Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Prashanthi Dharanipragada"'
Autor:
Prashanthi Dharanipragada, Nita Parekh
Publikováno v:
Cells, Vol 12, Iss 4, p 596 (2023)
Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma and frequently develops through the accumulation of several genetic variations. With the advancement in high-throughput techniques, in addition to mutations and cop
Externí odkaz:
https://doaj.org/article/c51b7be6e33f45999af7d93d06f01a31
SeqVItA: Sequence Variant Identification and Annotation Platform for Next Generation Sequencing Data
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
The current trend in clinical data analysis is to understand how individuals respond to therapies and drug interactions based on their genetic makeup. This has led to a paradigm shift in healthcare; caring for patients is now 99% information and 1% i
Externí odkaz:
https://doaj.org/article/9bcf0f583c8a4cdd81b1a9534b2cf784
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195334 (2018)
Discovery of copy number variations (CNVs), a major category of structural variations, have dramatically changed our understanding of differences between individuals and provide an alternate paradigm for the genetic basis of human diseases. CNVs incl
Externí odkaz:
https://doaj.org/article/2de79bcbadc24315b0369e921e69944a
Autor:
Prashanthi Dharanipragada, Xiao Zhang, Sixue Liu, Shirley H. Lomeli, Aayoung Hong, Yan Wang, Zhentao Yang, Kara Z. Lo, Agustin Vega-Crespo, Antoni Ribas, Stergios J. Moschos, Gatien Moriceau, Roger S. Lo
Publikováno v:
Cancer discovery, vol 13, iss 4
Blocking cancer genomic instability may prevent tumor diversification and escape from therapies. We show that, after MAPK inhibitor (MAPKi) therapy in patients and mice bearing patient-derived xenografts (PDX), acquired resistant genomes of metastati
Autor:
King L. Hung, Jens Luebeck, Siavash R. Dehkordi, Caterina I. Colón, Rui Li, Ivy Tsz-Lo Wong, Ceyda Coruh, Prashanthi Dharanipragada, Shirley H. Lomeli, Natasha E. Weiser, Gatien Moriceau, Xiao Zhang, Chris Bailey, Kathleen E. Houlahan, Wenting Yang, Rocío Chamorro González, Charles Swanton, Christina Curtis, Mariam Jamal-Hanjani, Anton G. Henssen, Julie A. Law, William J. Greenleaf, Roger S. Lo, Paul S. Mischel, Vineet Bafna, Howard Y. Chang
Publikováno v:
Nature genetics, vol 54, iss 11
Extrachromosomal DNA (ecDNA) is a common mode of oncogene amplification but is challenging to analyze. Here, we adapt CRISPR-CATCH, in vitro CRISPR-Cas9 treatment and pulsed field gel electrophoresis of agarose-entrapped genomic DNA, previously devel
Autor:
Sixue Liu, Prashanthi Dharanipragada, Shirley H. Lomeli, Yan Wang, Xiao Zhang, Zhentao Yang, Raymond J. Lim, Camelia Dumitras, Philip O. Scumpia, Steve M. Dubinett, Gatien Moriceau, Douglas B. Johnson, Stergios J. Moschos, Roger S. Lo
Publikováno v:
Nature medicine, vol 29, iss 5
Metastasis and failure of present-day therapies represent the most common causes of mortality in patients with cutaneous melanoma. To identify the underlying genetic and transcriptomic landscapes, in this study we analyzed multi-organ metastases and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5318bf99218234a1a5a9d8f3309df644
https://escholarship.org/uc/item/62m629hn
https://escholarship.org/uc/item/62m629hn
Autor:
Thomas G. Graeber, Roger S. Lo, Vineet Bafna, Daniel S. Peeper, Asha S. Multani, P. Nagesh Rao, Paul J. Hergenrother, Kim H. Paraiso, T. Niroshi Senaratne, Stephen E. Motika, Amelia Palermo, Johanna ten Hoeve, Kyle Sheu, Salwan Alhani, Nikolas G. Balanis, Rachana Jayaraman, Gabriel Karin, Eli Pazol, Jesus Salazar, William P. Crosson, Trevor Ridgley, Prashanthi Dharanipragada, Oscar Krijgsman, Gatien Moriceau, Mark H. Goodman, Jens Luebeck, Shirley H. Lomeli, Siavash R. Dehkordi, Arthur Huang, Jenna K. Minami, Kai Song
Focal amplifications (FA) can mediate targeted therapy resistance in cancer. Understanding the structure and dynamics of FAs is critical for designing treatments that overcome plasticity-mediated resistance. We developed a melanoma model of dual MAPK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005496410afa192ef817de39cbb29907
https://doi.org/10.1158/2159-8290.c.6549616.v1
https://doi.org/10.1158/2159-8290.c.6549616.v1
Autor:
Roger S. Lo, Gatien Moriceau, Stergios J. Moschos, Antoni Ribas, Agustin Vega-Crespo, Kara Z. Lo, Zhentao Yang, Yan Wang, Aayoung Hong, Shirley H. Lomeli, Sixue Liu, Xiao Zhang, Prashanthi Dharanipragada
Supplementary Figure S1. Associations of CGRs and ecDNAs with ploidy, expression, and enhancers. Supplementary Figure S2. Analysis of chromothripsis, ecDNAs, and CGRs in MAPKi-sensitive/-naïve versus -resistant melanoma. Supplementary Figure S3. Inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6821b8ab7c86a2aba19e8b8987f693c4
https://doi.org/10.1158/2159-8290.22553401
https://doi.org/10.1158/2159-8290.22553401
Autor:
Thomas G. Graeber, Roger S. Lo, Vineet Bafna, Daniel S. Peeper, Asha S. Multani, P. Nagesh Rao, Paul J. Hergenrother, Kim H. Paraiso, T. Niroshi Senaratne, Stephen E. Motika, Amelia Palermo, Johanna ten Hoeve, Kyle Sheu, Salwan Alhani, Nikolas G. Balanis, Rachana Jayaraman, Gabriel Karin, Eli Pazol, Jesus Salazar, William P. Crosson, Trevor Ridgley, Prashanthi Dharanipragada, Oscar Krijgsman, Gatien Moriceau, Mark H. Goodman, Jens Luebeck, Shirley H. Lomeli, Siavash R. Dehkordi, Arthur Huang, Jenna K. Minami, Kai Song
Supplementary Table from Plasticity of Extrachromosomal and Intrachromosomal BRAF Amplifications in Overcoming Targeted Therapy Dosage Challenges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a8c4bd05ca644172e944aa05c3ccc9
https://doi.org/10.1158/2159-8290.22541326
https://doi.org/10.1158/2159-8290.22541326
Autor:
Roger S. Lo, Gatien Moriceau, Stergios J. Moschos, Antoni Ribas, Agustin Vega-Crespo, Kara Z. Lo, Zhentao Yang, Yan Wang, Aayoung Hong, Shirley H. Lomeli, Sixue Liu, Xiao Zhang, Prashanthi Dharanipragada
Blocking cancer genomic instability may prevent tumor diversification and escape from therapies. We show that, after MAPK inhibitor (MAPKi) therapy in patients and mice bearing patient-derived xenografts (PDX), acquired resistant genomes of metastati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82e1acfd90578c403daf87924920c16
https://doi.org/10.1158/2159-8290.c.6492995
https://doi.org/10.1158/2159-8290.c.6492995