Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Pratibha Mehta Luthra"'
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113838- (2022)
Neuronal nitric oxide synthase (nNOS) is an enzyme constitutively expressed in the mammalian brain and skeletal muscles. The excessive activation of nNOS in the neurons results in oxidative and nitrosative stress associated with neuronal loss in vari
Externí odkaz:
https://doaj.org/article/d37ccb95567f47328ac7e39347e32c47
Publikováno v:
World Journal of Advanced Research and Reviews. 16:884-892
Both carbazole and thiosemicarbazide scaffold showed various potential biological activities in medicinal chemistry. In this research work, we synthesized a series of carbazole bearing thiosemicarbazide derivatives (17-28) and evaluated thierin vitro
Publikováno v:
International Journal of Advanced Research. 9:874-883
Pyranocarbazole alkaloids isolated from natural sources various plant parts of the flower-bearing geneses plants Murraya, Clausena, Glycosmis, species belongs to family Rutaceae. These pyranocarbazole alkaloids showed potential anticancer activities
Publikováno v:
Biochimica et biophysica acta. General subjects. 1866(12)
Stimulation of Asub2A/subreceptors (Asub2A/subR) coupled to Gsubs/sub/olf protein activates Adenylyl cyclase (AC) leading to the release of cAMP which activates the cAMP-dependent PKA phosphorylation. The possible role of Asub2A/subR in the modulatio
Publikováno v:
New Journal of Chemistry. 45:6693-6708
The present study documents the first investigation into the relationship between the binding and cleavage activity of nickel complexes towards DNA and proteins. Here, three different NiII complexes of the general type [Ni(nal)2diimine] (1a and 1b) a
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1866:130242
Pyranocarbazole alkaloids isolated from natural sources various plant parts of the flower-bearing geneses plantsMurraya,Clausena,Glycosmis, species belongs to family Rutaceae. These pyranocarbazole alkaloids showed potential anticancer activities on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2681f905e46b5e45f5103f944f2f64
Publikováno v:
Toxicology and Applied Pharmacology. 356:76-89
Recently, we have reported that Demethoxycurcumin induced Reactive oxygen species via inhibition of Mitochondrial Superoxide Dismutase is an initial event to trigger apoptosis through caspase-8 and 9 activation and to inhibit Akt/NF-κB survival sign
Autor:
Nitin Kumar, Pratibha Mehta Luthra
Publikováno v:
Mini reviews in medicinal chemistry. 21(19)
Abstract: The carbazole skeleton, a key structural motif occurring naturally or chemically synthesized, showed various biological activities. Molecular hybridization based on the combination of two or more bioactive pharmacophores has been an importa
Publikováno v:
Toxicology and Applied Pharmacology. 345:75-93
Earlier, we reported that Demethoxycurcumin (DMC) suppressed the growth of human glioma U87 MG cells by downregulation of Bcl-2 expression. In the present work, we investigated the DMC induced reactive oxygen species (ROS) mediated anti-proliferative