Výsledky vyhledávání - "Pratik S. Sachdeva"

Not optimal, just noisy: the geometry of correlated variability leads to highly suboptimal sensory coding

Autor: Jesse A. Livezey, Pratik S. Sachdeva, Maximilian E. Dougherty, Mathew T. Summers, Kristofer E. Bouchard

The brain represents the world through the activity of neural populations. Correlated variability across simultaneously recorded neurons (noise correlations) has been observed across cortical areas and experimental paradigms. Many studies have shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89b0df10894b88ca8ac8fbcc449637ef
https://doi.org/10.1101/2022.03.08.483488

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Heterogeneous Synaptic Weighting Improves Neural Coding in the Presence of Common Noise

Autor: Pratik S. Sachdeva, Michael R. DeWeese, Jesse A. Livezey

Publikováno v: Neural computation, vol 32, iss 7

Simultaneous recordings from the cortex have revealed that neural activity is highly variable, and that some variability is shared across neurons in a population. Further experimental work has demonstrated that the shared component of a neuronal popu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d893e42eff8c2b73e048cec97698c5de
https://escholarship.org/uc/item/4c03j1t8

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Accurate inference in parametric models reshapes neuroscientific interpretation and improves data-driven discovery

Autor: Kristofer E. Bouchard, Jesse A. Livezey, Pratik S. Sachdeva, Joshua D. Berke, Bon-Mi Gu, Maximilian E. Dougherty

A central goal of systems neuroscience is to understand the relationships amongst constituent units in neural populations and their modulation by external factors using high-dimensional and stochastic neural recordings. Statistical models, particular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8be3a2f188b9d32c7dfa2fb923ad2d6

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Sparse, Predictive, and Interpretable Functional Connectomics with UoI

Autor: Kristofer E. Bouchard, Sharmodeep Bhattacharyya, Pratik S. Sachdeva

Publikováno v: EMBC

Network formation from neural activity is a foundational problem in systems neuroscience. Functional networks, after downstream analysis, can provide key insights into the nature of neurobiological structure and computation. The validity of such insi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474c3bff1d890b1d850572ab93c716ca
https://pubmed.ncbi.nlm.nih.gov/31946284

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Improved inference in coupling, encoding, and decoding models and its consequence for neuroscientific interpretation

Autor: Pratik S. Sachdeva, Jesse A. Livezey, Maximilian E. Dougherty, Kristofer E. Bouchard, Bon-Mi Gu, Joshua D. Berke

Publikováno v: Journal of Neuroscience Methods. 358:109195

Background A central goal of systems neuroscience is to understand the relationships amongst constituent units in neural populations, and their modulation by external factors, using high-dimensional and stochastic neural recordings. Parametric statis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a9aca6a9a9d3b5fd2557bc44e39d6e
https://doi.org/10.1016/j.jneumeth.2021.109195

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On the stability of strange dwarf hybrid stars

Autor: Pratik S. Sachdeva, Steven P. Harris, Mark G. Alford

We investigate the stability of stars with a density discontinuity between a high-density core and a very low density mantle. Previous work on "strange dwarfs" suggested that such a discontinuity could stabilize stars that would have been classified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd88a60ec59546c8d63a578c5e7f8d5
http://arxiv.org/abs/1705.09880

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Anticancer activity of Noscapine, an opioid alkaloid in combination with Cisplatin in human non-small cell lung cancer

Autor: Tanise Jackson, Mahavir B. Chougule, Pratik S. Sachdeva, Apurva R. Patel, Mandip Singh

The purpose of this study was to examine the efficacy of Noscapine (Nos) and Cisplatin (Cis) combination treatment in vitro in A549 and H460 lung cancer cells, in vivo in murine xenograft model and to investigate the underlying mechanism. The combina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fcd4c81043f26cb7214a71589fee12d
https://europepmc.org/articles/PMC3094914/

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Enhanced Anticancer Activity of Gemcitabine in Combination with Noscapine via Antiangiogenic and Apoptotic Pathway against Non-Small Cell Lung Cancer

Autor: Apurva R. Patel, Tanise Jackson, Mandip Singh, Mahavir B. Chougule, Pratik S. Sachdeva

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27394 (2011)
PLoS ONE

Background The aim of this investigation was to evaluate the anticancer activity of Noscapine (Nos) and Gemcitabine (Gem) combination (NGC) against non-small cell lung cancer (NSCLC) and to elucidate the underlying mechanism of action. Methods Isobol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e28be501074f126e5c7ba7eb363476
https://doi.org/10.1371/journal.pone.0027394

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