Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Prathyusha, Konda"'
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112978- (2023)
Summary: The success of precision oncology—which aims to match the right therapies to the right patients based on molecular status—is predicated on a robust pipeline of molecular targets against which therapies can be developed. Recent advances i
Externí odkaz:
https://doaj.org/article/e2a9b918547f404dbffa2454a9fc8ff9
Autor:
Barry E. Kennedy, Michael Giacomantonio, J. Patrick Murphy, Samuel Cutler, Maryanne Sadek, Prathyusha Konda, Joao A. Paulo, Gopal P. Pathak, Saskia H.J. Renkens, Stacy Grieve, Jonathan Pol, Steven P. Gygi, Christopher Richardson, Daniel Gaston, Anthony Reiman, Guido Kroemer, Manal O. Elnenaei, Shashi A. Gujar
Publikováno v:
Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 695-706 (2022)
Cancer cell energy metabolism plays an important role in dictating the efficacy of oncolysis by oncolytic viruses. To understand the role of multiple myeloma metabolism in reovirus oncolysis, we performed semi-targeted mass spectrometry-based metabol
Externí odkaz:
https://doaj.org/article/bb8aca67d04a4d08ab5cbfd23667f48e
Autor:
Namit Holay, Barry E. Kennedy, J. Patrick Murphy, Prathyusha Konda, Michael Giacomantonio, Tatjana Brauer-Chapin, Joao A. Paulo, Vishnupriyan Kumar, Youra Kim, Mariam Elaghil, Gary Sisson, Derek Clements, Christopher Richardson, Steven P. Gygi, Shashi Gujar
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
CD8 T cells play a central role in antiviral immunity. Type I interferons are among the earliest responders after virus exposure and can cause extensive reprogramming and antigen-independent bystander activation of CD8 T cells. Although bystander act
Externí odkaz:
https://doaj.org/article/43247c5da956443a994817e22e2a9b5e
Publikováno v:
eLife, Vol 11 (2022)
A splice variant of the androgen receptor that drives prostate cancer resistance translocates into the nucleus using a different mechanism from the full-length receptor and exhibits distinct molecular properties once inside.
Externí odkaz:
https://doaj.org/article/e8bdecead21340bbb6a6fe8073da6ab9
Autor:
Prathyusha Konda, Liubov M. Lifshits, John A. Roque, Houston D. Cole, Colin G. Cameron, Sherri A. McFarland, Shashi Gujar
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic c
Externí odkaz:
https://doaj.org/article/cd53397beefa46e8a7d7ee5b20571408
Autor:
Adil Mohamed, Prathyusha Konda, Heather E Eaton, Shashi Gujar, James R Smiley, Maya Shmulevitz
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008803 (2020)
The Dearing isolate of Mammalian orthoreovirus (T3D) is a prominent model of virus-host relationships and a candidate oncolytic virotherapy. Closely related laboratory strains of T3D, originating from the same ancestral T3D isolate, were recently fou
Externí odkaz:
https://doaj.org/article/3a7b10fcfd1c4abc9371650092406963
Autor:
Shashi Gujar, Yassine El Hiani, Michael A. Giacomantonio, Gopal P. Pathak, Youra Kim, Namit Holay, Prathyusha Konda, Derek R. Clements, John Patrick Murphy, Barry E. Kennedy
Oncolytic viruses (OV) such as reovirus preferentially infect and kill cancer cells. Thus, the mechanisms that dictate the susceptibility of cancer cells to OV-induced cytotoxicity hold the key to their success in clinics. Here, we investigated wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f851798f8be89f8b7de8621f0d9e167
https://doi.org/10.1158/0008-5472.c.6510912.v1
https://doi.org/10.1158/0008-5472.c.6510912.v1
Autor:
Shashi Gujar, Yassine El Hiani, Michael A. Giacomantonio, Gopal P. Pathak, Youra Kim, Namit Holay, Prathyusha Konda, Derek R. Clements, John Patrick Murphy, Barry E. Kennedy
Raw values for all in vitro and in vivo metabolomic experiments are presented in supplemental tables 1, 7, and 8. Supplemental tables 2, 3, 4, and 5 contain the correlation values and enrichment analysis for all experiments. Supplemental table 6 cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be45bb251be0090da201afb85f9dde3
https://doi.org/10.1158/0008-5472.22421382
https://doi.org/10.1158/0008-5472.22421382
Autor:
Sherri A. McFarland, S.D. Kim, Houston D. Cole, Susan Monro, Randolph P. Thummel, Prathyusha Konda, Colin G. Cameron, Shashi Gujar, Gagan Deep, John Roque, Liubov M. Lifshits, David von Dohlen
Publikováno v:
Chemical Science
Mounting evidence over the past 20 years suggests that photodynamic therapy (PDT), an anticancer modality known mostly as a local treatment, has the capacity to invoke a systemic antitumor immune response, leading to protection against tumor recurren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28134ca36bb4489c5ba2d3e3a8a0329c
https://doi.org/10.1039/d0sc03875j
https://doi.org/10.1039/d0sc03875j
Autor:
Prathyusha, Konda, John A, Roque Iii, Liubov M, Lifshits, Angelita, Alcos, Eissa, Azzam, Ge, Shi, Colin G, Cameron, Sherri A, McFarland, Shashi, Gujar
Publikováno v:
Am J Cancer Res
Cancer therapies that generate T cell-based anti-cancer immune responses are critical for clinical success and are favored over traditional therapies. One way to elicit T cell immune responses and generate long-lasting anti-cancer immunity is through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7862d79c9665e07a3cf02f2efddf66ed
https://pubmed.ncbi.nlm.nih.gov/35141014
https://pubmed.ncbi.nlm.nih.gov/35141014