Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Pratik Pal"'
Autor:
Dongwen Lv, Pratik Pal, Xingui Liu, Yannan Jia, Dinesh Thummuri, Peiyi Zhang, Wanyi Hu, Jing Pei, Qi Zhang, Shuo Zhou, Sajid Khan, Xuan Zhang, Nan Hua, Qingping Yang, Sebastian Arango, Weizhou Zhang, Digant Nayak, Shaun K. Olsen, Susan T. Weintraub, Robert Hromas, Marina Konopleva, Yaxia Yuan, Guangrong Zheng, Daohong Zhou
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Simultaneous targeting of BCL-xL and BCL-2 is an attractive approach for cancer treatment. Based on information gained by computational structure modelling, the authors develop a PROTAC that induces degradation of both BCL-xL and BCL-2 and effectivel
Externí odkaz:
https://doaj.org/article/38d97353bbbf41e4aa6eb4a5907c3bd4
Publikováno v:
ACS Omega, Vol 6, Iss 6, Pp 4355-4361 (2021)
Externí odkaz:
https://doaj.org/article/0b705f2beb374b8e8f2b40ba6561314e
Publikováno v:
Expert Opinion on Therapeutic Patents. 32:1003-1026
The anti-apoptotic BCL-2 family proteins, such as BCL-2, BCL-XL, and MCL-1, are excellent cancer therapeutic targets. The FDA approval of BCL-2 selective inhibitor venetoclax in 2016 validated the strategy of targeting these proteins with BH3 mimetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53edd63639bddc145c1add04c8922277
https://doi.org/10.1080/13543776.2022.2116311
https://doi.org/10.1080/13543776.2022.2116311
Publikováno v:
Organic & Biomolecular Chemistry. 20:2473-2499
Visible light-induced photoisomerization method of γ-(Z)-alkylidenebutenolides to their corresponding E-components is investigated and explored further for total synthesis of related natural products.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e66b4424b8bbe2e270ab2dc07423e8f
https://doi.org/10.1039/d2ob00166g
https://doi.org/10.1039/d2ob00166g
Autor:
Pratik Pal Bariha
Publikováno v:
Psychology and Education Journal. 58:5069-5074
The aim of this study is to achieve the understanding on the different types of loyalty programs and their impact on the customers buying decision, patterns, behavior and ultimately the impact of their retention towards the brand or product in a long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::add7f62b19a821d4572273027ba3d9b7
https://doi.org/10.17762/pae.v58i1.2012
https://doi.org/10.17762/pae.v58i1.2012
Autor:
Xuan Zhang, Shaun K. Olsen, Sebastian Arango, Sajid Khan, Yaxia Yuan, Digant Nayak, Xingui Liu, Weizhou Zhang, Wanyi Hu, Pratik Pal, Dongwen Lv, Guangrong Zheng, Qi Zhang, Jing Pei, Robert Hromas, Daohong Zhou, Qingping Yang, Susan T. Weintraub, Dinesh Thummuri, Marina Konopleva, Peiyi Zhang, Shuo Zhou, Nan Hua, Yannan Jia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
PROteolysis-TArgeting Chimeras (PROTACs) have emerged as an innovative drug development platform. However, most PROTACs have been generated empirically because many determinants of PROTAC specificity and activity remain elusive. Through computational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3513b71bfb490f894b81566dc45cf9
https://doi.org/10.1038/s41467-021-27210-x
https://doi.org/10.1038/s41467-021-27210-x
Autor:
Pratik, Pal, Dinesh, Thummuri, Dongwen, Lv, Xingui, Liu, Peiyi, Zhang, Wanyi, Hu, Saikat K, Poddar, Nan, Hua, Sajid, Khan, Yaxia, Yuan, Xuan, Zhang, Daohong, Zhou, Guangrong, Zheng
Publikováno v:
J Med Chem
BCL-X(L) and BCL-2 are important targets for cancer treatment. BCL-X(L) specific PROTACs have been developed to circumvent the on-target platelet toxicity associated with BCL-X(L) inhibition. However, they have minimal effects on cancer cells that ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::372aad213ee3d30ca6d2fd1ff1dadb60
https://pubmed.ncbi.nlm.nih.gov/34533954
https://pubmed.ncbi.nlm.nih.gov/34533954
Publikováno v:
ACS Omega
Carboxyethyl hydroxychromans (CEHCs) are natural metabolites of vitamin E (VE). Their urinary levels can serve as useful biomarkers for the nutritional assessment of VE. Moreover, specific biological activities of CEHCs deserve further investigation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::68dc9742186dce69949b5581e80e614c
https://pubmed.ncbi.nlm.nih.gov/33623846
https://pubmed.ncbi.nlm.nih.gov/33623846
Autor:
Pratik Pal, Samik Nanda
Publikováno v:
Organic Letters. 19:1164-1167
A short and flexible asymmetric synthesis of ramariolides A and C was accomplished. A bimetallic catalytic system consisting of Pd-Cu-mediated cascade cyclization, unprecedented Z-E isomerization by a Ru-based metathesis catalyst, and late-stage ster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4fcf07a7f564e8b2989438aea3f05a3
https://doi.org/10.1021/acs.orglett.7b00202
https://doi.org/10.1021/acs.orglett.7b00202
Publikováno v:
Organicbiomolecular chemistry. 17(14)
Asymmetric total synthesis of the naturally occurring cryptoconcatone I, which possesses a γ-Z-butenolide framework, is described here for the first time. Asymmetric propargylation, E-selective cross metathesis, and regioselective reductive epoxide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0d608f9b7dfe0ea5fbe99017510660
https://pubmed.ncbi.nlm.nih.gov/30899921
https://pubmed.ncbi.nlm.nih.gov/30899921