Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Pratibha C Koneru"'
Autor:
Tatsuya Maehigashi, Seohyun Ahn, Uk-Il Kim, Jared Lindenberger, Adrian Oo, Pratibha C Koneru, Bijan Mahboubi, Alan N Engelman, Mamuka Kvaratskhelia, Kyungjin Kim, Baek Kim
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009671 (2021)
Allosteric integrase inhibitors (ALLINIs) are a class of experimental anti-HIV agents that target the noncatalytic sites of the viral integrase (IN) and interfere with the IN-viral RNA interaction during viral maturation. Here, we report a highly pot
Externí odkaz:
https://doaj.org/article/08f9da231eaa4056b8d8eda2abea8078
Autor:
Jennifer L Elliott, Jenna E Eschbach, Pratibha C Koneru, Wen Li, Maritza Puray-Chavez, Dana Townsend, Dana Q Lawson, Alan N Engelman, Mamuka Kvaratskhelia, Sebla B Kutluay
Publikováno v:
eLife, Vol 9 (2020)
A large number of human immunodeficiency virus 1 (HIV-1) integrase (IN) alterations, referred to as class II substitutions, exhibit pleiotropic effects during virus replication. However, the underlying mechanism for the class II phenotype is not know
Externí odkaz:
https://doaj.org/article/fc785895057f4094b8a248a31422ab37
HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
Autor:
Pratibha C Koneru, Ashwanth C Francis, Nanjie Deng, Stephanie V Rebensburg, Ashley C Hoyte, Jared Lindenberger, Daniel Adu-Ampratwum, Ross C Larue, Michael F Wempe, Alan N Engelman, Dmitry Lyumkis, James R Fuchs, Ronald M Levy, Gregory B Melikyan, Mamuka Kvaratskhelia
Publikováno v:
eLife, Vol 8 (2019)
Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral agents that disrupt proper viral maturation by inducing hyper-multimerization of IN. Here we show that lead pyridine-based ALLINI KF116 exhibits striking
Externí odkaz:
https://doaj.org/article/f3f96045b25c4b55a0b26306772c43fd
Autor:
Christopher Fotsch, Debaleena Basu, Ryan Case, Qing Chen, Pratibha C. Koneru, Mei-Chu Lo, Rachel Ngo, Pooja Sharma, Amit Vaish, Xiang Yi, Stephan G. Zech, Peter Hodder
Publikováno v:
SLAS Discovery, Vol 29, Iss 4, Pp 100159- (2024)
To confirm target engagement of hits from our high-throughput screening efforts, we ran biophysical assays on several hundreds of hits from 15 different high-throughput screening campaigns. Analyzing the biophysical assay results from these screening
Externí odkaz:
https://doaj.org/article/2deb87592cfb4d24ab3ef0bdbdb9d00b
Autor:
Daniel Adu-Ampratwum, Yuhan Pan, Pratibha C. Koneru, Janet Antwi, Ashley C. Hoyte, Jacques Kessl, Patrick R. Griffin, Mamuka Kvaratskhelia, James R. Fuchs, Ross C. Larue
Publikováno v:
ACS Omega, Vol 7, Iss 5, Pp 4482-4491 (2022)
Human immunodeficiency virus-1 (HIV-1) is the causative agent of acquired immunodeficiency syndrome (AIDS). HIV-1, like all retroviruses, stably integrates its vDNA copy into host chromatin, a process allowing for permanent infection. This essential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e52cb078592a95419d703bed0e2c8b19
https://doi.org/10.1021/acsomega.1c06378
https://doi.org/10.1021/acsomega.1c06378
HIV-1 integrase binding to genomic RNA 5′-UTR induces local structural changes in vitro and in virio
Autor:
Mamuka Kvaratskhelia, Pratibha C. Koneru, Alan Engelman, Karin Musier-Forsyth, Chathuri Pathirage, Shuohui Liu, Wen Li
Publikováno v:
Retrovirology
Retrovirology, Vol 18, Iss 1, Pp 1-16 (2021)
Retrovirology, Vol 18, Iss 1, Pp 1-16 (2021)
Background During HIV-1 maturation, Gag and Gag-Pol polyproteins are proteolytically cleaved and the capsid protein polymerizes to form the honeycomb capsid lattice. HIV-1 integrase (IN) binds the viral genomic RNA (gRNA) and impairment of IN-gRNA bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0fd563ff1a8766289178c125f53960
https://doi.org/10.1186/s12977-021-00582-0
https://doi.org/10.1186/s12977-021-00582-0
Autor:
Pratibha C. Koneru, Mamuka Kvaratskhelia, Maritza Puray Chavez, Dana Q. Lawson, Jenna E. Eschbach, Alan Engelman, Jennifer L Elliott, Wen Li, Sebla B. Kutluay, Dana Townsend
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
A large number of human immunodeficiency virus 1 (HIV-1) integrase (IN) alterations, referred to as class II substitutions, exhibit pleiotropic effects during virus replication. However, the underlying mechanism for the class II phenotype is not know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8d19ccf39ad59f6498ec99dcdfdcec
https://elifesciences.org/articles/54311
https://elifesciences.org/articles/54311
Autor:
Jenna E. Eschbach, Maritza Puray-Chavez, Mamuka Kvaratskhelia, Sebla B. Kutluay, Alan Engelman, Jennifer L Elliott, Dana Townsend, Wen Li, Pratibha C. Koneru, Dana Q. Lawson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3007698830dfa26916b7a9518ca9c1d0
https://doi.org/10.7554/elife.54311.sa2
https://doi.org/10.7554/elife.54311.sa2
Autor:
Alan Engelman, James R. Fuchs, Pratibha C. Koneru, Ross C. Larue, Matthew J. Kobe, Augusta Jamin, Mamuka Kvaratskhelia, Ashley C. Hoyte
Publikováno v:
Journal of Biological Chemistry. 292:19814-19825
The pyridine-based multimerization selective HIV-1 integrase (IN) inhibitors (MINIs) are a distinct subclass of allosteric IN inhibitors. MINIs potently inhibit HIV-1 replication during virion maturation by inducing hyper- or aberrant IN multimerizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1051a497abff0af33a10fe9058114d86
https://doi.org/10.1074/jbc.m117.816645
https://doi.org/10.1074/jbc.m117.816645
Autor:
Mamuka Kvaratskhelia, Pratibha C. Koneru, Ettore Novellino, Nicolino Pala, Vincenzo Maria D'Amore, Francesca Esposito, Adele Sanna, Sandro Cosconati, Nicole Grandi, Enzo Tramontano, Francesco Saverio Di Leva, Lieve Naesens, Angela Corona, Roberto Di Santo, Mario Sechi
Publikováno v:
Antiviral research. 174
The management of Human Immunodeficiency Virus type 1 (HIV-1) infection requires life-long treatment that is associated with chronic toxicity and possible selection of drug-resistant strains. A new opportunity for drug intervention is offered by anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce57faf0c2e21095ad4b004e05846e4b
https://pubmed.ncbi.nlm.nih.gov/31812637
https://pubmed.ncbi.nlm.nih.gov/31812637