An open label trial of anakinra to prevent respiratory failure in covid-19

Autor: Kyriazopoulou, E. Panagopoulos, P. Metallidis, S. Dalekos, G.N. Poulakou, G. Gatselis, N. Karakike, E. Saridaki, M. Loli, G. Stefos, A. Prasianaki, D. Georgiadou, S. Tsachouridou, O. Petrakis, V. Tsiakos, K. Kosmidou, M. Lygoura, V. Dareioti, M. Milionis, H. Papanikolaou, I.C. Akinosoglou, K. Myrodia, D.-M. Gravvani, A. Stamou, A. Gkavogianni, T. Katrini, K. Marantos, T. Trontzas, I.P. Syrigos, K. Chatzis, L. Chatzis, S. Vechlidis, N. Avgoustou, C. Chalvatzis, S. Kyprianou, M. van der Meer, J.W.M. Eugen-Olsen, J. Netea, M.G. Giamarellos-Bourboulis, E.J.

Background It was studied if early suPAR-guided anakinra treatment can prevent severe respiratory failure (SRF) of COVID-19. Methods 130 patients with suPAR ≥6 ng/ml were assigned to subcutaneous anakinra 100mg once daily for 10 days. Primary outco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::7413aa627084b09fd3d3170b07c20071
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2997204

An open label trial of anakinra to prevent respiratory failure in COVID-19.

Autor: Kyriazopoulou E; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Panagopoulos P; 2nd Department of Internal Medicine, Democritus University of Thrace, Medical School, Alexandroupolis, Greece., Metallidis S; 1st Department of Internal Medicine, Aristotle University ofThessaloniki, Thessaloniki, Greece., Dalekos GN; Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Center of Greece in Autoimmune Liver Diseases, General University Hospital of Larissa, Larissa, Greece., Poulakou G; 3rd Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Gatselis N; Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Center of Greece in Autoimmune Liver Diseases, General University Hospital of Larissa, Larissa, Greece., Karakike E; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Saridaki M; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Loli G; 1st Department of Internal Medicine, Aristotle University ofThessaloniki, Thessaloniki, Greece., Stefos A; Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Center of Greece in Autoimmune Liver Diseases, General University Hospital of Larissa, Larissa, Greece., Prasianaki D; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Georgiadou S; Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Center of Greece in Autoimmune Liver Diseases, General University Hospital of Larissa, Larissa, Greece., Tsachouridou O; 1st Department of Internal Medicine, Aristotle University ofThessaloniki, Thessaloniki, Greece., Petrakis V; 2nd Department of Internal Medicine, Democritus University of Thrace, Medical School, Alexandroupolis, Greece., Tsiakos K; 3rd Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Kosmidou M; 1st Department of Internal Medicine,University of Ioannina, School of HealthSciences, Faculty of Medicine, Ioannina, Greece., Lygoura V; Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Center of Greece in Autoimmune Liver Diseases, General University Hospital of Larissa, Larissa, Greece., Dareioti M; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Milionis H; 1st Department of Internal Medicine,University of Ioannina, School of HealthSciences, Faculty of Medicine, Ioannina, Greece., Papanikolaou IC; Department of Pulmonary Medicine, General Hospital of Kerkyra, Kerkyra, Greece., Akinosoglou K; Department of Internal Medicine, University of Patras, Medical School, Rion, Greece., Myrodia DM; 3rd Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Gravvani A; 3rd Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Stamou A; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Gkavogianni T; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Katrini K; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Marantos T; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Trontzas IP; 3rd Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Syrigos K; 3rd Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Chatzis L; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Chatzis S; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Vechlidis N; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Avgoustou C; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Chalvatzis S; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., Kyprianou M; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece., van der Meer JW; Department of Internal Medicine and Center for Infectious Diseases, Radboud University, Nijmegen, Netherlands., Eugen-Olsen J; Clinical Research Centre, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Netea MG; Department of Internal Medicine and Center for Infectious Diseases, Radboud University, Nijmegen, Netherlands.; Immunology and Metabolism, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany., Giamarellos-Bourboulis EJ; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Publikováno v: ELife [Elife] 2021 Mar 08; Vol. 10. Date of Electronic Publication: 2021 Mar 08.

CD38 Coordinates with NF-κB to Promote Cochlear Inflammation in Noise-Induced Hearing Loss: the Protective Effect of Apigenin.

Autor: Liu D; Senior Department of Otolaryngology-Head & Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100853, China.; National Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China.; Key Lab of Hearing Science, Ministry of Education, Beijing, China.; Beijing Key Lab of Hearing Impairment for Prevention and Treatment, Beijing, China., Sai N; Senior Department of Otolaryngology-Head & Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100853, China.; National Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China.; Key Lab of Hearing Science, Ministry of Education, Beijing, China.; Beijing Key Lab of Hearing Impairment for Prevention and Treatment, Beijing, China., Zhou Y; Senior Department of Otolaryngology-Head & Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100853, China.; National Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China.; Key Lab of Hearing Science, Ministry of Education, Beijing, China.; Beijing Key Lab of Hearing Impairment for Prevention and Treatment, Beijing, China., Yu N; Senior Department of Otolaryngology-Head & Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100853, China.; National Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China.; Key Lab of Hearing Science, Ministry of Education, Beijing, China.; Beijing Key Lab of Hearing Impairment for Prevention and Treatment, Beijing, China., Jiang QQ; Senior Department of Otolaryngology-Head & Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100853, China.; National Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China.; Key Lab of Hearing Science, Ministry of Education, Beijing, China.; Beijing Key Lab of Hearing Impairment for Prevention and Treatment, Beijing, China., Sun W; Department of Communicative Disorders and Sciences, Center for Hearing and Deafness, the State University of New York at Buffalo, Buffalo, NY, USA., Han WJ; Senior Department of Otolaryngology-Head & Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100853, China. hanweiju@aliyun.com.; National Key Laboratory of Hearing and Balance Science, Beijing, China. hanweiju@aliyun.com.; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China. hanweiju@aliyun.com.; Key Lab of Hearing Science, Ministry of Education, Beijing, China. hanweiju@aliyun.com.; Beijing Key Lab of Hearing Impairment for Prevention and Treatment, Beijing, China. hanweiju@aliyun.com., Guo W; Senior Department of Otolaryngology-Head & Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100853, China. gwent001@163.com.; National Key Laboratory of Hearing and Balance Science, Beijing, China. gwent001@163.com.; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China. gwent001@163.com.; Key Lab of Hearing Science, Ministry of Education, Beijing, China. gwent001@163.com.; Beijing Key Lab of Hearing Impairment for Prevention and Treatment, Beijing, China. gwent001@163.com.

Publikováno v: Molecular neurobiology [Mol Neurobiol] 2024 Dec 27. Date of Electronic Publication: 2024 Dec 27.

suPAR cut-offs for stratification of low, medium, and high-risk acute medical patients in the emergency department.

Autor: Santeri, Seppälä¹ (AUTHOR) Santeri.Seppala@essote.fi, Peter, Andersen Andreas² (AUTHOR), Kristiina, Nyyssönen³ (AUTHOR), Jesper, Eugen-Olsen² (AUTHOR), Harri, Hyppölä¹ (AUTHOR)

Publikováno v: BMC Emergency Medicine. 11/29/2021, Vol. 21 Issue 1, p1-8. 8p.

NLRP3 inflammasome and interleukin-1 contributions to COVID-19-associated coagulopathy and immunothrombosis.

Autor: Potere, Nicola, Garrad, Evan, Kanthi, Yogendra, Nisio, Marcello Di, Kaplanski, Gilles, Bonaventura, Aldo, Connors, Jean Marie, Caterina, Raffaele De, Abbate, Antonio

Publikováno v: Cardiovascular Research; Aug2023, Vol. 119 Issue 11, p2046-2060, 15p