Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Prashanth Kumar Kolluri"'
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Selective CDK4/6 inhibition of novel 1,2,3-triazole tethered acridinedione derivatives induces G1/S cell cycle transition arrest via Rb phosphorylation blockade in breast cancer models
Autor: N.J.P. Subhashini, Appaji Dokala, E. Praveenkumar, Nirmala Gurrapu, Prashanth Kumar Kolluri, Shivaraj
Publikováno v: Bioorganic chemistry. 116
CDK4 & CDK6 are essential regulators of initial cell cycle phases and are always considered an exciting choice for anti-cancer therapy. In the present study, we presented the structure-based rational design & synthesis of a new class of 1,2,3-triazol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af486ec09179b6f9556124179c29129
https://pubmed.ncbi.nlm.nih.gov/34670329
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4
Synthesis, anti-diabetic evaluation and molecular docking studies of 4-(1-aryl-1H-1, 2, 3-triazol-4-yl)-1,4-dihydropyridine derivatives as novel 11-β hydroxysteroid dehydrogenase-1 (11β-HSD1) inhibitors
Autor: Vishwanadham Yerragunta, Prashanth Kumar Kolluri, N.J.P. Subhashini, E. Praveenkumar, Nirmala Gurrapu, Bharathi Reddy Kunduru
Publikováno v: Bioorganic chemistry. 90
11-Beta-Hydroxysteroid dehydrogenase-1(11β-HSD1) inhibitors are one of the emerging classes of molecules to fight against diabetic complications. A novel series of 4-(1-substituted-1H-1,2,3-triazol-4-yl)-1,4-dihydropyridine derivatives were synthesi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f7b1b0523dc9781bd7a1cddd5b4c78
https://pubmed.ncbi.nlm.nih.gov/31276952
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5
Synthesis, biological evaluation and molecular docking studies of novel 1,2,3-triazole tethered chalcone hybrids as potential anticancer agents
Autor: Prashanth Kumar Kolluri, N.J.P. Subhashini, E. Praveen Kumar, Nirmala Gurrapu, Sree Kanth Sivan, Shravani Putta
Publikováno v: Journal of Molecular Structure. 1217:128356
As a part of our ongoing effort in a way to develop potential anti-cancer agents, a novel series of nine 1,2,3-triazole tethered chalcone hybrids were synthesized in good yields from suitable reaction procedures and were further characterized by vari
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51c4c1e8b1ba3c6fe892d195e72661af
https://doi.org/10.1016/j.molstruc.2020.128356
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6
Design, synthesis of novel (Z)-2-(3-(4-((3-benzyl-2,4-dioxothiazolidin-5-ylidene)methyl)-1-phenyl-1H-pyrazol-3-yl)phenoxy)-N-arylacetamide derivatives: Evaluation of cytotoxic activity and molecular docking studies
Autor: N.J.P. Subhashini, Shravani Putta, Prashanth Kumar Kolluri, Tamalapakula Vani, Vijjulatha Manga, Surya Sathyanarayana Singh, Nirmala Gurrapu
Publikováno v: Journal of Molecular Structure. 1202:127300
In an attempt to discover potential cytotoxic agents, a series of novel (Z)-2-(3-(4-((3-benzyl-2,4-dioxothiazolidin-5-ylidene)methyl)-1-phenyl-1H-pyrazol-3-yl) phenoxy)-N-arylacetamide derivatives 11a-n were synthesized in varied steps with acceptabl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fe5efe20a8487cc5ed02141dc968bd1
https://doi.org/10.1016/j.molstruc.2019.127300
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