SIK1 localizes with nephrin in glomerular podocytes and its polymorphism predicts kidney injury.

Autor: Ferrandi M; Prassis Sigma-tau Research Institute, Via Forlanini, 3, Settimo Milanese, Milan, Italy.; Division of Genetics and Cell Biology, Genomics of Renal Diseases and Hypertension Unit., Molinari I; Prassis Sigma-tau Research Institute, Via Forlanini, 3, Settimo Milanese, Milan, Italy.; Division of Genetics and Cell Biology, Genomics of Renal Diseases and Hypertension Unit., Matafora V; Division of Genetics and Cell Biology, Biomolecular Mass Spectrometry Unit., Zerbini G; Division of Metabolic and Cardiovascular Sciences, Complications of Diabetes., Trevisani F; Department of Internal and Specialistic Medicine, San Raffaele Scientific Institute, Milan, Italy., Rastaldi MP; Renal Research Laboratory, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico & Fondazione D'Amico per la Ricerca Sulle Malattie Renali, Milan, Italy., Simonini M; Department of Internal and Specialistic Medicine, San Raffaele Scientific Institute, Milan, Italy., Giardino L; Renal Research Laboratory, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico & Fondazione D'Amico per la Ricerca Sulle Malattie Renali, Milan, Italy., Ferrari P; Prassis Sigma-tau Research Institute, Via Forlanini, 3, Settimo Milanese, Milan, Italy.; CVie Therapeutics, Hong Kong, China., Manunta P; Division of Genetics and Cell Biology, Genomics of Renal Diseases and Hypertension Unit.; Università Vita-Salute San Raffaele, San Raffaele Scientific Institute, Milan, Italy.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2017 Feb 01; Vol. 26 (3), pp. 660.

Rostafuroxin protects from podocyte injury and proteinuria induced by adducin genetic variants and ouabain.

Autor: Ferrandi M; Prassis Sigma-Tau Research Institute, Settimo Milanese, Milan, Italy (M.F., I.M., P.F.); Division of Genetics and Cell Biology, Genomics of Renal Diseases and Hypertension Unit, IRCC San Raffaele Scientific Institute, Milan, Italy (M.F., I.M., P.M.); Renal Research Laboratory, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico & Fondazione D'Amico per la Ricerca sulle Malattie Renali, Milan, Italy (M.P.R.); CVie Therapeutics, Hong Kong, China (P.F., G.B.); and Chair of Nephrology, University Vita-Salute, Milan, Italy (G.B., P.M.) mara.ferrandi@gmail.com., Molinari I; Prassis Sigma-Tau Research Institute, Settimo Milanese, Milan, Italy (M.F., I.M., P.F.); Division of Genetics and Cell Biology, Genomics of Renal Diseases and Hypertension Unit, IRCC San Raffaele Scientific Institute, Milan, Italy (M.F., I.M., P.M.); Renal Research Laboratory, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico & Fondazione D'Amico per la Ricerca sulle Malattie Renali, Milan, Italy (M.P.R.); CVie Therapeutics, Hong Kong, China (P.F., G.B.); and Chair of Nephrology, University Vita-Salute, Milan, Italy (G.B., P.M.)., Rastaldi MP; Prassis Sigma-Tau Research Institute, Settimo Milanese, Milan, Italy (M.F., I.M., P.F.); Division of Genetics and Cell Biology, Genomics of Renal Diseases and Hypertension Unit, IRCC San Raffaele Scientific Institute, Milan, Italy (M.F., I.M., P.M.); Renal Research Laboratory, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico & Fondazione D'Amico per la Ricerca sulle Malattie Renali, Milan, Italy (M.P.R.); CVie Therapeutics, Hong Kong, China (P.F., G.B.); and Chair of Nephrology, University Vita-Salute, Milan, Italy (G.B., P.M.)., Ferrari P; Prassis Sigma-Tau Research Institute, Settimo Milanese, Milan, Italy (M.F., I.M., P.F.); Division of Genetics and Cell Biology, Genomics of Renal Diseases and Hypertension Unit, IRCC San Raffaele Scientific Institute, Milan, Italy (M.F., I.M., P.M.); Renal Research Laboratory, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico & Fondazione D'Amico per la Ricerca sulle Malattie Renali, Milan, Italy (M.P.R.); CVie Therapeutics, Hong Kong, China (P.F., G.B.); and Chair of Nephrology, University Vita-Salute, Milan, Italy (G.B., P.M.)., Bianchi G; Prassis Sigma-Tau Research Institute, Settimo Milanese, Milan, Italy (M.F., I.M., P.F.); Division of Genetics and Cell Biology, Genomics of Renal Diseases and Hypertension Unit, IRCC San Raffaele Scientific Institute, Milan, Italy (M.F., I.M., P.M.); Renal Research Laboratory, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico & Fondazione D'Amico per la Ricerca sulle Malattie Renali, Milan, Italy (M.P.R.); CVie Therapeutics, Hong Kong, China (P.F., G.B.); and Chair of Nephrology, University Vita-Salute, Milan, Italy (G.B., P.M.)., Manunta P; Prassis Sigma-Tau Research Institute, Settimo Milanese, Milan, Italy (M.F., I.M., P.F.); Division of Genetics and Cell Biology, Genomics of Renal Diseases and Hypertension Unit, IRCC San Raffaele Scientific Institute, Milan, Italy (M.F., I.M., P.M.); Renal Research Laboratory, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico & Fondazione D'Amico per la Ricerca sulle Malattie Renali, Milan, Italy (M.P.R.); CVie Therapeutics, Hong Kong, China (P.F., G.B.); and Chair of Nephrology, University Vita-Salute, Milan, Italy (G.B., P.M.).

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2014 Nov; Vol. 351 (2), pp. 278-87. Date of Electronic Publication: 2014 Sep 03.

Lack of salt-inducible kinase 2 (SIK2) prevents the development of cardiac hypertrophy in response to chronic high-salt intake.

Autor: Popov S; Membrane Signaling Networks, Department of Medicine, Karolinska Institutet, CMM, Karolinska University Hospital-Solna, Stockholm, Sweden., Takemori H; Laboratory of Cell Signaling and Metabolism, National Institute for Biomedical Innovation, Osaka, Japan., Tokudome T; Department of Biochemistry, National Cerebral and Cardiovascular Research Institute, Osaka, Japan., Mao Y; Department of Biochemistry, National Cerebral and Cardiovascular Research Institute, Osaka, Japan., Otani K; Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Research Institute, Osaka, Japan., Mochizuki N; Cell Biology, National Cerebral and Cardiovascular Research Institute, Osaka, Japan., Pires N; BIAL - Portela & Ca, S.A., S. Mamede do Coronado, Portugal., Pinho MJ; MedInUP - Center for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal., Franco-Cereceda A; Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Torielli L; Prassis Sigma-Tau Research Institute, Settimo Milanese, Milan, Italy., Ferrandi M; Prassis Sigma-Tau Research Institute, Settimo Milanese, Milan, Italy., Hamsten A; Cardiovascular Genetics and Genomics, Department of Medicine, Karolinska Institutet, CMM, Karolinska University Hospital-Solna, Stockholm, Sweden., Soares-da-Silva P; BIAL - Portela & Ca, S.A., S. Mamede do Coronado, Portugal; MedInUP - Center for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal., Eriksson P; Cardiovascular Genetics and Genomics, Department of Medicine, Karolinska Institutet, CMM, Karolinska University Hospital-Solna, Stockholm, Sweden., Bertorello AM; Membrane Signaling Networks, Department of Medicine, Karolinska Institutet, CMM, Karolinska University Hospital-Solna, Stockholm, Sweden., Brion L; Membrane Signaling Networks, Department of Medicine, Karolinska Institutet, CMM, Karolinska University Hospital-Solna, Stockholm, Sweden.

Publikováno v: PloS one [PLoS One] 2014 Apr 21; Vol. 9 (4), pp. e95771. Date of Electronic Publication: 2014 Apr 21 (Print Publication: 2014).

Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 1: experimental studies.

Autor: Ferrandi M; Prassis sigma-tau Research Institute, Settimo Milanese, Milan 20019, Italy., Molinari I, Torielli L, Padoani G, Salardi S, Rastaldi MP, Ferrari P, Bianchi G

Publikováno v: Science translational medicine [Sci Transl Med] 2010 Nov 24; Vol. 2 (59), pp. 59ra86.

Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain.

Autor: Tripodi G; Prassis Sigma-Tau, Research Institute, Milan, Italy., Citterio L, Kouznetsova T, Lanzani C, Florio M, Modica R, Messaggio E, Hamlyn JM, Zagato L, Bianchi G, Staessen JA, Manunta P

Publikováno v: American journal of hypertension [Am J Hypertens] 2009 Apr; Vol. 22 (4), pp. 357-63. Date of Electronic Publication: 2009 Feb 05.