Systemic Akt1 Deletion after Tumor Onset in p53−/− Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration

Autor: Wan-Ni Yu, Veronique Nogueira, Arya Sobhakumari, Krushna C. Patra, Prashanth T. Bhaskar, Nissim Hay

Publikováno v: Cell Reports, Vol 12, Iss 4, Pp 610-621 (2015)

Akt is frequently activated in human cancers. However, it is unknown whether systemic inhibition of a single Akt isoform could regress cancer progression in cancers that are not driven by Akt activation. We systemically deleted Akt1 after tumor onset

Externí odkaz: https://doaj.org/article/fbd2c6be520f4c5db88c47b7ad95aca1

A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis.

Autor: Blaha CS; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA., Ramakrishnan G; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA., Jeon SM; College of Pharmacy, Ajou University Yeongtong-gu, Suwon-si, Gyeonggi-do, 443-749, Korea. nhay@uic.edu., Nogueira V; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA., Rho H; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA., Kang S; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA., Bhaskar P; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA., Terry AR; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA., Aissa AF; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA., Frolov MV; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA., Patra KC; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA.; Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, 45267-0521, USA., Brooks Robey R; Veterans Affairs Medical Center, White River Junction, Hartford, VT, 05009, USA.; Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA., Hay N; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA. smjeon@ajou.ac.kr.; Research & Development Section, Jesse Brown VA Medical Center, Chicago, IL, 60612, USA. smjeon@ajou.ac.kr.

Publikováno v: Nature communications [Nat Commun] 2022 Feb 16; Vol. 13 (1), pp. 899. Date of Electronic Publication: 2022 Feb 16.