Zobrazeno 1 - 3
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pro vyhledávání: '"Pratigya Tripathi"'
Autor:
Ankit Ganeshpurkar, Ravi Singh, Pratigya Tripathi, Qadir Alam, Sairam Krishnamurthy, Ashok Kumar, Sushil K. Singh
Publikováno v:
Ibrain, Vol 9, Iss 1, Pp 13-31 (2023)
Abstract Alzheimer's disease is a neurodegenerative disease responsible for dementia and other neuropsychiatric symptoms. In the present study, compounds 30 and 33, developed earlier in our laboratory as selective butyrylcholinesterase inhibitors, we
Externí odkaz:
https://doaj.org/article/811f52c173e047ea9528e3b68d2aad6f
Publikováno v:
International journal of biological macromolecules. 228
Glucocerebrosidase (GCase), a GBA1 gene-encoded lysosomal enzyme, is a risk factor for Parkinson's disease (PD). Chaperones that increase GCase activity can potentially be disease-modifying agents in PD. To date, none of the registered treatments has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c5c1d9526d3536dada2c26610b3cd9
https://pubmed.ncbi.nlm.nih.gov/36565835
https://pubmed.ncbi.nlm.nih.gov/36565835
Publikováno v:
Bioorganic Chemistry. 126:105871
Disease-modifying treatment strategy for Parkinson's disease (PD) by stabilization of Glucocerebrosidase (GCase) enzyme by chaperones is of particular interest. Wild-type rat is a widely used animal model for PD; however, the in-silico model to eluci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45607e4e77c072d0e23bb02336c714d9
https://doi.org/10.1016/j.bioorg.2022.105871
https://doi.org/10.1016/j.bioorg.2022.105871