Zobrazeno 1 - 10
of 1 374
pro vyhledávání: '"Prateek Kumar"'
Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology
Autor:
Annie M. Goettemoeller, Emmie Banks, Prateek Kumar, Viktor J. Olah, Katharine E. McCann, Kelly South, Christina C. Ramelow, Anna Eaton, Duc M. Duong, Nicholas T. Seyfried, David Weinshenker, Srikant Rangaraju, Matthew J. M. Rowan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Preventative treatment for Alzheimer’s Disease (AD) is dire, yet mechanisms underlying early regional vulnerability remain unknown. In AD, one of the earliest pathophysiological correlates to cognitive decline is hyperexcitability, which i
Externí odkaz:
https://doaj.org/article/472c8a45309c4ce99d27485c1bbd846b
Autor:
Prateek Kumar, Annie M. Goettemoeller, Claudia Espinosa-Garcia, Brendan R. Tobin, Ali Tfaily, Ruth S. Nelson, Aditya Natu, Eric B. Dammer, Juliet V. Santiago, Sneha Malepati, Lihong Cheng, Hailian Xiao, Duc D. Duong, Nicholas T. Seyfried, Levi B. Wood, Matthew J. M. Rowan, Srikant Rangaraju
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-26 (2024)
Abstract Dysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer’s Disease (AD). Defining early proteomic alterations in PV-INs can provide key biological and translationally
Externí odkaz:
https://doaj.org/article/4a3d7575d66340e7b52ba0e5a848ab2b
Publikováno v:
Annals of Indian Academy of Neurology, Vol 27, Iss 3, Pp 338-340 (2024)
Externí odkaz:
https://doaj.org/article/24eff28f12d3484eb6a6d8ae888317b3
Autor:
Balamurugan Nagarajan, Vykuntaraju K. Gowda, Sangeetha Yoganathan, Indar Kumar Sharawat, Kavita Srivastava, Nitish Vora, Rahul Badheka, Sumita Danda, Umesh Kalane, Anupriya Kaur, Priyanka Madaan, Sanjiv Mehta, Sandeep Negi, Prateek Kumar Panda, Surekha Rajadhyaksha, Arushi Gahlot Saini, Lokesh Saini, Siddharth Shah, Varunvenkat M. Srinivasan, Renu Suthar, Maya Thomas, Sameer Vyas, Naveen Sankhyan, Jitendra Kumar Sahu
Publikováno v:
Epilepsia Open, Vol 8, Iss 4, Pp 1383-1404 (2023)
Abstract Objective Literature on the genotypic spectrum of Infantile Epileptic Spasms Syndrome (IESS) in children is scarce in developing countries. This multicentre collaboration evaluated the genotypic and phenotypic landscape of genetic IESS in In
Externí odkaz:
https://doaj.org/article/2042c5f568e642f6a08dd0240ef34435
Autor:
Taniya Bhardwaj, Kundlik Gadhave, Shivani K. Kapuganti, Prateek Kumar, Zacharias Faidon Brotzakis, Kumar Udit Saumya, Namyashree Nayak, Ankur Kumar, Richa Joshi, Bodhidipra Mukherjee, Aparna Bhardwaj, Krishan Gopal Thakur, Neha Garg, Michele Vendruscolo, Rajanish Giri
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Bhardwaj et al., have explored the proteomes of SARS-CoV and SARS-CoV-2, and have demonstrated the amyloid formation of viral proteins, in vitro, through diverse biophysical techniques.
Externí odkaz:
https://doaj.org/article/2c66476a47044cdbb6efc553451a9fce
Publikováno v:
Annals of Indian Academy of Neurology, Vol 26, Iss 4, Pp 453-460 (2023)
Introduction: There is no bedside clinical examination-based prediction score for Duchenne muscular dystrophy/Becker muscular dystrophy (DMD/BMD) in children with neuromuscular diseases (NMDs) presenting with proximal limb-girdle weakness. Methods: W
Externí odkaz:
https://doaj.org/article/027dd9aec41d46d9899a0062df06f6b2
Autor:
Prateek Kumar Panda, Aman Elwadhi, Soura Dasgupta, Diksha Gupta, Apurva Tomar, Indar Kumar Sharawat
Publikováno v:
Annals of Indian Academy of Neurology, Vol 26, Iss 5, Pp 829-831 (2023)
Externí odkaz:
https://doaj.org/article/c31f3cb63b9a4d5081da120799cdfae3
Autor:
Ram Narayan Kurmi, Laxman Mandal, Raj Singh, Prateek Kumar Chaudhary, Tirth Dhungana, Sandesh Lamichanne, Nimish Raj Bastola, Prajjwal Pokharel
Publikováno v:
Journal of Nepal Medical Association, Vol 61, Iss 260 (2023)
Introduction: Stroke is the second most common cause of mortality after ischemic heart disease and the leading cause of morbidity around the world. This study aimed to find out the stroke among patients admitted to a tertiary care centre. Methods:
Externí odkaz:
https://doaj.org/article/8fb4e2c32f684ddcad257c22994cb711
Autor:
Sruti Rayaprolu, Sara Bitarafan, Juliet V. Santiago, Ranjita Betarbet, Sydney Sunna, Lihong Cheng, Hailian Xiao, Ruth S. Nelson, Prateek Kumar, Pritha Bagchi, Duc M. Duong, Annie M. Goettemoeller, Viktor János Oláh, Matt Rowan, Allan I. Levey, Levi B. Wood, Nicholas T. Seyfried, Srikant Rangaraju
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Current isolation-based approaches for cell type-specific proteomics pose several challenges. Here, the authors present an approach for in vivo cell type-specific protein labeling to characterize proteomic differences between neurons and astrocytes i
Externí odkaz:
https://doaj.org/article/0366b13af39b4d438b5baee2a2a9c33d
Autor:
Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell Hansen, Alena Kozlova, Sara Bitarafan, Prateek Kumar, David Beaulieu-Abdelahad, Xiaolin Zhang, Lisa Collier, Charles Szekeres, Levi B. Wood, Jubao Duan, Gopal Thinakaran, Srikant Rangaraju
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-27 (2022)
Abstract Background The BIN1 locus contains the second-most significant genetic risk factor for late-onset Alzheimer’s disease. BIN1 undergoes alternate splicing to generate tissue- and cell-type-specific BIN1 isoforms, which regulate membrane dyna
Externí odkaz:
https://doaj.org/article/5b885f3d291245d3b19ec792e0b820ed