Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Pratima Deshpande"'
Autor:
Dhanalakshmi Sivanandhan, Santhosh Viswakarma, Rashmi Rekha Devi, Ramchandraiah Gosu, Tabassum Sahareen, Chandregowda Venkateshappa, Chandru Gajendran, Pratima Deshpande, Muralidhar Reddy, Sundarajan kannan, Prashanthi Daram, Pendyala Satya Kishore, Amir Siddiqui, Mohammed Zainuddin, Naveen Sadhu M, Sridharan Rajagopal, Rudresh G
Publikováno v:
Cancer Research. 81:1630-1630
Introduction: The PD-1/PD-L1 molecular pathway is one of the primary mechanisms of immune evasion deployed by cancer cells. Induction of PD-L1 expression on cancer cells is associated with inhibition of immune responses against cancer, thus favouring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c97fd18b3a293131f80ad1802f75d19
https://doi.org/10.1158/1538-7445.am2021-1630
https://doi.org/10.1158/1538-7445.am2021-1630
Publikováno v:
2017 International Conference on Energy, Communication, Data Analytics and Soft Computing (ICECDS).
Security in Embedded systems has become an important constraint in modern days. There are different cryptographic algorithms developed for providing data security. Among these Diffie-Hellman is the basic one. Diffie-Hellman Key Exchange method of cry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dd2534e53abe6ec66c1de8ced011ec2
https://doi.org/10.1109/icecds.2017.8389808
https://doi.org/10.1109/icecds.2017.8389808
Autor:
Sergey Pryshchep, Jörg J. Goronzy, Pratima Deshpande, Ines Colmegna, Vladimir M. Liarski, Karnail Singh, Cornelia M. Weyand
Publikováno v:
The Journal of Immunology. 183:8258-8267
Immune responses to citrullinated neoantigens and clinical efficacy of costimulation blockade indicate a general defect in maintaining T cell tolerance in rheumatoid arthritis (RA). To examine whether TCR threshold calibration contributes to disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64df61e8ae4bfa1b6fcd101e841be558
https://doi.org/10.4049/jimmunol.0901784
https://doi.org/10.4049/jimmunol.0901784
Autor:
Pratima Deshpande, Ravi K. Babu, Anu-Maarit Moilanen, Pekka Kallio, Mahaboobi Jaleel, Chandrasekhar Abbineni, Susanta Samajdar, Prashant Yallappa Vadnal, Murali Ramachandra
Publikováno v:
Cancer Research. 77:LB-113
Background: ODM-207 is a potent and selective BET inhibitor that is structurally unrelated to the benzodiazepine-based inhibitors including JQ1, I-BET762, and OTX015. Phase I clinical trials have now been initiated with this agent based on its potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed0ec518c253d4920c7c15c44f101484
https://doi.org/10.1158/1538-7445.am2017-lb-113
https://doi.org/10.1158/1538-7445.am2017-lb-113
Autor:
Mary M. Cavanagh, Karnail Singh, Sabine Le Saux, Pratima Deshpande, Cornelia M. Weyand, Jörg J. Goronzy
Regulation of the ERK pathway is intimately involved in determining whether TCR stimulation is productive or induces anergy. T cells from patients with rheumatoid arthritis (RA) have increased ERK responsiveness, which may be relevant for disease pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f829d2901699abae175f226ca9e9a66
https://europepmc.org/articles/PMC3574821/
https://europepmc.org/articles/PMC3574821/
Autor:
Mingcan Yu, Guangjin Li, Karnail Singh, Sergey Pryshchep, Mary M. Cavanagh, Pratima Deshpande, Cornelia M. Weyand, Jörg J. Goronzy
Publikováno v:
Proceedings of the National Academy of Sciences. 109
Autoantibodies to common autoantigens and neoantigens, such as IgG Fc and citrullinated peptides, are immunological hallmarks of rheumatoid arthritis (RA). We examined whether a failure in maintaining tolerance is mediated by defects in T-cell recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c834401fec61b84163eeb8f263b88344
https://doi.org/10.1073/pnas.1117640109
https://doi.org/10.1073/pnas.1117640109
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 178(11)
CD11c+ dendritic cells (DCs) are a prominent component of CNS infiltrates in mice with experimental autoimmune encephalomyelitis. However, their role in immunopathogenesis is controversial. In this study, we report that they originate from peripheral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fe65b7e841cd04098f279d91261930
https://pubmed.ncbi.nlm.nih.gov/17513712
https://pubmed.ncbi.nlm.nih.gov/17513712
Publikováno v:
Journal of neuroimmunology. 173(1-2)
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease of the central nervous system. IL-12p40 monokines play a critical role in the generation of EAE-inducing CD4+T cells. Here we show that IL-12 directly upregulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfba06b23f2610ef5d5cb4d8564c446a
https://pubmed.ncbi.nlm.nih.gov/16413063
https://pubmed.ncbi.nlm.nih.gov/16413063
Publikováno v:
The Journal of Immunology. 186:101.16-101.16
In animal models, lymphopenia and the associated function of homeostatic cytokines (HC) set the stage for autoimmunity. This model is relevant for rheumatoid arthritis (RA) which has defects in T cell homeostasis due to a failure in DNA repair and wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dce5b6ead85a2ace6db895783e88b560
https://doi.org/10.4049/jimmunol.186.supp.101.16
https://doi.org/10.4049/jimmunol.186.supp.101.16
Publikováno v:
The Journal of Immunology. 182:49.8-49.8
Immune responses to citrullinated neoantigens indicate a tolerance defect in rheumatoid arthritis (RA). We examined the hypothesis that abnormal TCR signaling in RA T cells lowers the activation threshold. T cells from 33 seropositive RA patients and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f8ce6346ed96726e868461cc76b3013
https://doi.org/10.4049/jimmunol.182.supp.49.8
https://doi.org/10.4049/jimmunol.182.supp.49.8