Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Prashi Jain"'
Autor:
Bryan C. Nikolai, Prashi Jain, David L. Cardenas, Brian York, Qin Feng, Neil J. McKenna, Subhamoy Dasgupta, David M. Lonard, Bert W. O’Malley
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract A subset of CD4 + lymphocytes, regulatory T cells (Tregs), are necessary for central tolerance and function as suppressors of autoimmunity against self-antigens. The SRC-3 coactivator is an oncogene in multiple cancers and is capable of pote
Externí odkaz:
https://doaj.org/article/c5aa049a9d6547ecb096ffd0b12d8bba
Autor:
Lyra Chang, James Campbell, Idris O. Raji, Shiva K. R. Guduru, Prasanna Kandel, Michelle Nguyen, Steven Liu, Kevin Tran, Navneet K. Venugopal, Bethany C. Taylor, Matthew V. Holt, Nicolas L. Young, Errol L. G. Samuel, Prashi Jain, Conrad Santini, Banumathi Sankaran, Kevin R. MacKenzie, Damian W. Young
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Despite the established roles of the epigenetic factor UHRF1 in oncogenesis, no UHRF1-targeting therapeutics have been reported to date. In this study, we use fragment-based ligand discovery to identify novel scaffolds for targeting the isol
Externí odkaz:
https://doaj.org/article/5972f93c7d5b4a20bcf0f3bca4897227
Autor:
Savita Bisht, Jens Nolting, Ute Schütte, Jens Haarmann, Prashi Jain, Dhruv Shah, Peter Brossart, Patrick Flaherty, Georg Feldmann
Publikováno v:
Translational Oncology, Vol 8, Iss 4, Pp 295-307 (2015)
Despite considerable progress in recent years, the overall prognosis of metastatic malignant melanoma remains poor, and curative therapeutic options are lacking. Therefore, better understanding of molecular mechanisms underlying melanoma progression
Externí odkaz:
https://doaj.org/article/8c4188bbd7ef4f0ba949e7acfb9e85c5
Publikováno v:
Acta Crystallographica Section E, Vol 64, Iss 7, Pp o1336-o1337 (2008)
There are two independent molecules in the asymmetric unit of the title compound, C11H13N3O3. The interplanar angles for the two rings of the benzimidazole ring system is 2.21 (12)° in one molecule and 0.72 (12)° in the other. The nitro group is tw
Externí odkaz:
https://doaj.org/article/e71307cbdef34686b5fbcee1cb598c05
Autor:
Sang Jun Han, Prashi Jain, Yosef Gilad, Yan Xia, Nuri Sung, Mi Jin Park, Adam M. Dean, Rainer B. Lanz, Jianming Xu, Clifford C. Dacso, David M. Lonard, Bert W. O’Malley
Publikováno v:
bioRxiv
sSteroid receptor coactivator 3 (SRC-3) is most strongly expressed in regulatory T cells (Tregs) and B cells, suggesting that it plays an important role in the regulation of Treg function. Using an aggressive E0771 mouse breast cell line syngeneic im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc78ca5dff5d6d0c68822d2e93dc8046
https://doi.org/10.1101/2023.03.28.534575
https://doi.org/10.1101/2023.03.28.534575
Autor:
Jin Wang, Dong Lu, Xiaobin Yu, David M. Lonard, David L. Cardenas, Xiaohui Peng, Prashi Jain, Li Qin, Yang Yu, Bert W. O'Malley, Jianwei Chen, Jianming Xu
Publikováno v:
Endocr Relat Cancer
Steroid receptor coactivators (SRCs) possess specific and distinct oncogenic roles in the initiation of cancer and in its progression to a more aggressive disease. These coactivators interact with nuclear receptors and other transcription factors to
Publikováno v:
Manual of Crime Scene Investigation ISBN: 9781003129554
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b493c5c2f54732fd875e32f69c41d6c
https://doi.org/10.4324/9781003129554-11
https://doi.org/10.4324/9781003129554-11
Autor:
Prashi Jain, Bryan C. Nikolai, Neil J. McKenna, Qin Feng, David M. Lonard, Brian York, Bert W. O'Malley, David L. Cardenas, Subhamoy Dasgupta
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports
Scientific Reports
A subset of CD4 + lymphocytes, regulatory T cells (Tregs), are necessary for central tolerance and function as suppressors of autoimmunity against self-antigens. The SRC-3 coactivator is an oncogene in multiple cancers and is capable of potentiating
Publikováno v:
Biology of Reproduction
JQ1 is a small-molecule inhibitor of the bromodomain and extra terminal (BET) protein family that potently inhibits the bromodomain testis-specific protein (BRDT), which is essential for spermatogenesis. JQ1 treatment produces a reversible contracept
Autor:
Kevin R. MacKenzie, Damian W. Young, Prashi Jain, Idris O. Raji, Conrad Santini, Brandon T Ebright, Srinivas Chamakuri
Publikováno v:
The Journal of Organic Chemistry. 84:6040-6064
The piperazine heterocycle is housed within a large number of FDA-approved drugs and biological probe compounds. Structurally, however, these compounds are mostly confined to substitutions on the two ring nitrogen atoms, rationalizing the expansion o