First-in-Human Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Rapidly Developed SARS-CoV-2 Therapeutic Antibody, AOD01, in Healthy Adults.

Autor: Prativadibhayankaram VS; Experimental Drug Development Centre, A*STAR Research Entities (ARES), Singapore, Singapore., Lee LS; National Centre for Infectious Diseases, Tan Tock Seng Hospital, 16 Jalan Tan Tock Seng, Singapore, 308442, Singapore., Lye D; National Centre for Infectious Diseases, Tan Tock Seng Hospital, 16 Jalan Tan Tock Seng, Singapore, 308442, Singapore.; Yong Loo Lin School of Medicine, Singapore, Singapore.; Lee Kong Chian School of Medicine, Singapore, Singapore., Xiaoying X; National Centre for Infectious Diseases, Tan Tock Seng Hospital, 16 Jalan Tan Tock Seng, Singapore, 308442, Singapore., Nellore R; Experimental Drug Development Centre, A*STAR Research Entities (ARES), Singapore, Singapore., Pendharkar V; Experimental Drug Development Centre, A*STAR Research Entities (ARES), Singapore, Singapore., Hentze H; Experimental Drug Development Centre, A*STAR Research Entities (ARES), Singapore, Singapore., Guan S; Hummingbird Bioscience, Singapore, Singapore., Ayers BJ; Hummingbird Bioscience, Singapore, Singapore., Seah SGK; Biological Defence Programme, DSO National Laboratories, Singapore, Singapore., Chye H; Biological Defence Programme, DSO National Laboratories, Singapore, Singapore., Talib NSN; Institute of Molecular and Cell Biology (IMCB), A*STAR Research Entities (ARES), Singapore, Singapore., Kaliaperumal N; Institute of Molecular and Cell Biology (IMCB), A*STAR Research Entities (ARES), Singapore, Singapore., Ong WY; Institute of Molecular and Cell Biology (IMCB), A*STAR Research Entities (ARES), Singapore, Singapore., Wong ZX; Institute of Molecular and Cell Biology (IMCB), A*STAR Research Entities (ARES), Singapore, Singapore., Au VB; Institute of Molecular and Cell Biology (IMCB), A*STAR Research Entities (ARES), Singapore, Singapore., Alok A; Institute of Molecular and Cell Biology (IMCB), A*STAR Research Entities (ARES), Singapore, Singapore., Connolly JE; Institute of Molecular and Cell Biology (IMCB), A*STAR Research Entities (ARES), Singapore, Singapore.; Institute of Biomedical Studies, Baylor University, Waco, TX, USA., Boyd-Kirkup JD; Hummingbird Bioscience, Singapore, Singapore., Ingram PJ; Hummingbird Bioscience, Singapore, Singapore., Hanson BJ; Hummingbird Bioscience, Singapore, Singapore., Ethirajulu K; Experimental Drug Development Centre, A*STAR Research Entities (ARES), Singapore, Singapore., O'Connell D; Experimental Drug Development Centre, A*STAR Research Entities (ARES), Singapore, Singapore., Chan CEZ; National Centre for Infectious Diseases, Tan Tock Seng Hospital, 16 Jalan Tan Tock Seng, Singapore, 308442, Singapore. conrad_ez_chan@ncid.sg.; Biological Defence Programme, DSO National Laboratories, Singapore, Singapore. conrad_ez_chan@ncid.sg.

Publikováno v: Infectious diseases and therapy [Infect Dis Ther] 2022 Oct; Vol. 11 (5), pp. 1999-2015. Date of Electronic Publication: 2022 Sep 04.