands Clinical Genetics Unit, Birmingham, UK., Santra S; West Midlands Clinical Genetics Unit, Birmingham, UK., Urquhart J; University of Manchester, Manchester, UK., Demain L; University of Manchester, Manchester, UK., Byers H; University of Manchester, Manchester, UK., Beaman G; University of Manchester, Manchester, UK., Yue W; Newcastle University, Newcastle, UK., Taylor R; Newcastle University, Newcastle, UK., Durmusalioglu E; Ege University, Izmir, Turkey., Atik T; Ege University, Izmir, Turkey., Isik E; Ege University, Izmir, Turkey., Cogulu O; Ege University, Izmir, Turkey., Reunert J; University of Münster, Münster, Germany., Marquardt T; University of Münster, Münster, Germany., Ryba L; Charles University, Prague, Czech Republic., Buchert-Lo R; University of Tübingen, Tübingen, Germany., Haack T; University of Tübingen, Tübingen, Germany., Lassuthova P; University of Tübingen, Tübingen, Germany., Polavarapu K; Children's Hospital Eastern Ontario, Ottawa, Canada., Lochmuller H; Children's Hospital Eastern Ontario, Ottawa, Canada., Horvath R; University of Cambridge, Cambridge, UK., Jamieson P; Manchester Centre for Genomic Medicine, Manchester, UK., Reilly M; UCL Queen Square Institute of Neurology, London, UK., O'Keefe R; University of Manchester, Manchester, UK., Boggan R; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Ng YS; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Franklin I; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Alston C; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Blakely E; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Büchner B; Department of Neurology, Friedrich-Baur-Institut, University Hospital of the Ludwig-Maximilians-University (LMU Klinikum), Munich, Germany., Bugiardini E; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.; NHS Highly Specialised Service for Rare Mitochondrial Disorders, Queen Square Centre for Neuromuscular Diseases, The National Hospital for Neurology and Neurosurgery, London, UK., Colclough K; Exeter Genomics Laboratory, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK., Feeney C; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Hanna M; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.; NHS Highly Specialised Service for Rare Mitochondrial Disorders, Queen Square Centre for Neuromuscular Diseases, The National Hospital for Neurology and Neurosurgery, London, UK., Hattersley A; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK., Klopstock T; Department of Neurology, Friedrich-Baur-Institut, University Hospital of the Ludwig-Maximilians-University (LMU Klinikum), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Kornblum C; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Mancuso M; Department of Neurology, Neuromuscular Diseases Section, University Hospital Bonn, Bonn, Germany., Patel K; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK., Pitceathly R; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.; NHS Highly Specialised Service for Rare Mitochondrial Disorders, Queen Square Centre for Neuromuscular Diseases, The National Hospital for Neurology and Neurosurgery, London, UK., Pizzamiglio C; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.; NHS Highly Specialised Service for Rare Mitochondrial Disorders, Queen Square Centre for Neuromuscular Diseases, The National Hospital for Neurology and Neurosurgery, London, UK., Prokisch H; Department of Clinical and Experimental Medicine, Neurological Institute, University of Pisa, Pisa, Italy.; Institute of Human Genetics, School of Medicine, Technische Universität München, Munich, Germany., Schäfer J; Institute of Neurogenomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Schaefer A; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Shepherd M; Institute of Neurogenomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Thaele A; Department of Neurology, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Thomas R; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Turnbull D; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK., Gorman G; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Woodward C; NHS Highly Specialised Service for Rare Mitochondrial Disorders, Queen Square Centre for Neuromuscular Diseases, The National Hospital for Neurology and Neurosurgery, London, UK.; Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle, Germany., McFarland R; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Taylor R; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Cordell H; Neurogenetics Unit, The National Hospital for Neurology and Neurosurgery, London, UK., Pickett S; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Tsilifis C; Translational And Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Paediatric Immunology & HSCT, Great North Children's Hospital, Newcastle upon Tyne, UK., Pearce M; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Gennery A; Translational And Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Paediatric Immunology & HSCT, Great North Children's Hospital, Newcastle upon Tyne, UK., Daly A; Newcastle University, Newcastle Upon Tyne, UK., Darlay R, Zatorska M, Worthington S, Anstee Q, Cordell H, Reeves H; Newcastle University, Newcastle upon Tyne, UK.; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Nizami S; Newcastle University, Newcastle upon Tyne, UK., Mauricio-Muir J; Newcastle University, Newcastle upon Tyne, UK., McCain M; Newcastle University, Newcastle upon Tyne, UK., Singh R; Newcastle University, Newcastle upon Tyne, UK., Wordsworth J; Newcastle University, Newcastle upon Tyne, UK., Kadharusman M; Newcastle University, Newcastle upon Tyne, UK.; University of Indonesia, Jakarta, Indonesia., Watson R; Newcastle University, Newcastle upon Tyne, UK., Masson S; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., McPherson S; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Burt A; Newcastle University, Newcastle upon Tyne, UK., Tiniakos D; Newcastle University, Newcastle upon Tyne, UK.; National & Kapodistrian University of Athens, Athens, Greece., Littler P; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Nsengimana J; Newcastle University, Newcastle upon Tyne, UK., Zhang S; Newcastle University, Newcastle upon Tyne, UK., Mann D; Newcastle University, Newcastle upon Tyne, UK., Jamieson D; Newcastle University, Newcastle upon Tyne, UK., Leslie J; Newcastle University, Newcastle upon Tyne, UK., Shukla R; Northumbria University, Newcastle upon Tyne, UK., Wilson C; Newcastle University, Newcastle upon Tyne, UK.; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Betts J; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; University of Sheffield, Sheffield, UK.; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Croall I; University of Sheffield, Sheffield, UK., Hoggard N; University of Sheffield, Sheffield, UK.; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Bennett J; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.; Rheumatology, Freeman Hospital, The Newcastle upon Tyne Hospitals NHS Foundation Trust, UK., Naamane N; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Hollingsworth KG; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Pratt AG; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.; Rheumatology, Freeman Hospital, The Newcastle upon Tyne Hospitals NHS Foundation Trust, UK., Egail M; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Feeney C; Wellcome Centre for Mitochondrial Research, Newcastle University Translational and Clinical Research Institute, Newcastle University, UK., Di Leo V; Wellcome Centre for Mitochondrial Research, Newcastle University Translational and Clinical Research Institute, Newcastle University, UK., Taylor RW; Wellcome Centre for Mitochondrial Research, Newcastle University Translational and Clinical Research Institute, Newcastle University, UK.; Highly Specialised Mitochondrial Laboratory, The Newcastle upon Tyne Hospitals NHS Foundation Trust, UK., Dodds R; NIHR Newcastle Biomedical Research Centre, The Newcastle upon Tyne Hospitals NHS Foundation Trust, UK., Anderson AE; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Sayer AA; NIHR Newcastle Biomedical Research Centre, The Newcastle upon Tyne Hospitals NHS Foundation Trust, UK., Isaacs JD; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.; Rheumatology, Freeman Hospital, The Newcastle upon Tyne Hospitals NHS Foundation Trust, UK., McCracken C; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Condurache DG; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK., Szabo L; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK., Elghazaly H; Department of Medicine, Imperial College London and Imperial College NHS Trust, London, UK., Walter F; Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Meade A; Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Chakraverty R; Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Harvey N; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK., Manisty C; Institute of Cardiovascular Science, University College London, London, UK., Petersen S; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK., Neubauer S; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Raisi-Estabragh Z; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK., Allen L; Diabetes Research Group, Cardiff University, Cardiff, UK., Taylor P; Diabetes Research Group, Cardiff University, Cardiff, UK., Carlsson A; Lund University, Lund, Sweden., Hagopian W; Pacific Northwest Research Institute, Seattle, USA., Hedlund E; Lund University, Lund, Sweden., Hill A; Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK., Jones A; Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK.; Medical School, University of Exeter, Exeter, UK., Ludvigsson J; Linköping University, Linköping, Sweden., Onengut-Gumuscu S; Center for Public Health Genomics, University of Virginia, Charlottesville, USA., Redondo M; Texas Children's Hospital, Baylor College of Medicine, USA., Rich S; Center for Public Health Genomics, University of Virginia, Charlottesville, USA., Gillespie K; Diabetes and Metabolism Unit, University of Bristol, Bristol, UK., Dayan C; Diabetes Research Group, Cardiff University, Cardiff, UK., Oram R; Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK.; Medical School, University of Exeter, Exeter, UK., Resteu A; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Wonders K; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Schattenberg J; Department of Internal Medicine II, Saarland University Medical Center, Homburg, Germany., Straub B; Metabolic Liver Research Program, Department of Medicine, University Hospital Mainz, Mainz, Germany., Ekstedt M; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden., Berzigotti A; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Geier A; Department of Hepatology, University of Würzburg, Würzburg, Germany., Francque S; Department of Gastroenterology Hepatology, Antwerp University Hospital, Antwerp, Belgium.; Translational Sciences in Inflammation and Immunology, Laboratory of Experimental Medicine and Paediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium., Driessen A; Department of Pathology, Antwerp University Hospital, Antwerp University, Antwerp, Belgium., Boursier J; Service d'Hépato-Gastroentérologie, Centre Hospitalier Universitaire d'Angers, Angers, France.; Laboratoire HIFIH UPRES EA3859, Université d'Angers, Angers, France., Yki-Jarvinen H; University of Helsinki, Helsinki University Hospital, and Minerva Foundation Institute for Medical Research, Helsinki, Finland., Arola J; University of Helsinki, Helsinki University Hospital, and Minerva Foundation Institute for Medical Research, Helsinki, Finland., Aithal G; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK., Holleboom A; Department of Vascular Medicine, Amsterdam University Medical Centres, Amsterdam, The Netherlands., Verheij J; Department of Vascular Medicine, Amsterdam University Medical Centres, Amsterdam, The Netherlands., Yunis C; Pfizer Global Product Development, New York, USA., Trylesinski A; Advanz Pharmaceuticals, London, UK., Papatheodoridis G; Department of Gastroenterology, Medical School of National and Kapodistrian University of Athens School of Health Sciences, General Hospital of Athens 'Laiko', Athens, Greece., Petta S; Sezione di Gastroenterologia, Dipartimento Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza 'G. D'Alessandro', Università di Palermo, Palermo, Italy., Romero-Gomez M; UCM Digestive Diseases, Virgen del Rocio University Hospital, Instituto de Biomedicina de Sevilla, CIBEREHD, University of Seville, Seville, Spain., Bugianesi E; Division of Gastro-Hepatology, Department of Medical Sciences, City of Health and Science of Turin, University of Turin, Turin, Italy., Paradis V; Assistance Publique-Hôpitaux de Paris, Hôpital Beaujon, University Paris-Diderot, Paris, France., Ratziu V; Assistance Publique-Hôpitaux de Paris, Hôpital Beaujon, University Paris-Diderot, Paris, France., Tiniakos D; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Department of Pathology, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece and., Anstee Q; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Newcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Burton J; University of Glasgow, Glasgow, UK., Ciminata G; University of Glasgow, Glasgow, UK., Geue C; University of Glasgow, Glasgow, UK., Quinn T; University of Glasgow, Glasgow, UK., Glover E; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Morais M; Division of Cell Matrix Biology and Regenerative Medicine, University of Manchester, Manchester, UK., Reynolds G; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.; Centre for Immunology and Inflammatory Diseases, Mass General Research Institute, Harvard Medical School, Boston, USA., Denby L; Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh, UK., Ali S; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Lennon R; Division of Cell Matrix Biology and Regenerative Medicine, University of Manchester, Manchester, UK., Sheerin N; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Yang F; National Heart & Lung Institute, Imperial College London, London, UK., Zounemat-Kermani N; Department of Computing & Data Science Institute, National Heart & Lung Institute, Imperial College London, London, UK., Dixey P; National Heart & Lung Institute, Imperial College London, London, UK., Adcock IM; Department of Computing & Data Science Institute, National Heart & Lung Institute, Imperial College London, London, UK., Bloom CI; National Heart & Lung Institute, Imperial College London, London, UK., Chung KF; Department of Computing & Data Science Institute, National Heart & Lung Institute, Imperial College London, London, UK., Govaere O; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Hasoon M; Bioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Alexander L; SomaLogic, Inc., Boulder, USA., Cockell S; Bioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Tiniakos D; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Ekstedt M; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden., Schattenberg JM; I. Department of Medicine, University Hospital Mainz, Mainz, Germany., Boursier J; Hepatology Department, Angers University Hospital, Angers, France., Bugianesi E; Division of Gastro-Hepatology, Department of Medical Sciences, A.O. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy., Ratziu V; Assistance Publique-Hôpitaux de Paris, Hôpital Pitié Salpêtrière, Sorbonne University, ICAN (Institute of Cardiometabolism and Nutrition), Paris, France., Daly AK; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Anstee QM; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

Publikováno v: QJM : monthly journal of the Association of Physicians [QJM] 2024 Sep 19. Date of Electronic Publication: 2024 Sep 19.

Monitoring immunE DysregulAtion foLLowing Immune checkpOint-inhibitioN (MEDALLION): protocol for an observational cancer immunotherapy cohort study.

Autor: Gault A; Translational and Clinical Research Institute, The Medical School, Newcastle University, William Leech Building, Framlington Place, Newcastle upon Tyne, NE4 2HH, UK.; Northern Centre for Cancer Care, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Hogarth L; Northern Centre for Cancer Care, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Williams KC; Translational and Clinical Research Institute, The Medical School, Newcastle University, William Leech Building, Framlington Place, Newcastle upon Tyne, NE4 2HH, UK., Greystoke A; Northern Centre for Cancer Care, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Rajan N; Translational and Clinical Research Institute, The Medical School, Newcastle University, William Leech Building, Framlington Place, Newcastle upon Tyne, NE4 2HH, UK.; Department of Dermatology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Speight A; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Lamb CA; Translational and Clinical Research Institute, The Medical School, Newcastle University, William Leech Building, Framlington Place, Newcastle upon Tyne, NE4 2HH, UK.; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Bridgewood A; Northern Centre for Cancer Care, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Brown-Schofield LJ; Northern Centre for Cancer Care, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Rayner F; Translational and Clinical Research Institute, The Medical School, Newcastle University, William Leech Building, Framlington Place, Newcastle upon Tyne, NE4 2HH, UK.; Department of Rheumatology, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Isaacs JD; Translational and Clinical Research Institute, The Medical School, Newcastle University, William Leech Building, Framlington Place, Newcastle upon Tyne, NE4 2HH, UK.; Department of Rheumatology, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Nsengimana J; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Stewart CJ; Translational and Clinical Research Institute, The Medical School, Newcastle University, William Leech Building, Framlington Place, Newcastle upon Tyne, NE4 2HH, UK., Anderson AE; Translational and Clinical Research Institute, The Medical School, Newcastle University, William Leech Building, Framlington Place, Newcastle upon Tyne, NE4 2HH, UK., Plummer R; Translational and Clinical Research Institute, The Medical School, Newcastle University, William Leech Building, Framlington Place, Newcastle upon Tyne, NE4 2HH, UK.; Northern Centre for Cancer Care, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Pratt AG; Translational and Clinical Research Institute, The Medical School, Newcastle University, William Leech Building, Framlington Place, Newcastle upon Tyne, NE4 2HH, UK. arthur.pratt@newcastle.ac.uk.; Department of Rheumatology, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. arthur.pratt@newcastle.ac.uk.

Publikováno v: BMC cancer [BMC Cancer] 2024 Jun 14; Vol. 24 (1), pp. 733. Date of Electronic Publication: 2024 Jun 14.

Operational complexities in international clinical trials: a systematic review of challenges and proposed solutions.

Autor: Gumber L; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Northumbria Healthcare NHS Foundation Trust, Northumbria, UK., Agbeleye O; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Inskip A; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Fairbairn R; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Still M; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Ouma L; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Lozano-Kuehne J; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Bardgett M; Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK., Isaacs JD; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Musculoskeletal Unit, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle Upon Tyne, UK., Wason JM; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Craig D; NIHR Innovation Observatory, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Pratt AG; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK arthur.pratt@newcastle.ac.uk.; Musculoskeletal Unit, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle Upon Tyne, UK.

Publikováno v: BMJ open [BMJ Open] 2024 Apr 15; Vol. 14 (4), pp. e077132. Date of Electronic Publication: 2024 Apr 15.