Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Prashanti Patil"'
Autor:
Paul D. Robbins, Kevin Ngo, Qing Dong, Tony Wyss-Coray, Nam Vo, Hongsheng Lin, Prashanti Patil, Debora Colangelo, Joon S. Lee, Laura J. Niedernhofer, Gwendolyn Sowa, Changbin Lei, Matthew J. Yousefzadeh, Vivian Li, Derek M. Huffman, Dong Wang, James M. Kang
Publikováno v:
Aging (Albany NY)
Whether disc aging is influenced by factors beyond its local environment is an important unresolved question. Here we performed heterochronic parabiosis in mice to study the effects of circulating factors in young and old blood on age-associated inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6725189e199e7defd5c5aec283cfff8
http://europepmc.org/articles/PMC7343497
http://europepmc.org/articles/PMC7343497
Autor:
Prashanti, Patil, Qing, Dong, Dong, Wang, Jianhui, Chang, Christopher, Wiley, Marco, Demaria, Joon, Lee, James, Kang, Laura J, Niedernhofer, Paul D, Robbins, Gwendolyn, Sowa, Judith, Campisi, Daohong, Zhou, Nam, Vo
Publikováno v:
Aging Cell
Rationale Age‐related changes in the intervertebral discs are the predominant contributors to back pain, a common physical and functional impairment experienced by older persons. Cellular senescence, a process wherein cells undergo growth arrest an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2a9e1fdcf2a4420c940f861d9419b6f7
https://pubmed.ncbi.nlm.nih.gov/30900385
https://pubmed.ncbi.nlm.nih.gov/30900385
Autor:
Gwendolyn Sowa, Daohong Zhou, Jianhui Chang, Christopher D. Wiley, Laura J. Niedernhofer, Judith Campisi, Qing Dong, Nam Vo, Paul D. Robbins, Prashanti Patil, Joon S. Lee, Dong Wang, Marco Demaria, James D. Kang
Publikováno v:
Aging Cell, 18(3):e12927. Wiley
Aging cell, vol 18, iss 3
Aging cell, vol 18, iss 3
Author(s): Patil, Prashanti; Dong, Qing; Wang, Dong; Chang, Jianhui; Wiley, Christopher; Demaria, Marco; Lee, Joon; Kang, James; Niedernhofer, Laura J; Robbins, Paul D; Sowa, Gwendolyn; Campisi, Judith; Zhou, Daohong; Vo, Nam | Abstract: RationaleAge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50fc1b7382e682108a0f9e1b7c519035
https://research.rug.nl/en/publications/305060f6-7c02-43e6-aee3-1915795fb19e
https://research.rug.nl/en/publications/305060f6-7c02-43e6-aee3-1915795fb19e
Autor:
Judith A. Hoyland, James D. Kang, Makarand V. Risbud, Robert A. Hartman, Gwendolyn Sowa, Nam Vo, James C. Iatridis, Dimitris Kletsas, Prashanti Patil, Christine L. Le Maitre
Publikováno v:
Journal of Orthopaedic Research. 34:1289-1306
Advanced age is the greatest risk factor for the majority of human ailments, including spine-related chronic disability and back pain, which stem from age-associated intervertebral disc degeneration (IDD). Given the rapid global rise in the aging pop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebf8f15165ae6b25538b92eb764c3936
https://doi.org/10.1002/jor.23195
https://doi.org/10.1002/jor.23195
Publikováno v:
Current molecular biology reports. 4(4)
Age is a major risk factor for multiple disease pathologies, including chronic back pain, which stems from age-related degenerative changes to intervertebral disc tissue. Growing evidence suggests that the change in phenotype of disc cells to a senes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff7575eeaee7a1b0a1d3516c23ff7bd
https://pubmed.ncbi.nlm.nih.gov/30473991
https://pubmed.ncbi.nlm.nih.gov/30473991
Autor:
Laura J. Niedernhofer, Paul D. Robbins, Robert Tisherman, Nam Vo, Fabrisia Ambrosio, Gwen Sowa, Prashanti Patil, B. Van Houten, C. St. Croix, Robert A. Hartman
Publikováno v:
European Cells & Materials, Vol 36, Pp 171-183 (2018)
Robust cellular bioenergetics is vital in the energy-demanding process of maintaining matrix homeostasis in the intervertebral disc. Age-related decline in disc cellular bioenergetics is hypothesised to contribute to the matrix homeostatic perturbati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2168b73b920d706d4ba859c9027b46d
https://pubmed.ncbi.nlm.nih.gov/30334244
https://pubmed.ncbi.nlm.nih.gov/30334244
Autor:
Claudette M. St. Croix, Dayeong Lee, Sruti Shiva, Joon S. Lee, Laura J. Niedernhofer, Ben Van Houten, Prashanti Patil, Micol Falabella, Sowa Gwendolyn, Paul D. Robbins, Nam Vo, Amal Saeed, Brett A. Kaufman
Publikováno v:
Mechanisms of ageing and development. 180
Cellular senescence is a phenotype characterized by irreversible growth arrest, chronic elevated secretion of proinflammatory cytokines and matrix proteases, a phenomenon known as senescence-associated secretory phenotype (SASP). Biomarkers of cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd37652bc32d2be4080dab200ef00f60
https://pubmed.ncbi.nlm.nih.gov/31002926
https://pubmed.ncbi.nlm.nih.gov/31002926
Autor:
Prashanti Patil, Nam Vo, Gwendolyn Sowa, James Kang, Sara J. McGowan, Laura J. Niedernhofer, Paul D. Robbins, Kevin Ngo
Publikováno v:
Mechanisms of ageing and development. 166
Aging greatly increases the risk for intervertebral disc degeneration (IDD) as a result of proteoglycan loss due to reduced synthesis and enhanced degradation of the disc matrix proteoglycan (PG). How disc matrix PG homeostasis becomes perturbed with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb3fe02892887ed487287526e53a9df
https://pubmed.ncbi.nlm.nih.gov/28830687
https://pubmed.ncbi.nlm.nih.gov/28830687
Autor:
Vivian Li, Derek M. Huffman, Kevin Ngo, Gwendolyn Sowa, Prashanti Patil, Changbin Lei, Nam Vo
Publikováno v:
The Spine Journal. 18:S62
BACKGROUND CONTEXT Aging is the main risk factor for intervertebral disc degeneration (IDD). Age-associated IDD could be due to the time-dependent accumulation of local damage to disc cells (cell autonomous) or global influences on disc tissue from t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68b492a5977c8c19769a5fe19bc18415
https://doi.org/10.1016/j.spinee.2018.06.391
https://doi.org/10.1016/j.spinee.2018.06.391