Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Prasun K. Chakravarty"'
Autor:
Gagan Kukreja, Sophie Roy, Siddhartha De, Anita Chugh, Samuel D. Wright, Ravi P. Nargund, Suhas Tambe, Yogesh D. Shejul, Deepak B. Salunke, Michael P. Graziano, Jayasagar Gundu, Santosh Kurhade, Debnath Bhuniya, Kasim A. Mookhtiar, Sheo B. Singh, Joseph P. Vacca, Dhananjay N. Umrani, Bhavesh Dave, Minakshi Naykodi, Tian-Quan Cai, Sreemita Majumdar, Doris F. Cully, Prasun K. Chakravarty, Nadim S. Shaikh, Venkata P. Palle, Srinivasa B. Reddy, Prasad Shitole
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3596-3602
GPR91, a 7TM G-Protein-Coupled Receptor, has been recently deorphanized with succinic acid as its endogenous ligand. Current literature indicates that GPR91 plays role in various pathophysiology including renal hypertension, autoimmune disease and re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4824806ea8fdce58ee36cf56fffe0be4
https://doi.org/10.1016/j.bmcl.2011.04.091
https://doi.org/10.1016/j.bmcl.2011.04.091
Autor:
Brande S. Williams, Mathew J. Wyvratt, Sriram Tyagarajan, Vivien A. Warren, Catherine Abbadie, Brett Taylor, William J. Martin, Xiaohua Li, William H. Parsons, Nina Jochnowitz, Erin McGowan, Sanjeev Kumar, Ann E. Weber, Gregory J. Kaczorowski, Michael H. Fisher, Bishan Zhou, John P. Felix, Tracy Klatt, McHardy M. Smith, Birgit T. Priest, Prasun K. Chakravarty, Kathryn A. Lyons, Joseph L. Duffy, Ronsar Eid, Maria L. Garcia, Richard M. Brochu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7479-7482
A series of novel biphenyl pyrazole dicarboxamides were identified as potential sodium channel blockers for treatment of neuropathic pain. Compound 20 had outstanding efficacy in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44809e16a6cd04e26b06d5a57716c59e
https://doi.org/10.1016/j.bmcl.2010.10.017
https://doi.org/10.1016/j.bmcl.2010.10.017
Autor:
Peter T. Meinke, Dennis M. Schmatz, L.M. Gregory, Steven L. Colletti, Prasun K. Chakravarty, Steve Salva, Matthew J. Wyvratt, Wesley L. Shoop, Michelle B. Ayer, Chunshi Li, Thomas L. Shih, Michelle Zakson-Aiken, Dong Ok, Michael H. Fisher
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1751-1754
A series of new, diene-modified nodulisporic acid analogues ( 2 ) bearing diverse functionality at the 3″- and 4″-sites was efficiently prepared from the 3″-aldehyde 3 . Biological evaluation of these synthetic nodulisporic acid analogues for s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05d69f58a48520240ded8208c76c915
https://doi.org/10.1016/s0960-894x(02)00284-6
https://doi.org/10.1016/s0960-894x(02)00284-6
Autor:
Christine Snedden, Peter T. Meinke, Steve Salva, Matthew J. Wyvratt, Prasun K. Chakravarty, Thomas L. Shih, Sriram Tyagarajan, Michael H. Fisher
Publikováno v:
Organic Letters. 4:1291-1294
An efficient synthesis of the truncated 3"-aldehyde (3) from nodulisporic acid A (1) under mild conditions is described. Further oxidation of 3 to 3"-carboxylic acid (4) and its subsequent oxidative degradation produced 1"-aldehyde (5). These new der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b22822993812eede0e7589d2f3a7ae2
https://doi.org/10.1021/ol025766d
https://doi.org/10.1021/ol025766d
Publikováno v:
Tetrahedron Letters. 46:7889-7891
A simple, high yielding synthesis of pyrimidines from ketones in the presence of HMDS and formamide is described. Under microwave irradiation, heteroaromatic, aryl, aliphatic, and cyclic ketones cyclized to give pyrimidines in good yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2d672b4b9cd08ca7b7e3b54a45b803
https://doi.org/10.1016/j.tetlet.2005.09.094
https://doi.org/10.1016/j.tetlet.2005.09.094
Autor:
Catherine Abbadie, Vivien A. Warren, Xiaohua Li, James B Herrington, Gregory J. Kaczorowski, Shruti Mistry, Feng Ye, Andrew M. Swensen, Prasun K. Chakravarty, Rodolfo Haedo, Kathryn A. Lyons, Owen B. McManus, Randal M. Bugianesi, Mitchell D. Green, Shao Pengcheng Patrick, Maria L. Garcia, Shu-Yu Sun, McHardy M. Smith, Erin McGowan, Nina Jochnowitz, Joseph L. Duffy, Ge Dai
We report the investigation of sulfonamide-derived Cav2.2 inhibitors to address drug-metabolism liabilities with this lead class of analgesics. Modification of the benzamide substituent provided improvements in both potency and selectivity. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a14af3d556993551af77251b7d66937
https://europepmc.org/articles/PMC4027232/
https://europepmc.org/articles/PMC4027232/
Publikováno v:
Current Pharmaceutical Design. 1:317-324
Neurotensin (NT), a peptide hormone widely distributed in the CNS and GI tract of mammals, participates in a wide spectrum of central and peripheral biological functions by interacting with specific membrane bound receptors. Recently, NT receptors re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bd7f57a3d72d7b8bdb0d0ed2e4f1bab
https://doi.org/10.2174/1381612801666220919145004
https://doi.org/10.2174/1381612801666220919145004
Autor:
Prasun K. Chakravarty
Publikováno v:
Expert Opinion on Therapeutic Patents. 5:431-458
The primary and patent literature (July 1993 to February 1995) describing angiotensin II antagonists, renin inhibitors, angiotensin converting enzyme(ACE) inhibitors, endothelin antagonists, potassium channel agonist/openers, calcium channel blockers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcdde35f1c2f40dcf92eb2781ff952cf
https://doi.org/10.1517/13543776.5.5.431
https://doi.org/10.1517/13543776.5.5.431
Autor:
Robert A. Gabel, Theodore P. Broten, Gloria J. Zingaro, Linda W. Schaffer, Peter K. S. Siegl, Arthur A. Patchett, Terry W. Schorn, William J. Greenlee, Prasun K. Chakravarty, Elizabeth M. Naylor, Salah D. Kivlighn
Publikováno v:
American Journal of Hypertension. 8:58-66
MK-996, N-(4'-(5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl- methyl)1,1'-biphenyl-2-yl)-sulfonylbenzamide, is a potent, orally active, highly selective, nonpeptide angiotensin II (AII) receptor antagonist. MK-996 prevents the pressor response t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f55083766855f91ccf77204abbefbc5
https://doi.org/10.1016/0895-7061(94)00169-c
https://doi.org/10.1016/0895-7061(94)00169-c
Autor:
Xiaohua Li, Shao Pengcheng Patrick, Joseph L. Duffy, Rodolfo Haedo, Mitchell D. Green, Prasun K. Chakravarty, Gregory J. Kaczorowski, Maria L. Garcia, Ge Dai, Owen B. McManus, Kathryn A. Lyons, Shu-Yu Sun, Andrew M. Swensen, Nina Jochnowitz, Erin McGowan, Deepu J Varughese, Vivien A. Warren, Feng Ye, Catherine Abbadie, James B Herrington, Randal M. Bugianesi, Shruti Mistry, McHardy M. Smith
Publikováno v:
Journal of medicinal chemistry. 55(22)
The voltage-gated calcium channel Ca(v)2.2 (N-type calcium channel) is a critical regulator of synaptic transmission and has emerged as an attractive target for the treatment of chronic pain. We report here the discovery of sulfonamide-derived, state
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::894dc35e10efc8859a417daae4f28405
https://pubmed.ncbi.nlm.nih.gov/23098566
https://pubmed.ncbi.nlm.nih.gov/23098566