Heightened Levels of Antimicrobial Response Factors in Patients With Rheumatoid Arthritis

Autor: Prathapan Ayyappan, Robert Z. Harms, Jennifer A. Seifert, Elizabeth A. Bemis, Marie L. Feser, Kevin D. Deane, M. Kristen Demoruelle, Ted R. Mikuls, V. Michael Holers, Nora E. Sarvetnick

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Rheumatoid arthritis (RA) is a chronic progressive autoimmune disease leading to considerable disability over time. The disease can be characterized by the presence of multiple autoantibodies in the serum and synovial fluid. Microbial dysbiosis is pr

Externí odkaz: https://doaj.org/article/547392a0899d44998b4eb8c047e4d725

Impact of Prenatal Exposure to Maternal Diabetes and High-Fat Diet on Postnatal Myocardial Ketone Body Metabolism in Rats

Autor: Prathapan Ayyappan, Tricia D. Larsen, Tyler C. T. Gandy, Eli J. Louwagie, Michelle L. Baack

Publikováno v: International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3684

Infants exposed to diabetic pregnancy are at higher risk of cardiomyopathy at birth and early onset cardiovascular disease (CVD) as adults. Using a rat model, we showed how fetal exposure to maternal diabetes causes cardiac disease through fuel-media

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2ba161809b54c70bf81df2147ec2bd

Time course of changes in oxidative stress and stress-induced proteins in cardiomyocytes exposed to doxorubicin and prevention by vitamin C.

Autor: Ana Ludke, Gauri Akolkar, Prathapan Ayyappan, Anita K Sharma, Pawan K Singal

Publikováno v: PLoS ONE, Vol 12, Iss 7, p e0179452 (2017)

We previously reported that Vitamin C (Vit C) protects against doxorubicin (Dox)-induced cardiotoxicity by reducing oxidative stress, p38 mitogen-activated kinase (MAPK) and p53 activation and rescuing cell death in isolated adult cardiomyocytes. The

Externí odkaz: https://doaj.org/article/6f1a5ca208d9417ab47b8c7f01b609c5

Arsenic: An Environmental Toxicant-Induced Oxidative Stress and Carcinogenesis

Autor: Harikumaran Nair R, M. Abhilash, Mathews Valuparampil Varghese, Prathapan Ayyappan

Publikováno v: Handbook of Oxidative Stress in Cancer: Mechanistic Aspects ISBN: 9789811545016
Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e99faaaa365f61adaffa5b97ab01c7
https://doi.org/10.1007/978-981-15-9411-3_40

Vitamin C mitigates oxidative/nitrosative stress and inflammation in doxorubicin-induced cardiomyopathy

Autor: Davinder S. Jassal, Vera Maria Cury Salemi, Kátia De Angelis, Gauri Akolkar, Danielle da Silva Dias, Maria Claudia Irigoyen, Pawan K. Singal, Prathapan Ayyappan, Ashim K. Bagchi

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 313:H795-H809

Increase in oxidative/nitrosative stress is one of the mechanisms associated with the development of cardiotoxicity due to doxorubicin (Dox), a potent chemotherapy drug. Previously, we reported mitigation of Dox-induced oxidative/nitrosative stress a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57875b0118646d7faad7140e72988a8d
https://doi.org/10.1152/ajpheart.00253.2017