Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis

Autor: Krishna C. Chinta, Md. Aejazur Rahman, Vikram Saini, Joel N. Glasgow, Vineel P. Reddy, Jeremie M. Lever, Shepherd Nhamoyebonde, Alasdair Leslie, Ryan M. Wells, Amie Traylor, Rajhmun Madansein, Gene P. Siegal, Veena B. Antony, Jessy Deshane, Gordon Wells, Kievershen Nargan, James F. George, Pratistadevi K. Ramdial, Anupam Agarwal, Adrie J.C. Steyn

Publikováno v: Cell Reports, Vol 25, Iss 7, Pp 1938-1952.e5 (2018)

Summary: Heme oxygenase-1 (HO-1) is a cytoprotective enzyme that controls inflammatory responses and redox homeostasis; however, its role during pulmonary tuberculosis (TB) remains unclear. Using freshly resected human TB lung tissue, we examined the

Externí odkaz: https://doaj.org/article/4c7da74431894b99aa2b05cd2ea1ba01

Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis

Autor: Rui Wang, Shannon L. Russell, Kievershen Nargan, Pratistadevi K. Ramdial, John H. Adamson, Adrie J. C. Steyn, Bridgette M. Cumming, Aejazur Rahman, Hayden T Pacl, Threnesan Naidoo, Kelvin W. Addicott

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Tuberculosis (TB) is responsible for millions of deaths each year and several billion people are latently infected with Mycobacterium tuberculosis (Mtb). Mtb modulates host factors, such as endogenous gaseous signalling molecules, to per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5ffb8f73d63d5b203fcfa9931e8d7cb
https://doi.org/10.1073/pnas.1919211117

Malignant and pre-malignant oesophageal pathology in a South African teaching hospital

Autor: Cris Mulder, Benn Sartorius, Emil Loots, Pratistadevi K. Ramdial, Damian L. Clarke

Publikováno v: Loots, E, Ramdial, P K, Sartorius, B, Mulder, C M & Clarke, D L 2018, ' Malignant and pre-malignant oesophageal pathology in a South African teaching hospital ', South African Journal of Surgery, vol. 56, no. 1, pp. 21-24 . https://doi.org/10.17159/2078-5151/2018/v56n1a2076
South African Journal of Surgery; Vol 55, No 4 (2017)
South African Journal of Surgery; Vol 56, No 1 (2018); 21-24
South African Journal of Surgery, Volume: 56, Issue: 1, Pages: 21-24, Published: MAR 2018
South African Journal of Surgery, Volume: 55, Issue: 4, Pages: 1-4, Published: NOV 2017
South African Journal of Surgery, 56(1), 21-24. South African Medical Association

Introduction: South Africa (SA) has one of the highest global incidences of squamous cell carcinoma of the oesophagus (SCC). A decreasing incidence of oesophageal SCC in SA has been suggested. The study aimed to assess whether the incidence of these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe22342c761acff2b83d327508eacc2
https://research.vumc.nl/en/publications/4592075e-7626-4736-95c9-8eaef4529b81

Vulval Tuberculosis: The Histomorphological Spectrum in Patients with HIV Co-Infection and AIDS

Autor: Pillay B, Nhlonzi Gb, Kievershen Nargan, Naidoo T, Kuppusamy Jb, Pratistadevi K. Ramdial, Steyn Ajc, Lumamba Kd

Publikováno v: Journal of AIDS & Clinical Research.

Objective: Vulval tuberculosis (TB) is reported rarely. The histomorphological spectrum and diagnostic mimicry thereof in patients with concomitant HIV infection/ AIDS is unreported to date. This study aimed to appraise the histopathologic spectrum o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd6407c1770541aae25b7fbb49509ba7
https://doi.org/10.4172/2155-6113.1000719

Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis

Autor: Krishna C. Chinta, Md. Aejazur Rahman, Vikram Saini, Joel N. Glasgow, Vineel P. Reddy, Jeremie M. Lever, Shepherd Nhamoyebonde, Alasdair Leslie, Ryan M. Wells, Amie Traylor, Rajhmun Madansein, Gene P. Siegal, Veena B. Antony, Jessy Deshane, Gordon Wells, Kievershen Nargan, James F. George, Pratistadevi K. Ramdial, Anupam Agarwal, Adrie J.C. Steyn

Publikováno v: Cell Reports
Cell Reports, Vol 25, Iss 7, Pp 1938-1952.e5 (2018)

Summary Heme oxygenase-1 (HO-1) is a cytoprotective enzyme that controls inflammatory responses and redox homeostasis; however, its role during pulmonary tuberculosis (TB) remains unclear. Using freshly resected human TB lung tissue, we examined the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6b76a46c4f81fc45825af01cca7c4c
https://doi.org/10.1016/j.celrep.2019.08.081