Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Prateek Kulkarni"'
Autor:
Reetobrata Basu, Yanrong Qian, Samuel Mathes, Joseph Terry, Nathan Arnett, Trent Riddell, Austin Stevens, Kevin Funk, Stephen Bell, Zac Bokal, Courtney Batten, Cole Smith, Isaac Mendez-Gibson, Silvana Duran-Ortiz, Grace Lach, Patricia Alexandra Mora-Criollo, Prateek Kulkarni, Emily Davis, Elizabeth Teaford, Darlene E. Berryman, Edward O. List, Sebastian Neggers, John J. Kopchick
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Knockdown of GH receptor (GHR) in melanoma cells in vitro downregulates ATP-binding cassette-containing (ABC) transporters and sensitizes them to anti-cancer drug treatments. Here we aimed to determine whether a GHR antagonist (GHRA) could control ca
Externí odkaz:
https://doaj.org/article/d2ffbe802ebd4cbd9ac35e71d0449a98
Autor:
Edward O. List, Darlene E. Berryman, Elizabeth A. Jensen, Prateek Kulkarni, Savannah McKenna, John J. Kopchick
Publikováno v:
Archives of Endocrinology and Metabolism, Vol 63, Iss 6, Pp 557-567 (2020)
ABSTRACT In order to provide new insights into the various activities of GH in specific tissues, recent advances have allowed for the generation of tissue-specific GHR knockout mice. To date, 21 distinct tissue-specific mouse lines have been created
Externí odkaz:
https://doaj.org/article/aac410e6603b4e83a5765e8bbcdbc3f7
Autor:
Shoshana Yakar, Yanrong Qian, Edward O. List, Darlene E. Berryman, Prateek Kulkarni, Silvana Duran-Ortiz, Yuji Ikeno, Reetobrata Basu, Stephen Bell, John J. Kopchick, Samuel Mathes, Kevin Funk, Jonathan A. Young, Todd McHugh
Publikováno v:
Aging Cell
Studies in multiple species indicate that reducing growth hormone (GH) action enhances healthy lifespan. In fact, GH receptor knockout (GHRKO) mice hold the Methuselah prize for the world's longest‐lived laboratory mouse. We previously demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68a41895267339681bb4651502a68bc
https://doi.org/10.1111/acel.13506
https://doi.org/10.1111/acel.13506
Autor:
Emily Davis, Yanrong Qian, Stephen Bell, John J. Kopchick, Jolie Bogart, Silvana Duran-Ortiz, Shigeru Okada, Reetobrata Basu, Julie Slyby, Darlene E. Berryman, Alison Brittain, Edward O. List, Kevin Funk, Diego Ibarra, Jonathan A. Young, Joseph Terry, Prateek Kulkarni, Patricia Mora-Criollo, Mat Buchman, Elizabeth A. Jensen, Isaac Mendez-Gibson, Samuel Mathes
Publikováno v:
Pituitary
Much of our understanding of GH’s action stems from animal models and the generation and characterization of genetically altered or modified mice. Manipulation of genes in the GH/IGF1 family in animals started in 1982 when the first GH transgenic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8b72d3c15cafc122bbbdcc0ebb04e2
https://pubmed.ncbi.nlm.nih.gov/34797529
https://pubmed.ncbi.nlm.nih.gov/34797529
Publikováno v:
Cancer Research. 82:2620-2620
Pancreatic cancer is responsible for more than 48,000 deaths and 60,000 new cancer cases every year in the United States while the overall 5-year survival rate is only 10%. These numbers point towards an urgent need for new therapeutic approaches whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2df39324df297e81a51a025e9d98535
https://doi.org/10.1158/1538-7445.am2022-2620
https://doi.org/10.1158/1538-7445.am2022-2620
Autor:
Yanrong Qian, Reetobrata Basu, Samuel Mathes, Prateek Kulkarni, Emily Davis, Darlene Berryman, Edward List, Silvana Duran, John J. Kopchick
Publikováno v:
Cancer Research. 82:2621-2621
Knockdown of the growth hormone receptor (GHR) in melanoma cells downregulates ATP-binding cassette (ABC) transporters and sensitizes them to multiple drug treatments in vitro. The goal for this study is to understand whether a GHR antagonist (GHA) c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad26369d5c62d5107ff20fc52991cfc6
https://doi.org/10.1158/1538-7445.am2022-2621
https://doi.org/10.1158/1538-7445.am2022-2621
Publikováno v:
Cancer Research. 82:1004-1004
Melanoma is the most aggressive form of skin cancer with a dismal 5-year survival rate of 16% at the metastatic stage of the disease. Exosomes have recently emerged as a critical mediator of cancer therapy resistance by regulating epithelial to mesen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a364a4caec26a44199cd54d5d1ebaf09
https://doi.org/10.1158/1538-7445.am2022-1004
https://doi.org/10.1158/1538-7445.am2022-1004
The Effects of 20-kDa Human Placental GH in Male and Female GH-deficient Mice: An Improved Human GH?
Autor:
Prateek Kulkarni, Edward O. List, Reetobrata Basu, Kevin Funk, Shoshana Yakar, Jonathan A. Young, Elizabeth A. Jensen, Darlene E. Berryman, Mathew Buchman, Silvana Duran-Ortiz, Gozde Yildirim, John J. Kopchick, Yanrong Qian
Publikováno v:
Endocrinology. 161
A rare 20K isoform of GH-V (here abbreviated as GHv) was discovered in 1998. To date, only 1 research article has characterized this isoform in vivo, observing that GHv treatment in male high-fat fed rats had several GH-like activities, but unlike GH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea310996848e596045688b9c39b50c2
https://doi.org/10.1210/endocr/bqaa097
https://doi.org/10.1210/endocr/bqaa097
Publikováno v:
2020 International Conference on Mainstreaming Block Chain Implementation (ICOMBI).
Data is nowadays an invaluable resource; indeed, it guides all business decisions in most of the computer-aided human activities. Threats to data integrity are thus of paramount relevance, as tampering with data may maliciously affect crucial busines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa33aa006a7ccaff3f5afde8ca3d5877
https://doi.org/10.23919/icombi48604.2020.9203500
https://doi.org/10.23919/icombi48604.2020.9203500
Autor:
Prateek Kulkarni, B Ravishankar
Publikováno v:
2020 International Conference on Mainstreaming Block Chain Implementation (ICOMBI).
Block chain and AI are the most well liked technology trends, even if the 2 technologies have extremely completely different developing parties and applications, researchers are discussing and exploring their combinational applications. With integrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c2c0f1923bae5a6170d45592940ca82
https://doi.org/10.23919/icombi48604.2020.9203037
https://doi.org/10.23919/icombi48604.2020.9203037